公开(公告)号：US20230140430A1

公开(公告)日：2023-05-04

申请号：US17792887

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Matthew COX ,  Liqi HE ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Matthias BROEKEMA ,  Qiang CONG ,  Daniel O'MALLEY ,  Yam B. POUDEL ,  Christine M. TARBY

IPC: C07D519/00 ,  A61K45/06

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230122249A1

公开(公告)日：2023-04-20

申请号：US17793162

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Matthew COX ,  Liqi HE ,  Daniel O'MALLEY ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Matthias BROEKEMA ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH,Murugaiah

IPC: C07D487/04 ,  C07D519/00

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.