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公开(公告)号：US12194110B2
公开(公告)日：2025-01-14
申请号：US17483393
申请日：2021-09-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Paul E. Morin , David Donnelly , Dasa Lipovsek , Jochem Gokemeijer , Maria N. Jure-Kunkel , David Fabrizio , Martin C. Wright , Douglas Dischino , Samuel J. Bonacorsi, Jr. , Ralph Adam Smith , Virginie Lafont , Daniel Cohen
Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.
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公开(公告)号：US11173219B2
公开(公告)日：2021-11-16
申请号：US16520965
申请日：2019-07-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Paul E. Morin , David Donnelly , Dasa Lipovsek , Jochem Gokemeijer , Maria Jure-Kunkel , David Fabrizio , Martin C. Wright , Douglas Dischino , Samuel J. Bonacorsi, Jr. , Ralph Adam Smith , Virginie LaFont , Daniel Cohen
Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.
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公开(公告)号：US09644032B2
公开(公告)日：2017-05-09
申请号：US15166114
申请日：2016-05-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zhehong Cai , Indrani Chakraborty , Marie-Michelle Navarro Garcia , Thomas D. Kempe , Alan J. Korman , Alexander T. Kozhich , Hadia Lemar , Mark Maurer , Christina Maria Milburn , Michael Quigley , Xiang Shao , Mohan Srinivasan , Kent Thudium , Susan Chien-Szu Wong , Jochem Gokemeijer , Xi-Tao Wang , Han Chang , Patrick Guirnalda
IPC: C07K16/28 , A61K39/395 , C07K16/30 , A61K39/00
CPC classification number: C07K16/2878 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/30 , C07K16/3023 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/574
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：US11466092B2
公开(公告)日：2022-10-11
申请号：US16847130
申请日：2020-04-13
Applicant: Bristol-Myers Squibb Company
Inventor： Zhehong Cai , Indrani Chakraborty , Marie-Michelle Navarro Garcia , Thomas D. Kempe , Alan J. Korman , Alexander T. Kozhich , Hadia Lemar , Mark Maurer , Christina Maria Milburn , Michael Quigley , Xiang Shao , Mohan Srinivasan , Kent Thudium , Susan Chien-Szu Wong , Jochem Gokemeijer , Xi-Tao Wang , Han Chang , Patrick Guirnalda
IPC: A61K39/00 , A61K39/395 , G01N33/53 , C07K16/28 , C07K16/30 , A61P35/00 , G01N33/574
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：US10995131B2
公开(公告)日：2021-05-04
申请号：US15826196
申请日：2017-11-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07K19/00 , C40B40/08 , C40B40/10 , C12N15/10 , C12N15/09 , A61K38/39 , C07H21/04 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
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Patent Agency Ranking
公开(公告)号：US09328157B2
公开(公告)日：2016-05-03
申请号：US14071069
申请日：2013-11-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07H21/04 , C12N15/09 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30 , A61K38/39 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
Abstract translation: 本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。 本公开还提供了与单结构域结合多肽相关的各种改进。
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公开(公告)号：US09862758B2
公开(公告)日：2018-01-09
申请号：US15070572
申请日：2016-03-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07H21/04 , C12N15/09 , C07K19/00 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30 , A61K38/39 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
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公开(公告)号：US11344639B2
公开(公告)日：2022-05-31
申请号：US16305284
申请日：2017-05-31
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Paul E. Morin , David Donnelly , Dasa Lipovsek , Jochem Gokemeijer , Maria Jure-Kunkel , David Fabrizio , Martin C. Wright , Douglas Dischino , Samuel J. Bonacorsi, Jr. , Ralph Adam Smith , Virginie Lafont , Daniel Cohen , David K. Leung
Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.
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公开(公告)号：US10683357B2
公开(公告)日：2020-06-16
申请号：US15474731
申请日：2017-03-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zhehong Cai , Indrani Chakraborty , Marie-Michelle Navarro Garcia , Thomas D. Kempe , Alan J. Korman , Alexander T. Kozhich , Hadia Lemar , Mark Maurer , Christina Maria Milburn , Michael Quigley , Xiang Shao , Mohan Srinivasan , Kent Thudium , Susan Chien-Szu Wong , Jochem Gokemeijer , Xi-Tao Wang , Han Chang , Patrick Guirnalda
IPC: C07H21/04 , C12P21/06 , C12N15/87 , C12N1/20 , C12N5/20 , C12N15/00 , C07K16/28 , C07K16/30 , A61P35/00 , A61K39/395 , G01N33/574 , A61K39/00
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：US10406251B2
公开(公告)日：2019-09-10
申请号：US15529260
申请日：2015-11-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Paul E. Morin , David Donnelly , Dasa Lipovsek , Jochem Gokemeijer , Maria N. Jure-Kunkel , David Fabrizio , Martin C. Wright , Douglas Dischino , Samuel J. Bonacorsi, Jr. , Ralph Adam Smith , Virginie Lafont , Daniel Cohen
IPC: A61K51/08 , C07K14/78 , G01N33/60 , G01N33/68 , G01N33/574
Abstract: Provided herein are novel polypeptides comprising fibronectin type III tenth (10Fn3) domains which specifically bind to Programmed Death Ligand-1 (PD-L1), as well as imaging agents based on the same for diagnostics.
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