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    Skin lightening agents, compositions and methods
    2.
    发明授权
    Skin lightening agents, compositions and methods 有权
    护肤剂，组合物和方法

    公开(公告)号：US06852310B2

    公开(公告)日：2005-02-08

    申请号：US10227642

    申请日：2002-08-23

    申请人： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko

    发明人： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko

    IPC分类号： A61K8/42 ,  A61Q19/02 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44

    CPC分类号： A61Q19/02 ,  A61K8/42

    摘要： Cosmetic methods of skin lightening using coumarin derivatives of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, cycloalkyl, cycloalkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups; Each or both R3 and/or R4, which may be connected by a single or double carbon-carbon bond (shown as a dotted line), represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, alkoxy, cycloalkyl, or cycloalkenyl group; and Each or both R5 and/or R6 represents a hydrogen atom, OH, C1-C4 acyl group, C1-C4 alkyl group, O—CO—R7, O—COO—R8 group, mesyl group or tosyl group, where each or both R7 and/or R8 represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups.

    摘要翻译： 使用式I的香豆素衍生物作为皮肤增白剂单独使用或与其它皮肤有益剂组合以及与化妆品载体一起使用的美白方法：其中R1和/或R2各自表示氢; 直链或支链C 1 -C 18烷基，烯基，环烷基，环烯基，羟基烷基，羟基烯基，酰基，环酰基或烷氧基;可以通过单或双碳 - 碳键连接的各个或两个R 3和/或R 4 作为虚线）表示氢; 直链或支链C 1 -C 18烷基，烯基，烷氧基，环烷基或环烯基; R 5和/或R 6中的每一个或两个表示氢原子，OH，C 1 -C 4酰基，C 1 -C 4烷基，O-CO-R 7，O-COO-R 8基，甲磺酰基或甲苯磺酰基， R7和/或R8表示氢; 直链或支链C 1 -C 18烷基，烯基，羟烷基，羟烯基，酰基，环酰基或烷氧基。

    Skin lightening agents, compositions and methods
    3.
    发明授权
    Skin lightening agents, compositions and methods 有权
    护肤剂，组合物和方法

    公开(公告)号：US07300646B2

    公开(公告)日：2007-11-27

    申请号：US10789293

    申请日：2004-02-27

    申请人： Bijan Harichian ,  Jose Rosa ,  Michael James Barratt ,  Carol Annette Bosko ,  John Steven Bajor

    发明人： Bijan Harichian ,  Jose Rosa ,  Michael James Barratt ,  Carol Annette Bosko ,  John Steven Bajor

    IPC分类号： A61Q19/02 ,  A61Q19/04 ,  A61K8/02 ,  A61K31/235

    CPC分类号： A61K8/365 ,  A61K8/37 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732

    摘要： Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

    摘要翻译： 披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或 杂烷基 和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或 杂芳基。 在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表 甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备 。 本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。 还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。

    Skin lightening agents, compositions and methods
    5.
    发明授权
    Skin lightening agents, compositions and methods 失效
    护肤剂，组合物和方法

    公开(公告)号：US06875425B2

    公开(公告)日：2005-04-05

    申请号：US10317484

    申请日：2002-12-12

    申请人： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Michael Tallman

    发明人： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Michael Tallman

    IPC分类号： A61K8/49 ,  A61Q19/02 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44

    CPC分类号： A61K8/4986 ,  A61K8/49 ,  A61Q19/02

    摘要： Cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Wherein X represents Carbon, Nitrogen, Sulfur or Oxygen; each A1 and/or A2 independently is =H or COR, CO2R, CONHR having the following formula A: where R=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is C1-C18 saturated or unsaturated hydrocarbon or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon.

    摘要翻译： 使用式I化合物作为皮肤增亮剂的化妆品组合物和皮肤发白方法：其中X表示碳，氮，硫或氧;每个A1和/或A2独立地为= H或COR，CO 2 R，CONHR，具有下式A： 其中R = C1-C18饱和或不饱和的直链或支链烃; Y 1和/或Y 2独立地是C 1 -C 18饱和或不饱和烃或OZ，其中Z = H或COR 1，CO 2 R 1，CONHR 1，其中R 1 = C1- C18饱和或不饱和的直链或支链烃。

    Cosmetic compositions containing Nigrospora sphaerica extracts
    7.
    发明授权
    Cosmetic compositions containing Nigrospora sphaerica extracts 有权
    含有孢子孢子提取物的化妆品组合物

    公开(公告)号：US07396534B2

    公开(公告)日：2008-07-08

    申请号：US10843489

    申请日：2004-05-11

    申请人： John Steven Bajor ,  Michael James Barratt ,  Carol Annette Bosko

    发明人： John Steven Bajor ,  Michael James Barratt ,  Carol Annette Bosko

    IPC分类号： A61K36/06

    CPC分类号： A61K8/99 ,  A61Q19/02

    摘要： Disclosed are extracts of Nigrospora sphaerica as cosmetic skin benefit agents, preferably as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin, and are commercially available or cost-effective and available in nature.

    摘要翻译： 公开了作为化妆品皮肤有益剂的黑曲霉的提取物，优选单独使用作为皮肤增白剂或与其它皮肤有益剂组合，并与化妆品载体一起使用。 本发明的提取物，组合物和方法具有有效的皮肤发光特性，可以更容易地递送到皮肤，并且是商业上可获得的或成本有效的并且在自然界中可获得。

    Stabilization of sunscreens in cosmetic compositions
    8.
    发明授权
    Stabilization of sunscreens in cosmetic compositions 有权
    化妆品组合物中防晒剂的稳定化

    公开(公告)号：US06869598B2

    公开(公告)日：2005-03-22

    申请号：US10385914

    申请日：2003-03-11

    申请人： Arthur Ray Love ,  Judith Lynne Kerschner ,  Michael James Barratt ,  Yan Zhou ,  Prem Chandar

    发明人： Arthur Ray Love ,  Judith Lynne Kerschner ,  Michael James Barratt ,  Yan Zhou ,  Prem Chandar

    IPC分类号： A61K8/00 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K8/97 ,  A61Q17/04 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44

    CPC分类号： A61Q17/04 ,  A61K8/347 ,  A61K8/35 ,  A61K8/37 ,  A61K8/375

    摘要： Cosmetic compositions containing organic sunscreens along with a 4-substituted resorcinol derivatives of general formula I exhibit improved storage stability and oxidative stability: where each R1 and R2, independently, represents a hydrogen atom, —CO—R (acyl group), —COO—R CONHR; where R represents saturated or unsaturated, linear, branched or cyclic C1-C18 hydrocarbon groups; and R3 represents (1) an alkyl group, having from 1 to 18 carbon atoms, preferably having from 2 to 12 carbon atoms, with or without substitution of one or more hydrogen atoms of a linear alkyl group with a methyl or ethyl group; e.g., R3 constitutes linear or branched chain alkyls, or (2) a group of the general formula formula (II) Where X is preferably H, n is 0 to 3 and the dashed lines represents an optional double bond.

    摘要翻译： 含有有机防晒剂的化妆品组合物与通式I的4-取代间苯二酚衍生物具有改进的储存稳定性和氧化稳定性：其中每个R 1和R 2独立地表示氢原子，-CO-R（酰基），-COO- R CONHR; 其中R表示饱和或不饱和的直链，支链或环状的C 1 -C 18烃基; 和R 3表示（1）具有1至18个碳原子，优选具有2至12个碳原子的烷基，具有或不具有直链烷基的一个或多个氢原子与甲基或乙基的取代; 例如，R 3构成直链或支链烷基，或（2）通式（II）的基团其中X优选为H，n为0至3，虚线表示任选的双键。

    Stabilization of resorcinol derivatives in cosmetic compositions
    9.
    发明授权
    Stabilization of resorcinol derivatives in cosmetic compositions 有权
    化妆品组合物中间苯二酚衍生物的稳定化

    公开(公告)号：US06863897B2

    公开(公告)日：2005-03-08

    申请号：US10385955

    申请日：2003-03-11

    申请人： Arthur Ray Love ,  Judith Lynne Kerschner ,  Michael James Barratt ,  Yan Zhou

    发明人： Arthur Ray Love ,  Judith Lynne Kerschner ,  Michael James Barratt ,  Yan Zhou

    IPC分类号： A61K8/00 ,  A61K8/19 ,  A61K8/27 ,  A61K8/29 ,  A61K8/30 ,  A61K8/34 ,  A61K8/49 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/00 ,  A61K7/42 ,  A61K7/44

    CPC分类号： A61K8/27 ,  A61K8/19 ,  A61K8/29 ,  A61K8/347 ,  A61K2800/412 ,  A61K2800/52 ,  A61Q17/04 ,  A61Q19/00

    摘要： Cosmetic compositions containing a micronized metal oxide along with a 4-substituted resorcinol derivatives of the general formula I exhibit improved storage stability: where each R1 and R2, independently, represents a hydrogen atom, —CO—R (acyl group), —COO—R, CONHR; where R represents saturated or unsaturated, linear, branched or cyclic C1-C18 hydrocarbon groups; and R3 represents (1) an alkyl group, having from 1 to 18 carbon atoms, preferably having from 2 to 12 carbon atoms, with or without substitution of one or more hydrogen atoms of a linear alkyl group with a methyl or ethyl group; e.g., R3 constitutes linear or branched chain alkyls, or (2) a group of the general formula formula (II) Where X is preferably H, n is 0 to 3 and the dashed lines represents an optional double bond.

    摘要翻译： 包含微粉化金属氧化物的化妆品组合物与通式I的4-取代间苯二酚衍生物一起显示改进的储存稳定性：其中每个R 1和R 2独立地表示氢原子，-CO-R（酰基），-COO- R，CONHR; 其中R表示饱和或不饱和的直链，支链或环状的C 1 -C 18烃基; 和R 3表示（1）具有1至18个碳原子，优选具有2至12个碳原子的烷基，具有或不具有直链烷基的一个或多个氢原子与甲基或乙基的取代; 例如，R 3构成直链或支链烷基，或（2）通式（II）的基团其中X优选为H，n为0至3，虚线表示任选的双键。