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公开(公告)号：US20140005169A1
公开(公告)日：2014-01-02
申请号：US13990906
申请日：2011-12-02
申请人： Brian K. Albrecht , James Edmund Audia , Alexandre Cote , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Naveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Cote , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Naveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： C07D513/20 , C07D498/10 , C07D487/10 , C07D495/22 , C07D495/14 , C07D495/20
CPC分类号： C07D513/20 , C07D487/10 , C07D495/14 , C07D495/20 , C07D495/22 , C07D498/04 , C07D498/10 , C07D498/14 , C07D513/14
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20140296243A1
公开(公告)日：2014-10-02
申请号：US14126877
申请日：2012-06-15
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04 , A61K31/5025
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US09328117B2
公开(公告)日：2016-05-03
申请号：US14126877
申请日：2012-06-15
IPC分类号： A61K31/5025 , C07D487/04
CPC分类号： C07D487/04 , A61K31/5025
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20140371206A1
公开(公告)日：2014-12-18
申请号：US14313148
申请日：2014-06-24
申请人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20140135316A1
公开(公告)日：2014-05-15
申请号：US14114983
申请日：2012-05-04
申请人： Brian K. Albrecht , Victor S. Gehling , Michael C. Hewitt , Alexander M. Taylor , Jean-Christophe Harmange
发明人： Brian K. Albrecht , Victor S. Gehling , Michael C. Hewitt , Alexander M. Taylor , Jean-Christophe Harmange
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09249161B2
公开(公告)日：2016-02-02
申请号：US13990906
申请日：2011-12-02
申请人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： C07D513/20 , C07D498/10 , C07D487/10 , C07D495/22 , C07D495/14 , C07D495/20 , C07D498/04 , C07D498/14 , C07D513/14
CPC分类号： C07D513/20 , C07D487/10 , C07D495/14 , C07D495/20 , C07D495/22 , C07D498/04 , C07D498/10 , C07D498/14 , C07D513/14
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US08796261B2
公开(公告)日：2014-08-05
申请号：US13309646
申请日：2011-12-02
申请人： Brian K. Albrecht , James E. Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael C. Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James E. Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael C. Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： A61K31/55 , C07D498/04 , C07D498/20 , C07K14/47 , C07D498/14 , C07D498/22
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20120157428A1
公开(公告)日：2012-06-21
申请号：US13309646
申请日：2011-12-02
申请人： Brian K. Albrecht , James E. Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael C. Hewitt , Yves LeBlanc , Christopher G. Naveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James E. Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael C. Hewitt , Yves LeBlanc , Christopher G. Naveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： A61K31/55 , C07D498/14 , C07D498/22 , C07D498/20 , A61P35/00 , A61P29/00 , A61P31/00 , A61P37/00 , A61P31/12 , A61P35/02 , A61P19/02 , A61P17/06 , A61P1/00 , C12N9/99 , A61K31/551 , C07D498/04
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US09422292B2
公开(公告)日：2016-08-23
申请号：US14114983
申请日：2012-05-04
申请人： Brian K. Albrecht , Victor S. Gehling , Michael Charles Hewitt , Alexander M. Taylor , Jean-Christophe Harmange
发明人： Brian K. Albrecht , Victor S. Gehling , Michael Charles Hewitt , Alexander M. Taylor , Jean-Christophe Harmange
IPC分类号： A61K31/551 , C07D471/14 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20110118285A1
公开(公告)日：2011-05-19
申请号：US12994068
申请日：2009-05-22
申请人： Brian K. Albrecht , Steven Bellon , Christiane Bode , Alessandro Boezio , Deborah Choquette , Jean-Christophe Harmange
发明人： Brian K. Albrecht , Steven Bellon , Christiane Bode , Alessandro Boezio , Deborah Choquette , Jean-Christophe Harmange
IPC分类号： A61K31/519 , C07D498/02 , A61K31/437 , A61P35/00 , A61P35/04
CPC分类号： C07D471/04
摘要： Selected fused imidazole or triazole derivatives are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 选择的稠合咪唑或三唑衍生物可有效预防和治疗诸如HGF介导的疾病之类的疾病。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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