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1.发明授权Water-soluble immunological adjuvants, in particular for vaccines, obtained from mycobacteria and related microorganisms and process for their extraction 失效从分枝杆菌和相关微生物获得的水溶性免疫佐剂，特别是用于疫苗的水溶性免疫佐剂及其提取方法
公开(公告)号：US3976544A
公开(公告)日：1976-08-24
申请号：US371512
申请日：1973-06-19
申请人： Arlette Adam , Frank Berger , Louis Chedid , Edgar Lederer , Jean-Francois Petit , Rita Ciorbaru
发明人： Arlette Adam , Frank Berger , Louis Chedid , Edgar Lederer , Jean-Francois Petit , Rita Ciorbaru
CPC分类号： C07K14/35 , A61K39/39 , A61K2039/55594 , A61K38/00 , Y10S435/803 , Y10S435/822 , Y10S435/866
摘要： The invention pertains to a water-soluble immunological adjuvant, especially for vaccines. It is obtained by enzymatic treatment of mycobacteria or Nocardia whole cells in aqueous medium and by a recovery from said aqueous medium.
摘要翻译： 本发明涉及水溶性免疫佐剂，特别是用于疫苗。 通过在水性介质中通过酶处理分枝杆菌或诺卡氏菌全细胞并通过从所述水性介质的回收获得。
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2.发明授权Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents 失效作为用于在宿主中刺激各种抗原和组合物的免疫应答的免疫佐剂的水溶性物质，特别是含有所述水溶性试剂的疫苗
公开(公告)号：US4235771A
公开(公告)日：1980-11-25
申请号：US906002
申请日：1978-05-15
申请人： Arlette Adam , Francoise Audibert , Louis Chedid , Jean Choay , Rita Ciorbaru , Fabrielle Ellouz , Dominique Juy , Pierre Lefrancier , Claude Merser , Jean-Francois Petit , Pierre Sinay , Edgar Lederer
发明人： Arlette Adam , Francoise Audibert , Louis Chedid , Jean Choay , Rita Ciorbaru , Fabrielle Ellouz , Dominique Juy , Pierre Lefrancier , Claude Merser , Jean-Francois Petit , Pierre Sinay , Edgar Lederer
CPC分类号： A61K39/39 , A61K35/74 , C07K9/005 , A61K2039/5555 , A61K2039/55583 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.
摘要翻译： 作为用于在宿主中刺激各种抗原的免疫应答的水溶性物质，其包含酰基 - 胞壁酰基酸基团，其中酰基是指乙酰基或糖基，以及与所述酰基 - 胞壁酸组连接的短肽链，第一 并且所述肽链的第二个氨基酸分别优选为丙氨酸和谷氨酸。
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3.发明授权Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents 失效作为免疫佐剂有效的水溶性物质，用于在宿主中刺激对各种抗原和组合物的免疫应答，特别是含有所述水溶性试剂的疫苗
公开(公告)号：US4186194A
公开(公告)日：1980-01-29
申请号：US516991
申请日：1974-10-22
申请人： Arlette Adam , Francoise Audibert , Louis Chedid , Jean Choay , Rita Ciorbaru , Fabrielle Ellouz , Dominique Juy , Pierre Lefrancier , Claude Merser , Jean-Francois Petit , Pierre Sinay , Edgar Lederer
发明人： Arlette Adam , Francoise Audibert , Louis Chedid , Jean Choay , Rita Ciorbaru , Fabrielle Ellouz , Dominique Juy , Pierre Lefrancier , Claude Merser , Jean-Francois Petit , Pierre Sinay , Edgar Lederer
IPC分类号： A61K35/74 , A61K38/00 , A61K39/00 , A61K39/39 , C07K9/00 , A61K39/12 , A61K37/00 , A61K39/02 , C07C103/52
CPC分类号： A61K39/39 , A61K35/74 , C07K9/005 , A61K2039/5555 , A61K2039/55583 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.
摘要翻译： 作为用于在宿主中刺激各种抗原的免疫应答的水溶性物质，其包含酰基 - 胞壁酰基酸基团，其中酰基是指乙酰基或乙酰基，以及与所述酰基 - 胞壁酸组连接的短肽链，第一 并且所述肽链的第二个氨基酸分别优选为丙氨酸和谷氨酸。
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4.发明授权Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents 失效作为用于在宿主中刺激各种抗原和组合物的免疫应答的免疫佐剂的水溶性物质，特别是含有所述水溶性试剂的疫苗
公开(公告)号：US4370265A
公开(公告)日：1983-01-25
申请号：US906003
申请日：1978-05-15
申请人： Arlette Adam , Francoise Audibert , Louis Chedid , Jean Choay , Rita Ciorbaru , Fabrielle Ellouz , Dominique Juy , Pierre Lefrancier , Claude Merser , Jean-Francois Petit , Pierre Sinay , Edgar Lederer
发明人： Arlette Adam , Francoise Audibert , Louis Chedid , Jean Choay , Rita Ciorbaru , Fabrielle Ellouz , Dominique Juy , Pierre Lefrancier , Claude Merser , Jean-Francois Petit , Pierre Sinay , Edgar Lederer
IPC分类号： A61K38/00 , A61K39/39 , C07H15/04 , C07K9/00 , C07C103/52
CPC分类号： C07H15/04 , A61K39/39 , C07K9/005 , A61K2039/5555 , A61K38/00 , Y10S530/806 , Y10S930/27
摘要： Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.
摘要翻译： 作为用于在宿主中刺激各种抗原的免疫应答的水溶性物质，其包含酰基 - 胞壁酰基酸基团，其中酰基是指乙酰基或乙酰基，以及与所述酰基 - 胞壁酸组连接的短肽链，第一 并且所述肽链的第二个氨基酸分别优选为丙氨酸和谷氨酸。
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公开(公告)号：US4152423A
公开(公告)日：1979-05-01
申请号：US806987
申请日：1977-06-16
CPC分类号： A61K39/39 , C07K14/35 , A61K2039/55511 , A61K2039/55566 , A61K2039/55594
摘要： The present invention relates to novel immunological agents effective as adjuvants for stimulating an immune response to various types of antigens. The adjuvants do not cause objectionable reactions and they are easily purified. The invention additionally relates to a process for producing the novel adjuvants.
摘要翻译： 本发明涉及作为刺激各种类型抗原的免疫应答的佐剂有效的新型免疫学试剂。 佐剂不引起令人反感的反应，并且它们容易纯化。 本发明还涉及一种生产新型佐剂的方法。
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公开(公告)号：US4036953A
公开(公告)日：1977-07-19
申请号：US307614
申请日：1972-11-17
IPC分类号： C12N1/20 , A61K35/74 , A61K39/02 , A61K39/04 , A61K39/39 , C07K14/35 , C12B1/00 , C12D13/02 , C12D13/10
CPC分类号： A61K35/74 , A61K39/39 , C07K14/35 , A61K2039/55511 , A61K2039/55566 , A61K2039/55594 , A61K38/00 , Y10S435/866 , Y10S435/869 , Y10S435/872
摘要： Water-soluble immunological adjuvants, extracted from mycobacteria and nocardia cells, useful for stimulating, in a host, the immune response to various kinds of antigens.
摘要翻译： 从分枝杆菌和诺卡氏菌细胞提取的水溶性免疫佐剂，可用于在宿主中刺激对各种抗原的免疫应答。
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