公开(公告)号：US10683357B2

公开(公告)日：2020-06-16

申请号：US15474731

申请日：2017-03-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zhehong Cai ,  Indrani Chakraborty ,  Marie-Michelle Navarro Garcia ,  Thomas D. Kempe ,  Alan J. Korman ,  Alexander T. Kozhich ,  Hadia Lemar ,  Mark Maurer ,  Christina Maria Milburn ,  Michael Quigley ,  Xiang Shao ,  Mohan Srinivasan ,  Kent Thudium ,  Susan Chien-Szu Wong ,  Jochem Gokemeijer ,  Xi-Tao Wang ,  Han Chang ,  Patrick Guirnalda

IPC: C07H21/04 ,  C12P21/06 ,  C12N15/87 ,  C12N1/20 ,  C12N5/20 ,  C12N15/00 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  A61K39/395 ,  G01N33/574 ,  A61K39/00

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US11466092B2

公开(公告)日：2022-10-11

申请号：US16847130

申请日：2020-04-13

Applicant: Bristol-Myers Squibb Company

Inventor： Zhehong Cai ,  Indrani Chakraborty ,  Marie-Michelle Navarro Garcia ,  Thomas D. Kempe ,  Alan J. Korman ,  Alexander T. Kozhich ,  Hadia Lemar ,  Mark Maurer ,  Christina Maria Milburn ,  Michael Quigley ,  Xiang Shao ,  Mohan Srinivasan ,  Kent Thudium ,  Susan Chien-Szu Wong ,  Jochem Gokemeijer ,  Xi-Tao Wang ,  Han Chang ,  Patrick Guirnalda

IPC: A61K39/00 ,  A61K39/395 ,  G01N33/53 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  G01N33/574

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US09644032B2

公开(公告)日：2017-05-09

申请号：US15166114

申请日：2016-05-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zhehong Cai ,  Indrani Chakraborty ,  Marie-Michelle Navarro Garcia ,  Thomas D. Kempe ,  Alan J. Korman ,  Alexander T. Kozhich ,  Hadia Lemar ,  Mark Maurer ,  Christina Maria Milburn ,  Michael Quigley ,  Xiang Shao ,  Mohan Srinivasan ,  Kent Thudium ,  Susan Chien-Szu Wong ,  Jochem Gokemeijer ,  Xi-Tao Wang ,  Han Chang ,  Patrick Guirnalda

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/574

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.