公开(公告)号：US20230042456A1

公开(公告)日：2023-02-09

申请号：US17786864

申请日：2020-12-16

Applicant: BASF SE

Inventor： Hartwig SCHROEDER ,  Anne-Catrin HAILER ,  Birgit HOFF ,  Oskar ZELDER ,  Peter OEDMAN ,  Georg Benjamin WANDREY ,  Christian DIETZSCH ,  Mukesh KUMAR ,  Dominik SATORY ,  Matthew David BLANKSCHIEN ,  Jens Klaus PLASSMEIER

IPC: C12P19/04 ,  C12N9/88

Abstract: Increasing space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility in the production of fine chemicals The inventors of the current invention have found a surprising positive effect of increased cAMP levels and/or manipulating the PTS system on the space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility of fine chemical production of a host organism. This was achieved by de-regulating adenylate cyclase cyaa by deleting the C-terminal regulatory region leading to increased cAMP levels or deleting the Crr protein activity (carbohydrate repression resistance) which regulates the carbohydrate utilization system. Both lead to increased 2-fucosyllactoe and 6-sialyllactose production (human milk oligosaccharides) and increase carbohydrate usage.

公开(公告)号：US20160046645A1

公开(公告)日：2016-02-18

申请号：US14778788

申请日：2014-03-03

Applicant: BASF SE

Inventor： Burkhard ERNST ,  Manfred EHRESMANN ,  Christopher KORADIN ,  Andreas PLETSCH ,  Melanie BONNEKESSEL ,  Thomas KAEDING ,  Karin SCHEIN-ALBRECHT ,  Stefanie DEMMING ,  Franz WEBER ,  Wolfgang SIEGEL ,  Hartwig SCHROEDER ,  Stephan FREYER ,  Peter OEDMAN

IPC: C07D493/04 ,  C12P17/18 ,  A01N43/40

CPC classification number: C07D493/04 ,  A01N43/40 ,  C12P17/181

Abstract: The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula III and/or Formula IV and/or Formula V from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula III and/or Formula IV and/or Formula V, including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula IV and/or Formula V in order to produce pest control compositions, in particular insecticides, comprising such compounds.

Abstract translation: 本发明涉及产生拟南芥生产生物体的干生物质的方法，从这种干燥生物质获得拟南芥的方法，以及从得自二氯苯并呋喃衍生物的二氯代丙酸得到式III和/或式IV和/或式V化合物的方法 干生物量。 本发明进一步涉及干生物质本身，以及使用所述干生物质以获得用于生产式III和/或式IV和/或式V化合物的吡啶并苯的方法，包括使用所述干生物质获得吡啶并吡喃 或式III和/或式IV和/或式V的化合物，以便制备包含这些化合物的害虫控制组合物，特别是杀虫剂。

公开(公告)号：US20180148748A1

公开(公告)日：2018-05-31

申请号：US15579291

申请日：2016-06-02

Applicant: BASF SE

Inventor： Qingzhao WANG ,  Shakir Siraj RATANI ,  Zheyuan GUO ,  Hartwig SCHROEDER ,  Holger HARTMANN ,  Markus POMPEJUS

IPC: C12P13/06 ,  C12N15/70 ,  C07K14/245 ,  C12N1/20

CPC classification number: C12P13/06 ,  C07K14/245 ,  C12N1/20 ,  C12N15/70

Abstract: Recombinant microorganism for improved production of fine chemicals The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

公开(公告)号：US20160046644A1

公开(公告)日：2016-02-18

申请号：US14760302

申请日：2014-01-15

Applicant: BASF SE

Inventor： Melanie BONNEKESSEL ,  Wolfgang REICHERT ,  Ralf HOOCK ,  Thomas KAEDING ,  Christopher KORADIN ,  Andreas PLETSCH ,  Manfred EHRESMANN ,  Hartwig SCHROEDER

IPC: C07D493/04

CPC classification number: C07D493/04 ,  A01N43/90 ,  A01N53/00

Abstract: The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).

Abstract translation: 本发明涉及一种制备式（I）的吡啶并苯化合物的方法，该方法包括以下步骤：i）使式Pyripyropene A的吡啶并吡喃化合物进行碱水解，得到1,7,11-三乙酰基吡啶 ，ii）使步骤i）中获得的1,1,11-三乙酰基吡啶并甲与环丙烷碳酰氯反应，得到含有式（I）的吡啶并吡喃化合物的粗产物; iii）使步骤ii）的粗产物进行结晶，得到式（I）的结晶吡啶并吡喃化合物和母液; 和iv）将含有其部分的母液或含吡啶并吡喃化合物再循环到步骤i）的碱水解。