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公开(公告)号：US20190032105A1
公开(公告)日：2019-01-31
申请号：US16072712
申请日：2017-01-25
发明人： Christophe QUIRING , Christine FAVIER , Patrice SARFATI , Jean Francois MOUSCADET , Ronald LEBOFSKY , Rebecca DIEVART
摘要： Methods, compositions, and kits are provided for rapidly analyzing microbial growth and/or number in a plurality of water-in-oil emulsion droplets.
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公开(公告)号：US20210071173A1
公开(公告)日：2021-03-11
申请号：US17102111
申请日：2020-11-23
发明人： Ronald LEBOFSKY , Jeremy AGRESTI
IPC分类号： C12N15/10
摘要： Methods and compositions are provided herein for preparing high-throughput cDNA sequencing libraries.
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公开(公告)号：US20200071694A1
公开(公告)日：2020-03-05
申请号：US16687411
申请日：2019-11-18
发明人： Ronald LEBOFSKY , Jeremy AGRESTI
IPC分类号： C12N15/10
摘要： Methods and compositions are provided herein for preparing high-throughput cDNA sequencing libraries.
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公开(公告)号：US20230313278A1
公开(公告)日：2023-10-05
申请号：US18106189
申请日：2023-02-06
发明人： Ronald LEBOFSKY
IPC分类号： C12Q1/6834 , C12Q1/6855
CPC分类号： C12Q1/6834 , C12Q1/6855 , C12Q2565/1015 , C12Q2563/137
摘要： Methods and compositions for attaching cell-specific barcodes without formation of partitions is provided.
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公开(公告)号：US20210164036A1
公开(公告)日：2021-06-03
申请号：US17136824
申请日：2020-12-29
发明人： Ronald LEBOFSKY , Jennifer CHEW
IPC分类号： C12Q1/6869 , C12Q1/6855 , C12Q1/6862 , C12Q1/6876 , C12Q1/6848 , C12Q1/686 , C12N15/10 , C12N9/12 , C12Q1/6806
摘要： The methods and reagents are provided for barcoding and analysis of DNA samples using partition (e.g., droplet) technology while avoiding performing amplification in droplets.
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公开(公告)号：US20230383332A1
公开(公告)日：2023-11-30
申请号：US18203424
申请日：2023-05-30
发明人： Ronald LEBOFSKY , Josh SHINOFF , Adam M. McCOY , Man CHENG
IPC分类号： C12Q1/6806 , C12Q1/6869
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12N1/06
摘要： Methods of making and forming partitions in nanovials are provided.
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公开(公告)号：US20230235391A1
公开(公告)日：2023-07-27
申请号：US17962338
申请日：2022-10-07
发明人： Ronald LEBOFSKY , Jason BUENROSTRO
IPC分类号： C12Q1/6874
CPC分类号： C12Q1/6874 , C12Q1/6841
摘要： Methods and compositions for determining the proximity of two barcoding oligonucleotides (e.g., in a single partition or adjacent on a tissue section) using a determination of the presence of a 9 bp sequence resulting from tagmentation in different nucleic acid fragments linked to different barcoding oligonucleotides is provided.
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公开(公告)号：US20210317509A1
公开(公告)日：2021-10-14
申请号：US17236743
申请日：2021-04-21
发明人： Ronald LEBOFSKY , Jeremy AGRESTI
IPC分类号： C12Q1/6809 , G16B20/00 , C12Q1/6869
摘要： Methods and compositions for maintaining DNA contiguity for sequencing is provided.
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公开(公告)号：US20230390726A1
公开(公告)日：2023-12-07
申请号：US18233235
申请日：2023-08-11
发明人： Ronald LEBOFSKY , Nicholas HEREDIA
IPC分类号： B01J19/00 , C12Q1/6806
CPC分类号： B01J19/0046 , C12Q1/6806 , B01J2219/00547 , B01J2219/00596 , B01J2219/00722
摘要： Methods of generating a nucleic acid signature for identifying particles associated in a partition are provided. In one aspect, the method comprises: partitioning a sample into a plurality of partitions comprising a particle comprising a solid support surface, the solid support surface having a plurality of oligonucleotide primers conjugated thereon, wherein the oligonucleotide primers comprise a barcode sequence, and wherein the partitions have 0, 1, or more than 1 particles per partition; providing in a partition a substrate comprising a barcode sequence or repeating clonal barcode sequences; and in the partition, associating a first particle conjugated to oligonucleotide primers comprising a first barcode sequence and a second particle conjugated to oligonucleotide primers comprising a second barcode sequence to a barcode sequence from the substrate, thereby generating a nucleic acid signature for the particles in the partition.
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公开(公告)号：US20230151357A1
公开(公告)日：2023-05-18
申请号：US17986637
申请日：2022-11-14
发明人： Ronald LEBOFSKY
IPC分类号： C12N15/10 , C12Q1/6841
CPC分类号： C12N15/1065 , C12Q1/6841
摘要： Methods of measuring the genotype and phenotype of a cells are provided.
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