公开(公告)号：US20240033344A1

公开(公告)日：2024-02-01

申请号：US18036681

申请日：2021-11-15

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Kaushik Thanki ,  Isaac Hernan Esparza Borquez ,  Sebastian Hörner ,  Bulat Sydykov ,  Martin Kapp

IPC: A61K39/215 ,  A61K47/26 ,  A61K9/51 ,  A61K9/19

CPC classification number: A61K39/215 ,  A61K47/26 ,  A61K9/5123 ,  A61K9/5192 ,  A61K9/19 ,  A61K2039/55555

Abstract: The present disclosure relates generally to the field of pharmaceutical compositions comprising particles, in particular lipid nanoparticles (LNPs), and mRNA, methods for preparing and storing such pharmaceutical compositions, and the use of pharmaceutical compositions in therapy.

公开(公告)号：US20230414516A1

公开(公告)日：2023-12-28

申请号：US18036676

申请日：2021-11-15

Applicant: BioNTech SE

Inventor： Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Sumit Luthra ,  Serguei A. Tchessalov ,  Steffen Panzner ,  Christian Reinsch ,  Kaushik Thanki ,  Sukrut Somani

IPC: A61K9/19 ,  A61K9/16 ,  A61K9/51 ,  A61K31/7105

CPC classification number: A61K9/19 ,  A61K9/1694 ,  A61K9/1623 ,  A61K9/5123 ,  A61K31/7105

Abstract: This invention relates to enhanced stabilization and improved lyophilization methods of pharmaceutical substances.

公开(公告)号：US20240041785A1

公开(公告)日：2024-02-08

申请号：US18036679

申请日：2021-11-14

Applicant: BioNTech SE

Inventor： Steffen Panzner ,  Christian Reinsch ,  Kaushik Thanki ,  Sukrut Somani ,  Serguei A. Tchessalov ,  Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Sumit Luthra

IPC: A61K9/51 ,  A61K47/24 ,  A61K47/18 ,  A61K47/28 ,  A61K47/26 ,  A61K39/215

CPC classification number: A61K9/5123 ,  A61K47/24 ,  A61K47/18 ,  A61K47/28 ,  A61K9/5146 ,  A61K47/26 ,  A61K9/5192 ,  A61K39/215 ,  A61K2039/6018

Abstract: The present disclosure provides technologies relating to stabilization of lipid nanoparticle mRNA compositions (e.g., vaccines).

公开(公告)号：US20230414747A1

公开(公告)日：2023-12-28

申请号：US18036677

申请日：2021-11-15

Applicant: BioNTech SE

Inventor： Steffen Panzner ,  Ugur Sahin ,  Jorrit-Jan Krijger ,  Kaushik Thanki ,  Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Sumit Luthra ,  Serguei A. Tchessalov

IPC: A61K39/215 ,  A61K9/51 ,  A61P31/14

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61P31/14 ,  C12N2770/20034 ,  A61K2039/53

Abstract: The present disclosure relates generally to the field of lipid nanoparticle (LNP) compositions comprising RNA, methods for preparing and storing such compositions, and the use of such compositions in therapy.