-
公开(公告)号：US11970498B2
公开(公告)日：2024-04-30
申请号：US18166178
申请日：2023-02-08
发明人： Douglas Wilson , Neil Bifulco, Jr. , Natasja Brooijmans , Joseph L. Kim , Philip D. Ramsden , Richard Vargas , Steven Mark Wenglowsky
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K45/06 , A61P35/00 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00 , C07B2200/05
摘要： The present disclosure provides a compound represented by structural Formula (I):
or a pharmaceutically acceptable salt thereof useful for treating a cancer.-
公开(公告)号：US10370379B2
公开(公告)日：2019-08-06
申请号：US15355425
申请日：2016-11-18
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
摘要： This disclosure relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants, such as compounds of Formula I:
-
公开(公告)号：US20170145018A1
公开(公告)日：2017-05-25
申请号：US15355425
申请日：2016-11-18
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.
-
公开(公告)号：US20170029409A1
公开(公告)日：2017-02-02
申请号：US15295450
申请日：2016-10-17
发明人： Lucian V. DiPietro , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu , Steven Mark Wenglowsky , Douglas Wilson , Yulian Zhang
IPC分类号： C07D403/14 , C07D487/04 , C07D413/14 , C07D409/14 , C07D487/08 , C07D405/14 , C07D473/34 , C07D401/14
CPC分类号： C07D403/14 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D487/04 , C07D487/08 , C07D487/22
摘要： Compounds and compositions useful for treating disorders related to Kit are described herein.
摘要翻译： 本文描述了可用于治疗与Kit相关的疾病的化合物和组合物。
-
公开(公告)号：US20190382410A1
公开(公告)日：2019-12-19
申请号：US16527773
申请日：2019-07-31
IPC分类号： C07D487/04
摘要： This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.
-
公开(公告)号：US11932648B2
公开(公告)日：2024-03-19
申请号：US17850453
申请日：2022-06-27
发明人： Douglas Wilson , Neil Bifulco, Jr. , Natasja Brooijmans , Joseph L. Kim , Emanuele Perola , Philip D. Ramsden , Richard Vargas , Steven Mark Wenglowsky
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K45/06 , A61P35/00 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00 , C07B2200/05
摘要： The present disclosure provides a compound represented by structural Formula (I):
or a pharmaceutically acceptable salt thereof useful for treating a cancer.-
公开(公告)号：US11059827B2
公开(公告)日：2021-07-13
申请号：US16527773
申请日：2019-07-31
IPC分类号： C07D487/04 , A61P35/02
摘要： This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.
-
公开(公告)号：US11046697B2
公开(公告)日：2021-06-29
申请号：US16027166
申请日：2018-07-03
IPC分类号： C07D487/04 , A61P35/04 , A61K31/519 , A61P35/02
摘要： This disclosure relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants, such as compounds of Formula (I):
-
公开(公告)号：US10202365B2
公开(公告)日：2019-02-12
申请号：US15548925
申请日：2016-02-05
发明人： Natasja Brooijmans , Lucian V. DiPietro , Paul E. Fleming , Joseph L. Kim , Steven Mark Wenglowsky , Yulian Zhang
IPC分类号： A61K31/506 , C07D401/14 , C07D403/12 , C07D405/14 , C07D403/04 , C07D417/14 , A61K45/06
摘要： Described herein are compounds, such as compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions, e.g., for treating a condition mediated by aberrant RET activity
-
公开(公告)号：US20230322791A1
公开(公告)日：2023-10-12
申请号：US18166178
申请日：2023-02-08
发明人： Douglas Wilson , Neil Bifulco, JR. , Natasja Brooijmans , Joseph L. Kim , Emanuele Perola , Philip D. Ramsden , Richard Vargas , Steven Mark Wenglowsky
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00 , C07B2200/05
摘要： The present disclosure provides a compound represented by structural Formula (I):
or a pharmaceutically acceptable salt thereof useful for treating a cancer.
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.023 秒)
