公开(公告)号：US20130041147A1

公开(公告)日：2013-02-14

申请号：US13653615

申请日：2012-10-17

Applicant: BASF SE

Inventor： Thomas ZIERKE ,  Volker MAYWALD ,  Michael RACK ,  Sebastian Peer SMIDT ,  Michael KEIL ,  Bernd WOLF ,  Christopher KORADIN

IPC: C07D231/14 ,  C07D265/30 ,  C07D295/145

CPC classification number: C07D231/14 ,  C07C229/30 ,  C07D295/145

Abstract: The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3- oxobutteric esters of the formula (I) in which R1, R2 and R3 independently of one another are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl or NR2R3 is a 5- to 10-membered heterocyclic radical, to a process for preparing compounds of the formula (I) wherein an appropriate 3-aminoacrylic ester is reacted with difluoroacetyl fluoride and to the use of compounds of the formula (I) in the process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.

Abstract translation: 本发明涉及一种制备二氟甲基取代的吡唑-4-基羧酸及其酯的式（I）的2-（氨基亚甲基）-4,4-二氟-3-氧代异丁酯，其中R1，R2和 R 3彼此独立地是C 1 -C 6 - 烷基，C 1 -C 6 - 卤代烷基，C 2 -C 6 - 烯基，C 3 -C 10 - 环烷基或苄基或NR 2 R 3是5-至10-元杂环基， 式（I）的化合物，其中适当的3-氨基丙烯酸酯与二氟乙酰氟反应，以及在制备二氟甲基取代的吡唑-4-基羧酸及其酯的方法中使用式（I）的化合物。

公开(公告)号：US20160046572A1

公开(公告)日：2016-02-18

申请号：US14778771

申请日：2014-03-27

Applicant: BASF SE

Inventor： Timo FRASSETTO ,  Harald JOCKERS ,  Christopher KORADIN ,  Thomas ZIERKE ,  Karsten KOERBER

IPC: C07C381/10 ,  C07D401/04

CPC classification number: C07C381/10 ,  A01N37/28 ,  A01N43/56 ,  C07C2601/02 ,  C07D401/04 ,  C07D409/14

Abstract: The present invention relates to a process for preparing a compound of the formulae (Ia) or (Ib), or a mixture thereof, wherein R1 and R2 independently of one another are hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C10-cycloalkyl, C3-C10-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl or together represent an aliphatic chain, or the like; A− is HSO4− or 1/2 SO42−; the process comprising the reaction of a sulfide of formula SR1R2 with hydroxylamineO-sulfonic acid of formula; wherein the reaction is carried out in an aqueous medium in the presence of a base. The present invention also relates to a process for preparing a compound of the formula (IV), wherein R3 is halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C8-alkenyl, C2-C8-haloalkenyl, C1-C8-alkoxy, phenyl, or the like; R4 is hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl, phenyl, or the like; p is 0, 1, 2, 3 or 4; the process comprising: (i) providing the compound of the formulae (Ia) or (Ib), or a mixture thereof, (ii) reacting a compound of the formulae (Ia) or (Ib), or a mixture thereof, obtained in step (i) with a compound of the formula (V) in the presence of a base,

Abstract translation: 本发明涉及制备式（Ia）或（Ib）化合物或其混合物的方法，其中R 1和R 2彼此独立地是氢，C 1 -C 10 - 烷基，C 1 -C 10 - 卤代烷基， C 3 -C 10 - 环烷基，C 3 -C 10 - 卤代环烷基，C 2 -C 10 - 烯基，C 2 -C 10 - 卤代烯基或一起代表脂族链等; A-是HSO4-或1/2 SO42-; 该方法包括式SR 1 R 2的硫化物与式的羟胺O-磺酸的反应; 其中反应在碱的存在下在水性介质中进行。 本发明还涉及制备式（IV）化合物的方法，其中R 3是卤素，氰基，C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 3 -C 8 - 环烷基，C 3 -C 8 - 卤代环烷基， C 2 -C 8 - 烯基，C 2 -C 8 - 卤代烯基，C 1 -C 8 - 烷氧基，苯基等; R4是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基，苯基等; p是0，1，2，3或4; 该方法包括：（i）提供式（Ia）或（Ib）化合物或其混合物，（ii）使式（Ia）或（Ib）化合物或其混合物 步骤（i）与式（Ⅴ）化合物在碱的存在下反应，

公开(公告)号：US20210087207A1

公开(公告)日：2021-03-25

申请号：US16610186

申请日：2018-05-02

Applicant: BASF SE

Inventor： Harish SHINDE ,  Christopher KORADIN ,  Joachim DICKHAUT ,  Roland GOETZ ,  Eric George KLAUBER ,  Sukunath NARAYANAN ,  Dhanyakumar RAUT

IPC: C07D513/04

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.

公开(公告)号：US20200055872A1

公开(公告)日：2020-02-20

申请号：US16608290

申请日：2018-04-25

Applicant: BASF SE

Inventor： Harish SHINDE ,  Christopher KORADIN ,  Joachim DICKHAUT ,  Roland GOETZ ,  Michael RACK ,  Eric George KLAUBER ,  Sukunath NARAYANAN ,  Dhanyakumar RAUT

IPC: C07D513/04 ,  C07D417/04 ,  C07D277/32

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims or the description.

公开(公告)号：US20200231556A1

公开(公告)日：2020-07-23

申请号：US16634337

申请日：2018-07-20

Applicant: BASF SE

Inventor： Wassilios GRAMMENOS ,  Michael RACK ,  Violeta TERTERYAN-SEISER ,  Christopher KORADIN

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles, which are useful as fungicidal compounds or as intermediates for the synthesis of fungicidal oxaciazole compounds, using trifluoroacetyl halides.

公开(公告)号：US20160046645A1

公开(公告)日：2016-02-18

申请号：US14778788

申请日：2014-03-03

Applicant: BASF SE

Inventor： Burkhard ERNST ,  Manfred EHRESMANN ,  Christopher KORADIN ,  Andreas PLETSCH ,  Melanie BONNEKESSEL ,  Thomas KAEDING ,  Karin SCHEIN-ALBRECHT ,  Stefanie DEMMING ,  Franz WEBER ,  Wolfgang SIEGEL ,  Hartwig SCHROEDER ,  Stephan FREYER ,  Peter OEDMAN

IPC: C07D493/04 ,  C12P17/18 ,  A01N43/40

CPC classification number: C07D493/04 ,  A01N43/40 ,  C12P17/181

Abstract: The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula III and/or Formula IV and/or Formula V from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula III and/or Formula IV and/or Formula V, including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula IV and/or Formula V in order to produce pest control compositions, in particular insecticides, comprising such compounds.

Abstract translation: 本发明涉及产生拟南芥生产生物体的干生物质的方法，从这种干燥生物质获得拟南芥的方法，以及从得自二氯苯并呋喃衍生物的二氯代丙酸得到式III和/或式IV和/或式V化合物的方法 干生物量。 本发明进一步涉及干生物质本身，以及使用所述干生物质以获得用于生产式III和/或式IV和/或式V化合物的吡啶并苯的方法，包括使用所述干生物质获得吡啶并吡喃 或式III和/或式IV和/或式V的化合物，以便制备包含这些化合物的害虫控制组合物，特别是杀虫剂。

公开(公告)号：US20160229820A1

公开(公告)日：2016-08-11

申请号：US15029907

申请日：2014-10-06

Applicant: BASF SE

Inventor： Thomas ZIERKE ,  Jonas HILZENDEGEN ,  Christopher KORADIN ,  Karsten KOERBER ,  Roland GOETZ

IPC: C07D265/26 ,  C07D401/14 ,  C07D401/04 ,  C07C269/04 ,  C07C271/58

CPC classification number: C07D265/26 ,  C07C269/04 ,  C07C271/58 ,  C07D401/04 ,  C07D401/14

Abstract: The present invention relates to a process for preparing substituted isatoic acid anhydride compounds of the formula (I) in which R1 is Cl, Br, I, or CN; and R2 is CH3, Cl, Br; using anthranilic acid derivative compounds of formula (III) and/or carbamate compounds of formula (II) wherein R1 and R2 are as defined above; RAr is CH3, Cl, NO2 and n is 0, 1, 2, 3, 4 or 5; The present invention relates also to the compounds of formula (II) and to processes comprising further preceding and/or subsequent reaction steps, leading to anthranilamide pesticides or to precursors for them.

Abstract translation: 本发明涉及制备式（I）的取代的缩醛酸酐化合物的方法，其中R 1是Cl，Br，I或CN; 并且R 2是CH 3，Cl，Br; 使用式（III）的邻氨基苯甲酸衍生物化合物和/或式（II）的氨基甲酸酯化合物，其中R 1和R 2如上所定义; RAr为CH 3，Cl，NO 2，n为0,1,2,3,4或5; 本发明还涉及式（II）化合物和包括进一步的前述和/或后续反应步骤，导致邻氨基苯甲酰胺农药或其前体的方法。

公开(公告)号：US20160137624A1

公开(公告)日：2016-05-19

申请号：US14897953

申请日：2014-06-17

Applicant: BASF SE

Inventor： Thomas ZIERKE ,  Monika DOMRES ,  Christopher KORADIN ,  Karsten KOERBER

IPC: C07D401/04

CPC classification number: C07D401/04 ,  Y02P20/582

Abstract: The present invention relates to a process for preparing pyridylpyrazole compounds of the formula (I) starting from pyridylhydrazine of formula (II) The present invention relates also to processes comprising further preceding and/or subsequent reaction steps, leading to anthranilamide pesticides or to precursors for them.

Abstract translation: 本发明涉及从式（II）的吡啶基肼制备式（I）的吡啶基吡唑化合物的方法。本发明还涉及包含进一步的前述和/或后续反应步骤的方法，其导致邻氨基苯甲酰胺农药或前体 他们。

公开(公告)号：US20160096819A1

公开(公告)日：2016-04-07

申请号：US14890711

申请日：2014-05-16

Applicant: BASF SE

Inventor： Christopher KORADIN ,  Thomas ZIERKE ,  Ralf HOOCK ,  Karsten KOERBER

IPC: C07D401/04

CPC classification number: C07D401/04

Abstract: The present invention relates to a process for preparing N-substituted 1H-pyrazole-5-carboxylic acid compounds of the formula I-A and derivatives thereof, in particular the corresponding carbonylchloride compounds (acid chlorides). It also relates to the use of these acid chlorides for preparing anthranilamide derivatives that are useful pesticides. in which the variables are as defined in the claims and the specification comprising the steps of i) reacting a compound of the formula (II) with a base selected from combinations of a magnesium-organic compound having a carbon bound magnesium and a secondary amine and magnesium amides of secondary amines in the presence of a lithium halide, where the base is used in an amount sufficient to achieve at least 80% deprotonation of the compound of formula (II); and subjecting the product obtained in step (i) to a carboxylation by reacting it with carbon dioxide or a carbon dioxide equivalent, to obtain a magnesium salt of the compound of formula (I-A) and optionally aqueous workup to obtain the compound of the formula (I-A) as a free acid.

Abstract translation: 本发明涉及制备式I-A及其衍生物，特别是相应的碳酰氯化合物（酰氯）的N-取代的1H-吡唑-5-羧酸化合物的方法。 它还涉及这些酰氯用于制备有用农药的邻氨基苯甲酰胺衍生物的用途。 其中变量如权利要求和说明书中所定义，其包括以下步骤：i）使式（II）的化合物与选自具有碳结合的镁和仲胺的镁 - 有机化合物的组合的碱反应，以及 在卤化锂存在下，仲胺的胺化合物，其中碱的用量足以达到式（II）化合物的至少80％去质子化; 和通过使其与二氧化碳或二氧化碳当量反应使步骤（ⅰ）中获得的产物进行羧化，得到式（IA）化合物的镁盐，并任选地进行水处理，得到式 IA）作为游离酸。

公开(公告)号：US20160046644A1

公开(公告)日：2016-02-18

申请号：US14760302

申请日：2014-01-15

Applicant: BASF SE

Inventor： Melanie BONNEKESSEL ,  Wolfgang REICHERT ,  Ralf HOOCK ,  Thomas KAEDING ,  Christopher KORADIN ,  Andreas PLETSCH ,  Manfred EHRESMANN ,  Hartwig SCHROEDER

IPC: C07D493/04

CPC classification number: C07D493/04 ,  A01N43/90 ,  A01N53/00

Abstract: The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).

Abstract translation: 本发明涉及一种制备式（I）的吡啶并苯化合物的方法，该方法包括以下步骤：i）使式Pyripyropene A的吡啶并吡喃化合物进行碱水解，得到1,7,11-三乙酰基吡啶 ，ii）使步骤i）中获得的1,1,11-三乙酰基吡啶并甲与环丙烷碳酰氯反应，得到含有式（I）的吡啶并吡喃化合物的粗产物; iii）使步骤ii）的粗产物进行结晶，得到式（I）的结晶吡啶并吡喃化合物和母液; 和iv）将含有其部分的母液或含吡啶并吡喃化合物再循环到步骤i）的碱水解。