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    GENE EXPRESSION PROFILES TO PREDICT BREAST CANCER OUTCOMES
    4.
    发明申请
    GENE EXPRESSION PROFILES TO PREDICT BREAST CANCER OUTCOMES 有权
    基因表达谱预测乳腺癌的结果

    公开(公告)号：US20110145176A1

    公开(公告)日：2011-06-16

    申请号：US12995450

    申请日：2009-06-01

    申请人： Charles M. Perou ,  Joel S. Parker ,  James Stephen Marron ,  Andrew Nobel ,  Philip S. Bernard ,  Matthew Ellis ,  Elaine Mardis ,  Torsten O. Nielsen ,  Maggie Cheang

    发明人： Charles M. Perou ,  Joel S. Parker ,  James Stephen Marron ,  Andrew Nobel ,  Philip S. Bernard ,  Matthew Ellis ,  Elaine Mardis ,  Torsten O. Nielsen ,  Maggie Cheang

    IPC分类号： G06F15/18 ,  C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G06F19/20 ,  G06F19/24

    摘要： Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer. Methods of the invention further include means for evaluating gene expression profiles, including microarrays and quantitative polymerase chain reaction assays, as well as kits comprising reagents for practicing the methods of the invention.

    摘要翻译： 提供了分类和评估患有乳腺癌的受试者的预后的方法。 这些方法包括使用训练为基于乳腺癌内在亚型分层受试者的监督算法来预测乳腺癌亚型。 该预测模型基于表1中列出的内在基因的基因表达谱。该预测模型可用于准确预测诊断患有或怀疑患有乳腺癌的受试者的内在亚型。 还提供了用于预测诊断患有或疑似患有乳腺癌的受试者的治疗结果或反应的组合物和方法。 这些方法可用于指导或确定患有乳腺癌的受试者的治疗方案。 本发明的方法还包括用于评价基因表达谱（包括微阵列和定量聚合酶链反应测定）的方法，以及包含用于实施本发明方法的试剂的试剂盒。

    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
    8.
    发明授权
    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors 失效
    分类，诊断，分层和治疗癌症患者及其肿瘤的方法

    公开(公告)号：US07118853B2

    公开(公告)日：2006-10-10

    申请号：US09916849

    申请日：2001-07-26

    申请人： David Botstein ,  Patrick O. Brown ,  Charles M. Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan Matthijs van de Rijn

    发明人： David Botstein ,  Patrick O. Brown ,  Charles M. Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan Matthijs van de Rijn

    IPC分类号： G01N33/50 ,  G01N33/53 ,  G01N33/536 ,  C12Q1/68

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K16/18

    摘要： The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of breast cancer and for identification of therapies for breast cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

    摘要翻译： 本发明提供用于诊断和治疗乳腺癌的各种试剂。 本发明利用cDNA微阵列技术鉴定了大量肿瘤样本的表达谱与细胞角蛋白5和细胞角蛋白17（正常乳腺泌乳腺基底细胞的标记）相关的基因。 本发明表明，表达细胞角蛋白5/6和/或17的肿瘤总体上相对于肿瘤的预后差。 本发明提供了基础标记基因及其表达产物和这些基因用于乳腺癌诊断和鉴定乳腺癌疗法的用途。 特别地，本发明提供了包括钙粘蛋白3，基质金属蛋白酶14和钙粘蛋白EGF LAG七通G型受体2的基础标记基因。本发明提供了由这些基因表达的多肽的抗体及其使用方法。

    Compositions for the diagnosis and treatment of Chediak-Higashi syndrome
    9.
    发明授权
    Compositions for the diagnosis and treatment of Chediak-Higashi syndrome 失效
    Chediak-Higashi综合征的诊断和治疗组合

    公开(公告)号：US06310182B1

    公开(公告)日：2001-10-30

    申请号：US09396540

    申请日：1999-09-14

    申请人： Jerry Kaplan ,  Charles M. Perou ,  Karen J. Moore

    发明人： Jerry Kaplan ,  Charles M. Perou ,  Karen J. Moore

    IPC分类号： C07K14435

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the differentiation and/or function of intracellular vesicles. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian bg gene, a gene that, when mutated, is responsible or the human Chediak-Higashi syndrome.

    摘要翻译： 本发明涉及鉴定参与细胞内小泡分化和/或功能的由此类核酸分子或其简并变体编码的新的核酸分子和蛋白质。 本发明的核酸分子代表与哺乳动物bg基因相对应的基因，突变后负责的基因或人Chediak-Higashi综合征。