公开(公告)号：US20190314001A1

公开(公告)日：2019-10-17

申请号：US16387259

申请日：2019-04-17

Applicant: California Institute of Technology

Inventor： David Maresca ,  Daniel P. Sawyer ,  Mikhail Shapiro

IPC: A61B8/08 ,  A61B8/00 ,  A61B8/14

Abstract: Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems.

公开(公告)号：US20210353439A1

公开(公告)日：2021-11-18

申请号：US17318821

申请日：2021-05-12

Applicant: California Institute of Technology ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  CNRS-CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris

Inventor： Sumner L Norman ,  David Maresca ,  Vasileios Christopoulos ,  Mikhail Shapiro ,  Richard A. Andersen ,  Mickael Tanter ,  Charlie Demene

IPC: A61F2/70 ,  A61B8/06 ,  A61F4/00 ,  A61N1/08 ,  G16H30/40 ,  G06N20/00

Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.

公开(公告)号：US11944848B2

公开(公告)日：2024-04-02

申请号：US17816373

申请日：2022-07-29

Applicant: California Institute of Technology

Inventor： Avinoam D. Bar-Zion ,  Atousa Nourmahnad ,  David Maresca ,  Mikhail Shapiro

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0082

Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.

公开(公告)号：US11446523B2

公开(公告)日：2022-09-20

申请号：US16833637

申请日：2020-03-29

Applicant: California Institute of Technology

Inventor： Avinoam D. Bar-Zion ,  Atousa Nourmahnad ,  David Maresca ,  Mikhail Shapiro

IPC: A61N7/00

Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.

公开(公告)号：US11350909B2

公开(公告)日：2022-06-07

申请号：US16387259

申请日：2019-04-17

Applicant: California Institute of Technology

Inventor： David Maresca ,  Daniel P. Sawyer ,  Mikhail Shapiro

IPC: A61B8/08 ,  A61B8/14 ,  A61B8/00

Abstract: Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems configured to excite a first subaperture of transducer elements to transmit a first ultrasound plane wave, excite a second subaperture of transducer elements to transmit a second ultrasound plane wave noncollinear to the first ultrasound plane wave, the second ultrasound plane wave axisymmetric to the first ultrasound plane wave about a bisector, and simultaneously excite both first and second subapertures to transmit first and second ultrasound plane waves to cause an acoustic pressure above a threshold along the bisector.

公开(公告)号：US12109440B2

公开(公告)日：2024-10-08

申请号：US17816373

申请日：2022-07-29

Applicant: California Institute of Technology

Inventor： Avinoam D. Bar-Zion ,  Atousa Nourmahnad ,  David Maresca ,  Mikhail Shapiro

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0082

Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.