公开(公告)号：US20250002522A1

公开(公告)日：2025-01-02

申请号：US18702857

申请日：2022-10-21

Applicant: BioNTech SE ,  Consejo Superior de Investigaciones Científicas (CSIC)

Inventor： Jorge Moreno Herrero ,  Heinrich Haas ,  Stephanie Erbar ,  José Manuel García Fernández ,  Juan Manuel Benito Hernández ,  Jose Lopez Fernandez ,  Práxedes Sánchez Mellado

IPC: C07H15/04 ,  C07H1/00

Abstract: The present disclosure provides compositions comprising an oligosaccharide of formula (I), wherein said compositions are useful for delivery of certain agents, including, for example, nucleic acids.

公开(公告)号：US12150947B2

公开(公告)日：2024-11-26

申请号：US16957898

申请日：2019-01-10

Applicant: BioNTech SE ,  TRON—TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ GGMBH

Inventor： Ugur Sahin ,  Heinrich Haas ,  Annette Vogel ,  Stephanie Erbar ,  Kerstin Walzer ,  Anne Schlegel ,  Sebastian Hörner ,  Jorge Herrero Moreno ,  Thorsten Klamp ,  Sebastian Kreiter ,  Mustafa Diken ,  Phillip Heller

IPC: A61K31/70 ,  A61K9/00 ,  A61K35/763 ,  A61K47/18

Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine.

公开(公告)号：US20250108008A1

公开(公告)日：2025-04-03

申请号：US18762297

申请日：2024-07-02

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Sebastian Hörner ,  Isaac Hernan Esparza Borquez ,  Thomas Michael Hiller ,  Ferdia Bates

IPC: A61K9/127 ,  A61K31/713 ,  A61K48/00 ,  B82Y5/00

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.

公开(公告)号：US20250057944A1

公开(公告)日：2025-02-20

申请号：US18702860

申请日：2022-10-21

Applicant: BioNTech SE ,  Consejo Superior de Investigaciones Científicas (CSIC)

Inventor： Jorge Moreno Herrero ,  Heinrich Haas ,  Stephanie Erbar ,  José Manuel García Fernández ,  Juan Manuel Benito Hernández ,  Jose Lopez Fernandez

IPC: A61K39/385 ,  A61K39/00 ,  A61K39/04 ,  A61K39/145 ,  A61P37/04

Abstract: The present disclosure provides complexes comprising a cationic oligosaccharide and an RNA, wherein the cationic oligosaccharide comprises a plurality of cationic moieties bonded to a trehalose, a sucrose, or a gluco-n-oligosaccharide moiety, where n is 2-6, and a ratio of N/P in the complex is less than 20:1

公开(公告)号：US11559587B2

公开(公告)日：2023-01-24

申请号：US16578601

申请日：2019-09-23

Applicant: BioNTech SE ,  TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg—Universität Mainz gGmbH

Inventor： Ugur Sahin ,  Heinrich Haas ,  Sebastian Kreiter ,  Mustafa Diken ,  Daniel Fritz ,  Martin Meng ,  Lena Mareen Kranz ,  Kerstin Reuter

IPC: A61K48/00 ,  A61K39/00 ,  A61K9/127

Abstract: The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.

公开(公告)号：US12220484B2

公开(公告)日：2025-02-11

申请号：US17495104

申请日：2021-10-06

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Isaac Hernan Esparza Borquez

IPC: A61K9/127 ,  A61K9/00 ,  A61K31/713

Abstract: The present invention relates to aqueous lipid and/or liposome formulations with an increased chemical stability, to methods of preparing such aqueous formulations as well as to kits comprising them. The present invention further relates to methods of preparing lipid-based pharmaceutical compositions, to pharmaceutical compositions prepared by such methods and to methods of chemically stabilizing aqueous lipid and/or liposome formulations.

公开(公告)号：US12059498B2

公开(公告)日：2024-08-13

申请号：US17170826

申请日：2021-02-08

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Sebastian Hörner ,  Isaac Hernan Esparza Borquez ,  Thomas Michael Hiller ,  Ferdia Bates

IPC: A61K9/127 ,  A61K31/713 ,  B82Y5/00 ,  A61K48/00

CPC classification number: A61K9/1272 ,  A61K31/713 ,  A61K48/00 ,  B82Y5/00

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.

公开(公告)号：US20220249372A1

公开(公告)日：2022-08-11

申请号：US17727956

申请日：2022-04-25

Applicant: BioNTech SE ,  Tron-Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-University Mainz Gmb

Inventor： Hossam Hefesha ,  Ugur Sahin ,  Heinrich Haas ,  Sebastian Kreiter ,  Yves Hüsemann ,  Mustafa Diken ,  Kerstin Walzer

IPC: A61K9/107 ,  A61K9/127 ,  A61K48/00 ,  A61K31/675 ,  A61K31/7105 ,  A61K9/00 ,  A61K31/663 ,  A61K45/06 ,  A61K39/395 ,  A61P35/00 ,  A61K39/00 ,  A61K47/18 ,  A61K47/24

Abstract: The present invention relates to lipid particles comprising at least one cationic lipid, at least one water-soluble therapeutically effective compound and RNA. Further, the present invention relates to a pharmaceutical composition comprising such particles. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the particles.

公开(公告)号：US20240417418A1

公开(公告)日：2024-12-19

申请号：US18702855

申请日：2022-10-21

Applicant: BioNTech SE ,  Consejo Superior de Investigaciones Científicas

Inventor： Jorge Moreno Herrero ,  Heinrich Haas ,  Stephanie Erbar ,  José Manuel García Fernández ,  Juan Manuel Benito Hernández ,  Jose Lopez Fernandez ,  Práxedes Sánchez Mellado

IPC: C07H15/04 ,  A61K9/00 ,  A61K31/7105 ,  A61K47/54 ,  C07H1/00

Abstract: The present disclosure provides compounds, compositions, and complexes useful for delivery of certain agents, including, for example, nucleic acids.

公开(公告)号：US20240033344A1

公开(公告)日：2024-02-01

申请号：US18036681

申请日：2021-11-15

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Kaushik Thanki ,  Isaac Hernan Esparza Borquez ,  Sebastian Hörner ,  Bulat Sydykov ,  Martin Kapp

IPC: A61K39/215 ,  A61K47/26 ,  A61K9/51 ,  A61K9/19

CPC classification number: A61K39/215 ,  A61K47/26 ,  A61K9/5123 ,  A61K9/5192 ,  A61K9/19 ,  A61K2039/55555

Abstract: The present disclosure relates generally to the field of pharmaceutical compositions comprising particles, in particular lipid nanoparticles (LNPs), and mRNA, methods for preparing and storing such pharmaceutical compositions, and the use of pharmaceutical compositions in therapy.