公开(公告)号：US20200331829A1

公开(公告)日：2020-10-22

申请号：US16756961

申请日：2018-10-31

Applicant: BASF SE

Inventor： Daniel Saelinger ,  Philip Muelheims ,  Helmut Zech ,  Roland Goetz

IPC: C07C41/16

Abstract: The present invention relates to a process for preparing 4-chlorobenzyl propargylether comprising a step (a) of reacting 4-chlorobenzyl chloride with propargyl alcohol in the presence of a base and a phase transfer catalyst, wherein the reaction mixture comprises at least two phases, wherein one phase is an organic phase and one phase is an aqueous phase.

公开(公告)号：US11358922B2

公开(公告)日：2022-06-14

申请号：US16756961

申请日：2018-10-31

Applicant: BASF SE

Inventor： Daniel Saelinger ,  Philip Muelheims ,  Helmut Zech ,  Roland Goetz

IPC: C07C41/16 ,  C07C43/176 ,  C07C41/01 ,  C07C43/166

Abstract: The present invention relates to a process for preparing 4-chlorobenzyl propargylether comprising a step (a) of reacting 4-chlorobenzyl chloride with propargyl alcohol in the presence of a base and a phase transfer catalyst, wherein the reaction mixture comprises at least two phases, wherein one phase is an organic phase and one phase is an aqueous phase.

公开(公告)号：US09278977B2

公开(公告)日：2016-03-08

申请号：US14220561

申请日：2014-03-20

Applicant: BASF SE

Inventor： Frederik Menges ,  Joachim Gebhardt ,  Michael Rack ,  Michael Keil ,  Rodney F. Klima ,  David Cortes ,  Robert Leicht ,  Helmut Zech ,  Jochen Schroeder

IPC: C07D401/04 ,  C07D213/00 ,  C07D491/048 ,  C07D213/81 ,  C07D405/04 ,  C07D213/803

CPC classification number: C07D491/048 ,  C07D213/803 ,  C07D213/81 ,  C07D401/04 ,  C07D405/04

Abstract: A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Abstract translation: 制备其中Z为氢或卤素的5-氯甲基-2,3-吡啶二羧酸酐（I）的方法; Z1是氢，卤素，氰基或硝基; 包括以下步骤：（i）使式（II）化合物（其中符号具有式（I）中给出的含义）与氯化剂反应，任选在自由基引发剂存在下，在选自卤代烃， 和（ii）从选自氯苯，1,2-二氯苯，1,3-二氯苯，1,4-二氯苯，二氯乙烷，三氯甲烷，二氯甲烷，甲苯，二甲苯中的溶剂中，使步骤（i）中形成的化合物（I） ，乙酸乙酯，甲基叔丁基醚及其混合物。 化合物（I）是合成除草咪唑啉酮的有用中间体。