利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

243 条记录 (耗时 0.073 秒)

    N-substituted carbamic acid ester production method, isocyanate production method using such N-substituted carbamic acid ester, and composition for transfer and storage of N-substituted carbamic acid ester comprising N-substituted carbamic acid ester and aromatic hydroxy compound
    5.
    发明授权
    N-substituted carbamic acid ester production method, isocyanate production method using such N-substituted carbamic acid ester, and composition for transfer and storage of N-substituted carbamic acid ester comprising N-substituted carbamic acid ester and aromatic hydroxy compound 有权
    N-取代氨基甲酸酯的制造方法，使用这种N-取代氨基甲酸酯的异氰酸酯的制造方法以及N-取代氨基甲酸酯和芳香族羟基化合物的N-取代氨基甲酸酯的转移和储存组合物

    公开(公告)号：US09145357B2

    公开(公告)日：2015-09-29

    申请号：US14151178

    申请日：2014-01-09

    申请人： Asahi Kasei Chemicals Corporation

    发明人： Masaaki Shinohata ,  Nobuhisa Miyake

    IPC分类号： C07C263/00 ,  C07C263/04 ,  C07C275/40 ,  C07C269/00 ,  C07C269/04 ,  C07C271/54 ,  C07C271/56 ,  C07C271/58

    CPC分类号： C07C275/40 ,  C07C263/04 ,  C07C269/00 ,  C07C269/04 ,  C07C271/54 ,  C07C271/56 ,  C07C271/58 ,  C07C2601/14 ,  C07C265/14 ,  C07C271/52

    摘要： The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

    摘要翻译： 本发明是从有机胺，碳酸衍生物和含有一种以上羟基化合物的羟基组合物生产由有机胺衍生的N-取代氨基甲酸酯的方法，其中有机胺，碳酸 衍生物和羟基组合物使用设置有冷凝器，含有羟基组合物的气体，具有衍生自碳酸衍生物的羰基的化合物和在反应中作为副产物形成的氨的氨基甲酸酯制备反应容器进行反应 被引入聚氨酯生产反应容器中的冷凝器中，羟基组合物和衍生自碳酸衍生物的具有羰基的化合物被缩合，其中在缩合羟基组合物中包含的羟基化合物的化学计量比与 具有衍生自碳酸衍生物的羰基的缩合化合物 为1以上，由碳酸衍生物衍生的具有羰基的化合物中所含的羰基数（-C（= O） - ））与作为气体回收的氨中氨分子数的比例 冷凝器为1或更小。

    COMPOSITIONS AND METHODS FOR THE TREATMENT OF LOCAL PAIN
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR THE TREATMENT OF LOCAL PAIN 有权
    用于治疗局部疼痛的组合物和方法

    公开(公告)号：US20150119423A1

    公开(公告)日：2015-04-30

    申请号：US14399520

    申请日：2013-05-18

    申请人： Mahesh Kandula

    发明人： Mahesh Kandula

    IPC分类号： A61K31/165 ,  A61K45/06 ,  C07C233/22

    CPC分类号： A61K31/165 ,  A61K31/12 ,  A61K31/167 ,  A61K31/198 ,  A61K31/202 ,  A61K31/27 ,  A61K31/385 ,  A61K31/445 ,  A61K45/06 ,  C07C233/22 ,  C07C271/58 ,  A61K2300/00

    摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of local pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of moderate to severe pain, neuropathic pain, post herpetic neuralgia and rheumatic pains.

    摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物和用于治疗局部疼痛的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 此类组合物可用于治疗中度至重度疼痛，神经性疼痛，疱疹后神经痛和风湿性疼痛。

    Processes for producing aryl carbamates, isocynates and polyureas using diaryl carbonate
    7.
    发明授权
    Processes for producing aryl carbamates, isocynates and polyureas using diaryl carbonate 有权
    使用碳酸二芳基酯生产芳基氨基甲酸酯，异氰酸酯和聚脲的方法

    公开(公告)号：US09012676B2

    公开(公告)日：2015-04-21

    申请号：US13239664

    申请日：2011-09-22

    申请人： Shenghong A. Dai ,  Hsueh-Yung Chen ,  Chao-Hsing Lin ,  Chun-Ying Huang ,  Wen-Chen Pan

    发明人： Shenghong A. Dai ,  Hsueh-Yung Chen ,  Chao-Hsing Lin ,  Chun-Ying Huang ,  Wen-Chen Pan

    IPC分类号： C07C261/00 ,  C07C269/00 ,  C07C271/00 ,  C07C263/04 ,  C07C269/04 ,  C08G18/76 ,  C08G71/02

    CPC分类号： C07C263/04 ,  C07C269/04 ,  C08G18/7671 ,  C08G71/02 ,  C07C271/58 ,  C07C265/14

    摘要： A preparation of aryl carbamates can be achieved readily by carbonylation of an aromatic polyamine compound with diphenyl carbonate (DPC) using a combination of an organic acid and a tertiary amine as a catalyst. Aryl carbamate can be converted into 4,4′-diphenylmethane diisocyanate (MDI) by heating it at about 200 to about 230° C. in a non-polar solvent containing inhibitor such as benzoyl chloride. In another application, trans-ureation of biscarbamates with an amine or mixed amines is found to be extremely facile in a polar solvent such as dimethyl sulfoxide (DMSO) and tetramethylene sulfone (TMS) in absence of any catalyst to make polyurea polymers of high molecular weights. Thus, efficient green-chemistry processes based on biscarbamates in making isocyanate products as well as urea prepolymers, urea elastomers and urea plastics have been developed in all in excellent yields without using reactive phosgene or 4,4′-diphenylmethane diisocyanate separately in the trans-ureation polymerizations.

    摘要翻译： 通过使用有机酸和叔胺的组合作为催化剂使芳族多胺化合物与碳酸二苯酯（DPC）羰基化，可以容易地实现氨基甲酸芳基酯的制备。 通过在含有非极性溶剂的抑制剂如苯甲酰氯中将其加热至约200至约230℃，将氨基甲酸芳酯转化为4,4'-二苯基甲烷二异氰酸酯（MDI）。 在另一个应用中，发现在不存在任何催化剂的情况下，在极性溶剂如二甲基亚砜（DMSO）和四亚甲基砜（TMS）中，使用胺或混合胺转化双氨基甲酸酯非常容易地制备高分子量的聚脲聚合物 重量 因此，在制备异氰酸酯产物以及尿素预聚物，尿素弹性体和尿素塑料中基于双氨基甲酸酯的高效绿色化学方法已经以优异的产率开发，而不用在反式碳酸酯中分别使用反应性光气或4,4'-二苯基甲烷二异氰酸酯， 脲化聚合。