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17 条记录 (耗时 0.026 秒)

    Skin lightening agents, compositions and methods
    3.
    发明授权
    Skin lightening agents, compositions and methods 失效
    护肤剂，组合物和方法

    公开(公告)号：US06875425B2

    公开(公告)日：2005-04-05

    申请号：US10317484

    申请日：2002-12-12

    申请人： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Michael Tallman

    发明人： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko ,  Michael Tallman

    IPC分类号： A61K8/49 ,  A61Q19/02 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44

    CPC分类号： A61K8/4986 ,  A61K8/49 ,  A61Q19/02

    摘要： Cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Wherein X represents Carbon, Nitrogen, Sulfur or Oxygen; each A1 and/or A2 independently is =H or COR, CO2R, CONHR having the following formula A: where R=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is C1-C18 saturated or unsaturated hydrocarbon or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon.

    摘要翻译： 使用式I化合物作为皮肤增亮剂的化妆品组合物和皮肤发白方法：其中X表示碳，氮，硫或氧;每个A1和/或A2独立地为= H或COR，CO 2 R，CONHR，具有下式A： 其中R = C1-C18饱和或不饱和的直链或支链烃; Y 1和/或Y 2独立地是C 1 -C 18饱和或不饱和烃或OZ，其中Z = H或COR 1，CO 2 R 1，CONHR 1，其中R 1 = C1- C18饱和或不饱和的直链或支链烃。

    Skin lightening agents, compositions and methods
    4.
    发明授权
    Skin lightening agents, compositions and methods 有权
    护肤剂，组合物和方法

    公开(公告)号：US06852310B2

    公开(公告)日：2005-02-08

    申请号：US10227642

    申请日：2002-08-23

    申请人： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko

    发明人： Bijan Harichian ,  Michael James Barratt ,  Carol Annette Bosko

    IPC分类号： A61K8/42 ,  A61Q19/02 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44

    CPC分类号： A61Q19/02 ,  A61K8/42

    摘要： Cosmetic methods of skin lightening using coumarin derivatives of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, cycloalkyl, cycloalkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups; Each or both R3 and/or R4, which may be connected by a single or double carbon-carbon bond (shown as a dotted line), represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, alkoxy, cycloalkyl, or cycloalkenyl group; and Each or both R5 and/or R6 represents a hydrogen atom, OH, C1-C4 acyl group, C1-C4 alkyl group, O—CO—R7, O—COO—R8 group, mesyl group or tosyl group, where each or both R7 and/or R8 represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups.

    摘要翻译： 使用式I的香豆素衍生物作为皮肤增白剂单独使用或与其它皮肤有益剂组合以及与化妆品载体一起使用的美白方法：其中R1和/或R2各自表示氢; 直链或支链C 1 -C 18烷基，烯基，环烷基，环烯基，羟基烷基，羟基烯基，酰基，环酰基或烷氧基;可以通过单或双碳 - 碳键连接的各个或两个R 3和/或R 4 作为虚线）表示氢; 直链或支链C 1 -C 18烷基，烯基，烷氧基，环烷基或环烯基; R 5和/或R 6中的每一个或两个表示氢原子，OH，C 1 -C 4酰基，C 1 -C 4烷基，O-CO-R 7，O-COO-R 8基，甲磺酰基或甲苯磺酰基， R7和/或R8表示氢; 直链或支链C 1 -C 18烷基，烯基，羟烷基，羟烯基，酰基，环酰基或烷氧基。

    Skin lightening agents, compositions and methods
    5.
    发明授权
    Skin lightening agents, compositions and methods 有权
    护肤剂，组合物和方法

    公开(公告)号：US07300646B2

    公开(公告)日：2007-11-27

    申请号：US10789293

    申请日：2004-02-27

    申请人： Bijan Harichian ,  Jose Rosa ,  Michael James Barratt ,  Carol Annette Bosko ,  John Steven Bajor

    发明人： Bijan Harichian ,  Jose Rosa ,  Michael James Barratt ,  Carol Annette Bosko ,  John Steven Bajor

    IPC分类号： A61Q19/02 ,  A61Q19/04 ,  A61K8/02 ,  A61K31/235

    CPC分类号： A61K8/365 ,  A61K8/37 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732

    摘要： Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

    摘要翻译： 披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或 杂烷基 和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或 杂芳基。 在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表 甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备 。 本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。 还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。