公开(公告)号：US20230081929A1

公开(公告)日：2023-03-16

申请号：US17799016

申请日：2021-02-12

Applicant: BASF SE

Inventor： Katie Kline ,  Amanda Rae Logue ,  Asfia Qureshi ,  Cindy Hoang ,  Jesper Nielsen ,  Mark Miller ,  Tong Li

IPC: C12N15/52 ,  C12N9/24

Abstract: A mannanase at least 75% identical to SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4, a polynucleotide encoding the mannanase, an expression construct comprising the polynucleotide, and a host cell comprising the polynucleotide or the expression construct.

公开(公告)号：US20230095147A1

公开(公告)日：2023-03-30

申请号：US17798973

申请日：2021-02-12

Applicant: BASF SE

Inventor： Jesper Nielsen ,  Katie Kline ,  Amanda Rae Logue ,  Cindy Hoang ,  Mark Miller ,  Asfia Qureshi ,  Tong Li ,  Priya Anand

IPC: C11D3/386 ,  C12N9/24 ,  C12N15/75 ,  C11D3/22 ,  C11D11/00

Abstract: A mannanase at least 75% identical to SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4, a poly-nucleotide encoding mannanase, an expression construct comprising the polynucleotide, and a host cell comprising the polynucleotide or the expression construct.

公开(公告)号：US20220186200A1

公开(公告)日：2022-06-16

申请号：US17438088

申请日：2020-03-10

Applicant: BASF SE

Inventor： Hugo Urbina ,  Kristine W. Chang ,  Tong Li ,  Xuqiu Tan ,  Jared Dennis ,  Jochen Kutscher ,  Adrienne Huston Davenport

IPC: C12N9/26

Abstract: Variant polypeptides having G4-amylase activity and methods of making and using the enzymes in baking, detergents, personal care products, in the processing of textiles, in pulp and paper processing, in the production of ethanol, lignocellulosic ethanol, or syrups; or as viscosity breakers in oilfield and mining industries.

公开(公告)号：US20230274789A1

公开(公告)日：2023-08-31

申请号：US18141199

申请日：2023-04-28

Applicant: BASF SE

Inventor： Tong Li ,  Brian Standen ,  Dejan Caglic

IPC: G16B15/20 ,  G16B40/20 ,  G16B15/30 ,  G06N10/60

CPC classification number: G16B15/20 ,  G16B40/20 ,  G16B15/30 ,  G06N10/60

Abstract: Exemplary embodiments relate to a protein engineering pipeline configured to optimize or improve proteins for specified functions. The problem space of such a task can grow quickly based on the sequence of the protein being optimized and the functions for which the protein is being designed. The solutions described herein allow the problem space to be efficiently searched by applying a combination of a protein design pipeline and an evaluation procedure performed on a quantum computer. As a result, single or multiple amino acid substitutions at a site of interest may be predicted in order to generate optimized protein variants.

公开(公告)号：US20230042150A1

公开(公告)日：2023-02-09

申请号：US17772976

申请日：2021-07-06

Applicant: BASF SE

Inventor： Tong Li ,  Brian Standen ,  Dejan Caglic

IPC: G16B15/20 ,  G16B15/30 ,  G16B40/20 ,  G06N10/60

Abstract: Exemplary embodiments relate to a protein engineering pipeline configured to optimize or improve proteins for specified functions. The problem space of such a task can grow quickly based on the sequence of the protein being optimized and the functions for which the protein is being designed. The solutions described herein allow the problem space to be efficiently searched by applying a combination of a protein design pipeline and an evaluation procedure performed on a quantum computer. As a result, single or multiple amino acid substitutions at a site of interest may be predicted in order to generate optimized protein variants.

公开(公告)号：US20220170001A1

公开(公告)日：2022-06-02

申请号：US17442675

申请日：2020-03-24

Applicant: BASF SE

Inventor： Asfia Qureshi ,  Zachary David Miles ,  Xuqiu Tan ,  Tong Li ,  Jared Dennis ,  Stefan Jenewein ,  Priya Anand ,  Jesper Nielsen

IPC: C12N9/26 ,  C12N1/20 ,  C12N15/75 ,  A21D8/04

Abstract: Genetically engineered enzymes having amylase enzyme activity, compositions comprising the enzymes, and methods of making and using the enzymes. Fragments of parent amylase enzymes activity and methods of using the fragments for making genetically engineered enzymes having amylase activity. The genetically engineered amylase enzymes are useful in many different applications such as laundry detergents, dish washing detergents, and cleaning products for homes, industry, vehicle care, baking, animal feed, pulp and paper processing, starch processing, brewing, and ethanol production.

公开(公告)号：US20230212544A1

公开(公告)日：2023-07-06

申请号：US18086034

申请日：2022-12-21

Applicant: BASF SE

Inventor： Hugo Urbina ,  Tong Li ,  Jared Dennis ,  Xuqiu Tan ,  Adrienne Huston Davenport ,  Jochen Kutscher ,  Kristine W. Chang

IPC: C12N9/26

CPC classification number: C12N9/2425 ,  C12Y302/01002

Abstract: Variant polypeptides having beta-amylase activity and methods of making and using the enzymes in baking, detergents, personal care products, in the processing of textiles, in pulp and paper processing, in the production of ethanol, lignocellulosic ethanol, or syrups; as viscosity breakers in oilfield and mining industries.

公开(公告)号：US11657894B2

公开(公告)日：2023-05-23

申请号：US17772976

申请日：2021-07-06

Applicant: BASF SE

Inventor： Tong Li ,  Brian Standen ,  Dejan Caglic

IPC: G16B15/20 ,  G06N10/60 ,  G16B40/20 ,  G16B15/30

CPC classification number: G16B15/20 ,  G06N10/60 ,  G16B15/30 ,  G16B40/20

Abstract: Exemplary embodiments relate to a protein engineering pipeline configured to optimize or improve proteins for specified functions. The problem space of such a task can grow quickly based on the sequence of the protein being optimized and the functions for which the protein is being designed. The solutions described herein allow the problem space to be efficiently searched by applying a combination of a protein design pipeline and an evaluation procedure performed on a quantum computer. As a result, single or multiple amino acid substitutions at a site of interest may be predicted in order to generate optimized protein variants.

公开(公告)号：US11542487B2

公开(公告)日：2023-01-03

申请号：US16757993

申请日：2018-10-17

Applicant: BASF SE

Inventor： Hugo Urbina ,  Tong Li ,  Jared Dennis ,  Xuqiu Tan ,  Adrienne Huston Davenport ,  Jochen Kutscher ,  Kristine W. Chang

IPC: C12N9/26

Abstract: Variant polypeptides having beta-amylase activity and methods of making and using the enzymes in baking, detergents, personal care products, in the processing of textiles, in pulp and paper processing, in the production of ethanol, lignocellulosic ethanol, or syrups; as viscosity breakers in oilfield and mining industries.

公开(公告)号：US20220162576A1

公开(公告)日：2022-05-26

申请号：US17442489

申请日：2020-03-24

Applicant: BASF SE

Inventor： Stefan Jenewein ,  Zachary David Miles ,  Asfia Qureshi ,  Jared Dennis ,  Tong Li ,  Xuqiu Tan ,  Priya Anand ,  Jesper Nielsen

IPC: C12N9/28

Abstract: Genetically engineered enzymes having amylase enzyme activity, compositions comprising the enzymes, and methods of making and using the enzymes. Fragments of parent amylase enzymes activity and methods of using the fragments for making genetically engineered enzymes having amylase activity. The genetically engineered amylase enzymes are useful in many different applications such as laundry detergents, dish washing detergents, and cleaning products for homes, industry, vehicle care, baking, animal feed, pulp and paper processing, starch processing, brewing, and ethanol production.