公开(公告)号：US20250108008A1

公开(公告)日：2025-04-03

申请号：US18762297

申请日：2024-07-02

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Sebastian Hörner ,  Isaac Hernan Esparza Borquez ,  Thomas Michael Hiller ,  Ferdia Bates

IPC: A61K9/127 ,  A61K31/713 ,  A61K48/00 ,  B82Y5/00

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.

公开(公告)号：US20240033344A1

公开(公告)日：2024-02-01

申请号：US18036681

申请日：2021-11-15

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Kaushik Thanki ,  Isaac Hernan Esparza Borquez ,  Sebastian Hörner ,  Bulat Sydykov ,  Martin Kapp

IPC: A61K39/215 ,  A61K47/26 ,  A61K9/51 ,  A61K9/19

CPC classification number: A61K39/215 ,  A61K47/26 ,  A61K9/5123 ,  A61K9/5192 ,  A61K9/19 ,  A61K2039/55555

Abstract: The present disclosure relates generally to the field of pharmaceutical compositions comprising particles, in particular lipid nanoparticles (LNPs), and mRNA, methods for preparing and storing such pharmaceutical compositions, and the use of pharmaceutical compositions in therapy.

公开(公告)号：US12220484B2

公开(公告)日：2025-02-11

申请号：US17495104

申请日：2021-10-06

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Isaac Hernan Esparza Borquez

IPC: A61K9/127 ,  A61K9/00 ,  A61K31/713

Abstract: The present invention relates to aqueous lipid and/or liposome formulations with an increased chemical stability, to methods of preparing such aqueous formulations as well as to kits comprising them. The present invention further relates to methods of preparing lipid-based pharmaceutical compositions, to pharmaceutical compositions prepared by such methods and to methods of chemically stabilizing aqueous lipid and/or liposome formulations.

公开(公告)号：US12059498B2

公开(公告)日：2024-08-13

申请号：US17170826

申请日：2021-02-08

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Sebastian Hörner ,  Isaac Hernan Esparza Borquez ,  Thomas Michael Hiller ,  Ferdia Bates

IPC: A61K9/127 ,  A61K31/713 ,  B82Y5/00 ,  A61K48/00

CPC classification number: A61K9/1272 ,  A61K31/713 ,  A61K48/00 ,  B82Y5/00

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.