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公开(公告)号：US20230119066A1
公开(公告)日：2023-04-20
申请号：US17914257
申请日：2021-03-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ruth Yin-Zong Lan , Olufemi A. Adelakun , Ishita Barman , Joseph Campbell , SJ Jian Zhe Diong , Felix Findeisen , Danielle M. Greenawalt , Renu Jain , Amy D. Jhatakia , John K. Lee , Peter S.K. Lee , Linda Liang , Kai Lu , Bryan McDonald , Paul Mesko , Arvind Rajpal , Sharmila Sambanthamoorthy , Mark J. Selby , Nathan O. Siemers , Pavel Strop , Gaby A. Terracina , Xi-Tao Wang
Abstract: This disclosure provides isolated antibodies, for example, monoclonal antibodies, that specifically bind to the C-C Motif Chemokine Receptor 8 (CCR8) expressed on the surface of a cell and mediate depletion of the CCR8-expressing cell by anti-body-dependent cellular cytotoxicity (ADCC). The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CCR8 antibody as monotherapy or in combination with an anti-cancer agent such as an immune checkpoint inhibitor, for example, an anti-PD-1 or anti-PD-L1 antibody.
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公开(公告)号：US11408889B2
公开(公告)日：2022-08-09
申请号：US16870006
申请日：2020-05-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Xi-Tao Wang , Olufemi A. Adelakun , Anne C. Lewin , Alan J. Korman , Mark J. Selby , Changyu Wang , Haichun Huang , Karla A. Henning , Nils Lonberg , Mohan Srinivasan , Michelle Minhua Han , Guodong Chen , Richard Y. Huang , Indrani Chakraborty , Susan Chien-Szu Wong , Huiming Li
IPC: G01N33/566 , G01N33/574 , C07K16/28
Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.
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公开(公告)号：US10690674B2
公开(公告)日：2020-06-23
申请号：US15578874
申请日：2016-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Xi-Tao Wang , Olufemi A. Adelakun , Anne C. Lewin , Alan J. Korman , Mark J. Selby , Changyu Wang , Haichun Huang , Karla A. Henning , Nils Lonberg , Mohan Srinivasan , Michelle Minhua Han , Guodong Chen , Richard Y. Huang , Indrani Chakraborty , Susan Chien-Szu Wong , Huiming Li
IPC: G01N33/566 , G01N33/574 , C07K16/28
Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.
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