公开(公告)号：US20180110873A1

公开(公告)日：2018-04-26

申请号：US15789027

申请日：2017-10-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ivar M. MCDONALD ,  Prasanna SIVAPRAKASAM ,  Christiana I. IWUAGWU ,  Kevin M. Peese ,  Heng CHENG ,  Naidu S. CHOWDARI ,  Sanjeev GANGWAR

IPC: A61K47/68 ,  C07F7/08 ,  C07K5/062 ,  C07D471/04 ,  C07D519/00

CPC classification number: A61K47/6803 ,  C07D471/04 ,  C07D519/00 ,  C07F7/0814 ,  C07K5/06026

Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.

公开(公告)号：US10398783B2

公开(公告)日：2019-09-03

申请号：US15789027

申请日：2017-10-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ivar M. McDonald ,  Prasanna Sivaprakasam ,  Christiana I. Iwuagwu ,  Kevin M. Peese ,  Heng Cheng ,  Naidu S. Chowdari ,  Sanjeev Gangwar

IPC: C07D471/04 ,  A61K47/68 ,  C07D519/00 ,  C07F7/08 ,  C07K5/062

Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.