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公开(公告)号:US20230042456A1
公开(公告)日:2023-02-09
申请号:US17786864
申请日:2020-12-16
Applicant: BASF SE
Inventor: Hartwig SCHROEDER , Anne-Catrin HAILER , Birgit HOFF , Oskar ZELDER , Peter OEDMAN , Georg Benjamin WANDREY , Christian DIETZSCH , Mukesh KUMAR , Dominik SATORY , Matthew David BLANKSCHIEN , Jens Klaus PLASSMEIER
Abstract: Increasing space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility in the production of fine chemicals The inventors of the current invention have found a surprising positive effect of increased cAMP levels and/or manipulating the PTS system on the space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility of fine chemical production of a host organism. This was achieved by de-regulating adenylate cyclase cyaa by deleting the C-terminal regulatory region leading to increased cAMP levels or deleting the Crr protein activity (carbohydrate repression resistance) which regulates the carbohydrate utilization system. Both lead to increased 2-fucosyllactoe and 6-sialyllactose production (human milk oligosaccharides) and increase carbohydrate usage.
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公开(公告)号:US20160046645A1
公开(公告)日:2016-02-18
申请号:US14778788
申请日:2014-03-03
Applicant: BASF SE
Inventor: Burkhard ERNST , Manfred EHRESMANN , Christopher KORADIN , Andreas PLETSCH , Melanie BONNEKESSEL , Thomas KAEDING , Karin SCHEIN-ALBRECHT , Stefanie DEMMING , Franz WEBER , Wolfgang SIEGEL , Hartwig SCHROEDER , Stephan FREYER , Peter OEDMAN
IPC: C07D493/04 , C12P17/18 , A01N43/40
CPC classification number: C07D493/04 , A01N43/40 , C12P17/181
Abstract: The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula III and/or Formula IV and/or Formula V from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula III and/or Formula IV and/or Formula V, including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula IV and/or Formula V in order to produce pest control compositions, in particular insecticides, comprising such compounds.
Abstract translation: 本发明涉及产生拟南芥生产生物体的干生物质的方法,从这种干燥生物质获得拟南芥的方法,以及从得自二氯苯并呋喃衍生物的二氯代丙酸得到式III和/或式IV和/或式V化合物的方法 干生物量。 本发明进一步涉及干生物质本身,以及使用所述干生物质以获得用于生产式III和/或式IV和/或式V化合物的吡啶并苯的方法,包括使用所述干生物质获得吡啶并吡喃 或式III和/或式IV和/或式V的化合物,以便制备包含这些化合物的害虫控制组合物,特别是杀虫剂。
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公开(公告)号:US20170283840A1
公开(公告)日:2017-10-05
申请号:US15514321
申请日:2015-09-30
Applicant: BASF SE
Inventor: Michael BRAUN , Juergen DAEUWEL , Hans-Juergen LANG , Peter OEDMAN , Kai-Uwe BALDENIUS , Matthias KLEINER , Michael KIEFER , Stephan FREYER , Michael BUDDE
CPC classification number: C12P13/02 , C07C233/09 , C08F20/56 , C08L33/26 , C08L2201/54 , C09K8/588 , C12Y402/01084 , D21H17/375
Abstract: The present invention relates to methods for preparing an aqueous acrylamide solution having a low acrylic acid concentration. In addition, the present invention relates to methods for reducing the acrylic acid concentration of an aqueous acrylamide solution. The methods involve a bioconversion of acrylonitrile to acrylamide in the presence of a biocatalyst, wherein during the bioconversion the content of acrylonitrile is maintained at 0.3 w/w % or more referred to the total weight of the composition in the reactor. Also provided is an aqueous acrylamide solution which is obtained by the methods of the present invention. Furthermore, the present invention is related to an acrylamide homopolymer or copolymer obtained by polymerizing the acrylamide of the aqueous solution.
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公开(公告)号:US20170247726A1
公开(公告)日:2017-08-31
申请号:US15513670
申请日:2015-09-30
Applicant: BASF SE
Inventor: Michael BUDDE , Michael BRAUN , Juergen DAEUWEL , Peter OEDMAN , Kai-Uwe BALDENIUS , Matthias KLEINER , Stephan FREYER
CPC classification number: C12P13/02 , C12N9/78 , C12N9/80 , C12Y305/01004 , C12Y305/05001
Abstract: The present invention relates to means and methods for producing an amide compound from a nitrile compound with less acrylic acid as by-product using a Nitrile hydratase (NHase) and Amidase producing microorganism as biocatalyst. Also provided is an aqueous amide compound obtained by the methods of the invention as well as a composition comprising acrylamide or polyacrylamide as well as a dried microorganism exhibiting a NHase/Amidase activity ratio of at least 400 when being brought into contact with a nitrile compound to convert said nitrile compound into an amide compound.
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公开(公告)号:US20220403426A1
公开(公告)日:2022-12-22
申请号:US17774463
申请日:2020-11-04
Applicant: BASF SE
Inventor: Diego GHISLIERI , Peter OEDMAN , Tobias Joachim ZIMMERMANN
Abstract: The present invention relates to a method of storing a biocatalyst, which biocatalyst is capable of converting acrylonitrile to acrylamide, comprising the steps: (a) providing an aqueous suspension comprising the biocatalyst, which is capable of converting acrylonitrile to acrylamide, which aqueous suspension is an aqueous fermentation broth; (b) sequentially in either order or simultaneously (b) concentrating the aqueous suspension comprising the biocatalyst to a concentration of at least 3% (w/w); and (b2) reducing the temperature of the aqueous suspension comprising the biocatalyst to a temperature of below 8° C., thereby forming a concentrated aqueous suspension; and (c) maintaining the concentrated aqueous suspension of step (b) at a temperature of below 8° C. The invention also relates to a biocatalyst composition obtainable by this method and also the use of the biocatalyst composition in a process of preparing (meth-) acrylamide aqueous solution from (meth-) acrylonitrile. The invention further relates to a method for producing an aqueous (meth-) acrylamide solution comprising the aforementioned storage method and also to a method for producing polyacrylamide comprising the aforementioned storage method.
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公开(公告)号:US20210388014A1
公开(公告)日:2021-12-16
申请号:US17286474
申请日:2019-10-17
Applicant: BASF SE
Inventor: Michael PUHL , Sebastian WLOCH , Peter OEDMAN , Anne-Catrin LETZEL , Hartwing SCHROEDER , Jacek MALISZ , Daniel SEIBERT-LUDWIG , Emiel Jan KAPPERT , Chung Huan WONG , Michael BARROS GROSS , Martin VIERTELHAUS
Abstract: The present invention relates to a method for obtaining crystalline 2′-fucosyllactose from a 2′-FL raw material, which contains 2′-FL as a main constituent and at least 0.5% by weight, frequently at least 1% by weight, in particular at least 2% by weight, more particularly at least 5% by weight, and especially at least 8% by weight,based on the total amount of mono-and oligosaccharides in the raw material, of one or more mono- or oligosaccharides different from 2′-FL, where the method comprises a)providing a solution of the 2′-FL raw material in water, which does not contain more than 10% by weight, preferably not more than 7% by weight, more preferably not more than 5% by weight of organic solvents, based on the total amount of water; b) effecting the crystallization of 2′-FL from the solution provided in step a) by inducing conditions of a controlled super saturation in the solution; and c) separating crystalline 2′-FL from the mother liquor, and where during controlled supersaturation in step b) not more than 10% by weight, preferably not more than 7% by weight, more preferably not more than 5% by weight of organic solvents are present, based on the total amount of water present during step b).
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公开(公告)号:US20170260519A1
公开(公告)日:2017-09-14
申请号:US15512792
申请日:2015-09-30
Applicant: BASF SE
Inventor: Kerstin HAGE , Carsten SCHWALB , Petra SPROETE , Peter OEDMAN , Kai-Uwe BALDENIUS , Burkhard ERNST , Gunter STEIGELMANN , Stephan FREYER , Claus BOLLSCHWEILER , Michael Guenter BRAUN , Juergen DAEUWEL
CPC classification number: C12N9/88 , C12N1/20 , C12N1/38 , C12Y402/01084
Abstract: The present invention relates to methods for cultivating a nitrile hydratase producing microorganism, compositions for cultivating a nitrile hydratase producing microorganism, and use of compositions comprising a saccharide and an organic acid for cultivating a nitrile hydratase producing microorganism. The composition provided in and to be employed in context with the present invention is particularly suitable for inducing both, growth and nitrile hydratase production of corresponding microorganisms.
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