公开(公告)号：US09278977B2

公开(公告)日：2016-03-08

申请号：US14220561

申请日：2014-03-20

Applicant: BASF SE

Inventor： Frederik Menges ,  Joachim Gebhardt ,  Michael Rack ,  Michael Keil ,  Rodney F. Klima ,  David Cortes ,  Robert Leicht ,  Helmut Zech ,  Jochen Schroeder

IPC: C07D401/04 ,  C07D213/00 ,  C07D491/048 ,  C07D213/81 ,  C07D405/04 ,  C07D213/803

CPC classification number: C07D491/048 ,  C07D213/803 ,  C07D213/81 ,  C07D401/04 ,  C07D405/04

Abstract: A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Abstract translation: 制备其中Z为氢或卤素的5-氯甲基-2,3-吡啶二羧酸酐（I）的方法; Z1是氢，卤素，氰基或硝基; 包括以下步骤：（i）使式（II）化合物（其中符号具有式（I）中给出的含义）与氯化剂反应，任选在自由基引发剂存在下，在选自卤代烃， 和（ii）从选自氯苯，1,2-二氯苯，1,3-二氯苯，1,4-二氯苯，二氯乙烷，三氯甲烷，二氯甲烷，甲苯，二甲苯中的溶剂中，使步骤（i）中形成的化合物（I） ，乙酸乙酯，甲基叔丁基醚及其混合物。 化合物（I）是合成除草咪唑啉酮的有用中间体。

公开(公告)号：US10273216B2

公开(公告)日：2019-04-30

申请号：US15751349

申请日：2016-08-02

Applicant: BASF SE

Inventor： Eric George Klauber ,  Timo Frassetto ,  Reinhold Niemes ,  Ralf Bauer ,  Jochen Schroeder

IPC: C07D231/22 ,  C07D231/04 ,  C07D231/24

Abstract: The present invention relates to a process for preparing crystalline methyl N-[2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl]-N-methoxycarbamate (I), comprising a) reacting a compound of formula II with an alkylating agent in the presence of a base in the presence of a polar solvent selected from alcohols and ketons; b) the addition of water.