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公开(公告)号：US20090082591A1
公开(公告)日：2009-03-26
申请号：US12330130
申请日：2008-12-08
CPC分类号： C07C303/40 , C07B2200/07 , C07C45/41 , C07C67/343 , C07C227/18 , C07C259/06 , C07C303/38 , C07C313/06 , C07C69/65 , C07C311/19 , C07C311/17 , C07C229/20 , C07C47/14
摘要： Methods for preparing substituted phenylsulfonamide compounds of the following structure are provided: or a pharmaceutically acceptable salt thereof, wherein, R1-R7 are defined herein. Also provided are methods for preparing compounds of the following structure: wherein, R9, m, n, p, r, and s are defined herein.
摘要翻译： 提供了以下结构的取代苯基磺酰胺化合物的制备方法：或其药学上可接受的盐，其中R 1 -R 7在本文中定义。 还提供了制备以下结构的化合物的方法：其中，R9，m，n，p，r和s在本文中定义。
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公开(公告)号：US07476762B2
公开(公告)日：2009-01-13
申请号：US11788352
申请日：2007-04-19
IPC分类号： C07C303/00 , C07C229/00 , C07C241/00
CPC分类号： C07C303/40 , C07B2200/07 , C07C45/41 , C07C67/343 , C07C227/18 , C07C259/06 , C07C303/38 , C07C313/06 , C07C69/65 , C07C311/19 , C07C311/17 , C07C229/20 , C07C47/14
摘要： Methods for preparing substituted phenylsulfonamide compounds of the following structure are provided: or a pharmaceutically acceptable salt thereof, wherein, R1-R7 are defined herein. Also provided are methods for preparing compounds of the following structure: wherein, R9, m, n, p, r, and s are defined herein.
摘要翻译： 提供了以下结构的取代苯基磺酰胺化合物的制备方法：或其药学上可接受的盐，其中R 1 -R 7在本文中定义。 还提供了制备以下结构的化合物的方法：其中，R9，m，n，p，r和s在本文中定义。
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公开(公告)号：US20070249723A1
公开(公告)日：2007-10-25
申请号：US11788352
申请日：2007-04-19
IPC分类号： C07C309/30 , A61K31/18
CPC分类号： C07C303/40 , C07B2200/07 , C07C45/41 , C07C67/343 , C07C227/18 , C07C259/06 , C07C303/38 , C07C313/06 , C07C69/65 , C07C311/19 , C07C311/17 , C07C229/20 , C07C47/14
摘要： Methods for preparing substituted phenylsulfonamide compounds of the following structure are provided: or a pharmaceutically acceptable salt thereof, wherein, R1-R7 are defined herein.Also provided are methods for preparing compounds of the following structure: wherein, R9, m, n, p, r, and s are defined herein.
摘要翻译： 提供了以下结构的取代的苯基磺酰胺化合物的制备方法：或其药学上可接受的盐，其中R 1 -R 7在本文中定义。 还提供了制备以下结构的化合物的方法：其中R 9，m，n，p，r和s在本文中定义。
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公开(公告)号：US20080269213A1
公开(公告)日：2008-10-30
申请号：US11895222
申请日：2007-08-23
申请人： Matthew G. Bursavich , Sabrina Lombardi , Adam M. Gilbert , Leif Mark Laakso , Gulnaz Khafizova , David Brian How , Joshua James Sabatini , Phaik-Eng Sum , Jeremy Clemens
发明人： Matthew G. Bursavich , Sabrina Lombardi , Adam M. Gilbert , Leif Mark Laakso , Gulnaz Khafizova , David Brian How , Joshua James Sabatini , Phaik-Eng Sum , Jeremy Clemens
IPC分类号： A61K31/5377 , C07D401/12 , A61K31/4709 , A61K31/47 , A61P9/10 , C07D215/14 , C07D413/02
CPC分类号： C07D215/28 , C07D215/26 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/10 , C07D417/10
摘要： The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.
摘要翻译： 本发明涉及8-羟基喹啉化合物; 包含8-羟基喹啉化合物的组合物; 以及用于治疗或预防金属蛋白酶相关疾病如关节炎疾病，骨关节炎，恶性肿瘤，类风湿性关节炎，哮喘，慢性阻塞性肺病，动脉粥样硬化，年龄相关性黄斑变性，心肌梗塞，角膜溃疡， 眼表疾病，肝炎，主动脉瘤，腱炎，中枢神经系统疾病，伤口愈合异常，血管生成，再狭窄，肝硬化，多发性硬化，肾小球性肾炎，移植物抗宿主病，糖尿病，炎性肠病，休克，椎间盘退变 ，中风，骨质减少或牙周病，或包括向有需要的哺乳动物施用有效剂量的8-羟基喹啉化合物。
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公开(公告)号：US07276611B2
公开(公告)日：2007-10-02
申请号：US10844243
申请日：2004-05-12
申请人： Michael William Winkley , Anita Wai-Yin Chan , Ivo L. Jirkovsky , Kenneth Alfred Martin Kremer , Joseph Zeldis , Antonia Aristotelevna Nikitenko , Henry Lee Strong , Tarek Mansour , Gulnaz Khafizova , Aranapakam M. Venkatesan
发明人： Michael William Winkley , Anita Wai-Yin Chan , Ivo L. Jirkovsky , Kenneth Alfred Martin Kremer , Joseph Zeldis , Antonia Aristotelevna Nikitenko , Henry Lee Strong , Tarek Mansour , Gulnaz Khafizova , Aranapakam M. Venkatesan
IPC分类号： C07D231/54
CPC分类号： C07D498/04 , C07D487/04
摘要： There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are useful as intermediates in the preparation of β-lactamase inhibitors.
摘要翻译： 提供了一种制备具有结构式I的双环杂芳基羧醛的方法，其中X和Y在说明书中定义。双环杂芳基羧醛可用作制备β-内酰胺酶抑制剂的中间体。
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公开(公告)号：US07947712B2
公开(公告)日：2011-05-24
申请号：US11895222
申请日：2007-08-23
申请人： Matthew G. Bursavich , Sabrina Lombardi , Adam M. Gilbert , Leif Mark Laakso , Gulnaz Khafizova , David Brian How , Joshua James Sabatini , Phaik-Eng Sum , Jeremy Clemens
发明人： Matthew G. Bursavich , Sabrina Lombardi , Adam M. Gilbert , Leif Mark Laakso , Gulnaz Khafizova , David Brian How , Joshua James Sabatini , Phaik-Eng Sum , Jeremy Clemens
IPC分类号： C07D215/04 , A61K31/04
CPC分类号： C07D215/28 , C07D215/26 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/10 , C07D417/10
摘要： The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.
摘要翻译： 本发明涉及8-羟基喹啉化合物; 包含8-羟基喹啉化合物的组合物; 以及用于治疗或预防金属蛋白酶相关疾病如关节炎疾病，骨关节炎，恶性肿瘤，类风湿性关节炎，哮喘，慢性阻塞性肺病，动脉粥样硬化，年龄相关性黄斑变性，心肌梗塞，角膜溃疡， 眼表疾病，肝炎，主动脉瘤，腱炎，中枢神经系统疾病，伤口愈合异常，血管生成，再狭窄，肝硬化，多发性硬化，肾小球性肾炎，移植物抗宿主病，糖尿病，炎性肠病，休克，椎间盘退变 ，中风，骨质减少或牙周病，或包括向有需要的哺乳动物施用有效剂量的8-羟基喹啉化合物。
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公开(公告)号：US20100016609A1
公开(公告)日：2010-01-21
申请号：US12501709
申请日：2009-07-13
IPC分类号： C07D413/10
CPC分类号： C07D413/10
摘要： The present invention is directed to processes, compositions and methods associated with the preparation of azole derivatives of formula I:
摘要翻译： 本发明涉及与制备式I的唑衍生物有关的方法，组合物和方法：
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公开(公告)号：US20080009634A1
公开(公告)日：2008-01-10
申请号：US11820575
申请日：2007-06-18
申请人： Michael Winkley , Anita Chan , Ivo Jirkovsky , Kenneth Kremer , Joseph Zeldis , Antonia Nikitenko , Henry Strong , Tarek Mansour , Gulnaz Khafizova , Aranapakam Venkatesan
发明人： Michael Winkley , Anita Chan , Ivo Jirkovsky , Kenneth Kremer , Joseph Zeldis , Antonia Nikitenko , Henry Strong , Tarek Mansour , Gulnaz Khafizova , Aranapakam Venkatesan
IPC分类号： C07D277/60 , C07D487/04
CPC分类号： C07D498/04 , C07D487/04
摘要： There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are useful as intermediates in the preparation of β-lactamase inhibitors.
摘要翻译： 提供了一种制备具有结构式I的双环杂芳基羧醛的方法，其中X和Y在说明书中定义。双环杂芳基羧醛可用作制备β-内酰胺酶抑制剂的中间体。
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公开(公告)号：US20110212923A1
公开(公告)日：2011-09-01
申请号：US12866477
申请日：2009-02-06
申请人： Reinhardt Baudy , Eugene J. Trybulski , Ronald Magolda , Diane Schneider , Gulnaz Khafizova , Mahdi B. Fawzi , Cuijian Yang
发明人： Reinhardt Baudy , Eugene J. Trybulski , Ronald Magolda , Diane Schneider , Gulnaz Khafizova , Mahdi B. Fawzi , Cuijian Yang
IPC分类号： A61K31/675 , C07F9/653 , C07D263/57 , A61K31/423 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/00 , A61P17/00 , A61P3/10 , A61P19/02 , A61P11/06 , A61P3/00 , A61P3/06 , A61P9/10 , A61P9/12 , A61P25/28 , A61P25/22 , A61P17/06 , A61P17/04 , A61P15/00 , A61P13/00
CPC分类号： C07F9/65324
摘要： The present invention relates to phosphate derivatives of estrogen receptor beta agonists, compositions thereof, preparations thereof, and uses thereof. Formula (I).
摘要翻译： 本发明涉及雌激素受体β激动剂的磷酸酯衍生物，其组合物，制剂及其用途。 式（I）。
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10.发明授权公开(公告)号：US07714130B2
公开(公告)日：2010-05-11
申请号：US11154921
申请日：2005-06-16
IPC分类号： C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D403/12 , C07D235/08
摘要： Methods of making Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists, comprising reacting a compound having Formula I: with a compound having formula Lg—(CR13R14)k—D, are disclosed.
摘要翻译： 公开了制备促性腺激素释放激素（“GnRH”）（也称为激素释放激素）受体拮抗剂的方法，包括使式I化合物与式Lg-（CR13R14）k-D化合物反应。
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