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公开(公告)号：US20080299109A1
公开(公告)日：2008-12-04
申请号：US12022510
申请日：2008-01-30
CPC分类号： G01N33/5058 , G01N2333/70571 , G01N2333/726
摘要： The present invention relates to a novel communication mechanism between astrocytes and neurons at a synapse. More specifically, the present invention relates to a signaling mechanism between astrocytes and neurons, by activating astrocytic G-protein coupled receptors, thereby activating glutamate receptors on a membrane of neighboring postsynaptic neurons, resulting in increasing the level of intracellular Ca2+ and inducing a depolarization inward current to control neurotransmission in neurons.
摘要翻译： 本发明涉及星形胶质细胞和突触间神经元之间的新型通讯机制。 更具体地说，本发明涉及星形胶质细胞和神经元之间的信号传导机制，通过激活星形细胞G蛋白偶联受体，从而激活相邻突触后神经元膜上的谷氨酸受体，导致细胞内Ca 2+的水平升高并引起向内的去极化 目前用于控制神经元中的神经传递。
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2.发明授权Ultra sensitive biosensor for detecting bio-signal transmitters, and detector and detecting method using the same 有权用于检测生物信号发射器的超灵敏生物传感器，以及使用其的检测器和检测方法公开(公告)号：US07842471B2
公开(公告)日：2010-11-30
申请号：US12022442
申请日：2008-01-30
申请人： Changjoon Justin Lee , Dong-Ho Woo
发明人： Changjoon Justin Lee , Dong-Ho Woo
IPC分类号： G01N33/53
CPC分类号： G01N33/48721 , G01N2333/70571
摘要： The present invention relates to a novel use of a transfected cell as a biosensor, wherein the transfected cell expresses a receptor specific to a bio-signal transmitter, and a highly sensitive detector and a highly sensitive detecting method of a bio-signal transmitter using the biosensor. The bio-signal transmitter detecting technique according to the present invention has an advantage of being applied to a sniffer-patch method, and is capable of providing millisecond time resolution for detecting nanomolar levels of the bio-signal transmitter to be detected.
摘要翻译： 本发明涉及一种转染细胞作为生物传感器的新用途，其中转染的细胞表达对生物信号发射器特异的受体，以及高灵敏度的检测器和使用该方法的生物信号发射器的高灵敏度检测方法 生物传感器 根据本发明的生物信号发射器检测技术具有应用于嗅探器贴片方法的优点，并且能够提供用于检测要检测的生物信号发射器的纳摩尔级的毫秒时间分辨率。
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公开(公告)号：US20120232127A1
公开(公告)日：2012-09-13
申请号：US13418486
申请日：2012-03-13
IPC分类号： A61K31/7088 , A61K31/26 , A61K31/196 , A61P25/00 , A61K31/44
CPC分类号： C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： A novel use of anion channels, preferably Ca2+-activated anion channels (CAACs), in regulating release of neurotransmitters from neurons and/or astrocytes is provided. More specifically, CAAC activity regulators, agents for regulating neurotransmitter release comprising such CAAC activity regulators, and methods of screening agents for regulating neurotransmitter release using CAAC as a target.
摘要翻译： 提供阴离子通道，优选Ca2 +活化阴离子通道（CAAC）在调节神经元和/或星形胶质细胞释放神经递质中的新用途。 更具体地，CAAC活性调节剂，用于调节包含这种CAAC活性调节剂的神经递质释放剂，以及使用CAAC作为靶标调节神经递质释放调节剂的方法。
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公开(公告)号：US20110201668A1
公开(公告)日：2011-08-18
申请号：US12865126
申请日：2008-01-30
IPC分类号： A61K31/7088 , C07H21/02 , C12N15/63 , C12Q1/02 , C12Q1/68
CPC分类号： C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： A novel use of anion channels, preferably Ca2+-activated anion channels (CAACs), in regulating release of neurotransmitters from neurons and/or astrocytes is provided. More specifically, CAAC activity regulators, agents for regulating neurotransmitter release comprising such CAAC activity regulators, and methods of screening agents for regulating neurotransmitter release using CAAC as a target.
摘要翻译： 提供阴离子通道，优选Ca2 +活化阴离子通道（CAAC）在调节神经元和/或星形胶质细胞释放神经递质中的新用途。 更具体地，CAAC活性调节剂，用于调节包含这种CAAC活性调节剂的神经递质释放剂，以及使用CAAC作为靶标调节神经递质释放调节剂的方法。
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公开(公告)号：US06838099B2
公开(公告)日：2005-01-04
申请号：US10168644
申请日：2001-10-18
申请人： Dong-Ho Woo , Jin-Keun Kim
发明人： Dong-Ho Woo , Jin-Keun Kim
IPC分类号： A23L7/10 , A23L29/262 , D21C3/02 , D21C1/00
CPC分类号： C12Y302/01004 , A23L7/115 , A23L29/262 , C12Y302/01021
摘要： The present invention relates to a high yield process for producing soluble dietary fiber from corn hull. More specifically, the present invention comprises removing starch and protein with enzymes from corn hull which is by-product of wet-milling process for production of corn starch, extracting the resultant with alkaline solution to form a alkaline extract, treating the alkaline extract with enzymes, and drying the enzyme-treated solution, to produce dietary fiber with low viscosity and containing hemicellulose as a major component at high yield.
摘要翻译： 本发明涉及从玉米壳生产可溶性膳食纤维的高产率方法。 更具体地说，本发明包括从玉米壳中除去淀粉和蛋白质，其是用于生产玉米淀粉的湿法研磨的副产物，用碱性溶液萃取生成碱性提取物，用酶处理碱性提取物 并干燥酶处理溶液，生产低粘度的膳食纤维，并以高产率含有半纤维素作为主要成分。
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