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15 条记录 (耗时 0.04 秒)

    Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    1.
    发明授权
    Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids 失效
    取代的1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸

    公开(公告)号：US4886886A

    公开(公告)日：1989-12-12

    申请号：US223481

    申请日：1988-07-25

    申请人： Brian A. McKittrick ,  Alan H. Katz

    发明人： Brian A. McKittrick ,  Alan H. Katz

    IPC分类号： C07D491/04 ,  C07D491/052

    CPC分类号： C07D491/04

    摘要： Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

    摘要翻译： 其特征在于具有位置1-，4-，5-，6-，7-和8位上具有取代基的1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸核 - 被披露。 所述衍生物是有用的抗炎和止痛剂，并且还公开了它们的制备和使用方法。

    SYSTEM FOR THE EFFICIENT DISCOVERY OF NEW THERAPEUTIC DRUGS
    4.
    发明申请
    SYSTEM FOR THE EFFICIENT DISCOVERY OF NEW THERAPEUTIC DRUGS 审中-公开
    新治疗药物有效发现的系统

    公开(公告)号：US20140171332A1

    公开(公告)日：2014-06-19

    申请号：US14098404

    申请日：2013-12-05

    申请人： Alan H. Katz ,  Philip J. Farrelly

    发明人： Alan H. Katz ,  Philip J. Farrelly

    IPC分类号： G06F19/00

    CPC分类号： G16C20/60 ,  G16B35/00 ,  G16C20/50 ,  Y02A90/26

    摘要： The invention provides for carrying out 3-dimensional similarity searching by comparing a probe molecule to each member of a 3-dimensional database. The probe molecule is overlapped with each member of a database of molecules and then the database molecule is rotated and translates until its similarity with the probe molecule is maximized. The system can contain ten different scoring functions to rate the similarity between the two molecules. Each function employs different molecular features when scoring a particular comparison. Some methods are based on the relative shape of the two molecules, and some are based on the overlap of key atoms such as oxygen, nitrogen, sulfur, and/or halogens.

    摘要翻译： 本发明提供了通过将探针分子与三维数据库的每个成员进行比较来进行三维相似性搜索。 探针分子与分子数据库的每个成员重叠，然后数据库分子被旋转和平移，直到其与探针分子的相似性最大化。 该系统可以包含十个不同的评分函数来评估两个分子之间的相似性。 每个功能在划分特定比较时采用不同的分子特征。 一些方法基于两个分子的相对形状，一些方法基于诸如氧，氮，硫和/或卤素的关键原子的重叠。

    Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    6.
    发明授权
    Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids 失效
    取代的-8-烯基-1,3,4,9-四氢吡喃（3,4-b）吲哚-1-乙酸

    公开(公告)号：US4855445A

    公开(公告)日：1989-08-08

    申请号：US294705

    申请日：1989-01-09

    申请人： Alan H. Katz ,  Christopher A. Demerson

    发明人： Alan H. Katz ,  Christopher A. Demerson

    IPC分类号： C07D491/04 ,  C07D491/052

    CPC分类号： C07D491/04

    摘要： Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-,5-,6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.

    摘要翻译： 公开了具有在位置1-，5-，6-，7-和8-位置具有取代基的1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸核的吲哚衍生物。 所述衍生物是有用的抗炎和/或止痛剂。 还公开了其制备和使用方法。

    Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
    10.
    发明授权
    Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids 失效
    取代的1,3,4,9-四氢吡喃（3,4-b）吲哚-1-乙酸

    公开(公告)号：US4971960A

    公开(公告)日：1990-11-20

    申请号：US299169

    申请日：1989-02-14

    申请人： Alan H. Katz ,  Christopher A. Demerson ,  Leslie G. Humber

    发明人： Alan H. Katz ,  Christopher A. Demerson ,  Leslie G. Humber

    IPC分类号： C07D491/04

    CPC分类号： C07D491/04

    摘要： Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

    摘要翻译： 其特征在于具有在位置1和4具有取代基的1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸核。所述核可以任选地在5,6位， 衍生物是有用的抗炎和止痛剂，并且还公开了它们的制备和使用方法。