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公开(公告)号：US07432299B2
公开(公告)日：2008-10-07
申请号：US10726878
申请日：2003-12-02
申请人： Charles Price Taylor, Jr. , Andrew John Thorpe , Pieter Hadewijn Van Der Graaf , Christopher Peter Wayman , David Juergen Wustrow
发明人： Charles Price Taylor, Jr. , Andrew John Thorpe , Pieter Hadewijn Van Der Graaf , Christopher Peter Wayman , David Juergen Wustrow
IPC分类号： A61K31/195
CPC分类号： A61K31/662 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06
摘要： Use of an alpha-2-delta ligand, or a pharmaceutically acceptable derivative thereof, for the manufacture of a medicament for the treatment of premature ejaculation.
摘要翻译： α-2-δ配体或其药学上可接受的衍生物在制备用于治疗早泄的药物中的用途。
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公开(公告)号：US07381747B2
公开(公告)日：2008-06-03
申请号：US11470730
申请日：2006-09-07
IPC分类号： A01N37/12
CPC分类号： A61K31/662 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; andR2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及一种治疗选自OCD，广场恐怖症，恐慌症，恐惧症，社交恐惧症，PTSD，不宁腿综合症，经前焦虑症，热潮红，纤维肌痛等症状的病症的方法。 式1或其药学上可接受的盐，其中：R 1是氢，1至6个碳原子的直链或支链烷基或苯基; R 2是具有4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个的烷氧基 碳原子， - 烷基环烷基， - 烷基烷氧基， - 烷基OH - - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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公开(公告)号：US07164034B2
公开(公告)日：2007-01-16
申请号：US10734917
申请日：2003-12-12
IPC分类号： C07C10/00
CPC分类号： A61K31/662 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/401 , A61K31/4015 , A61K31/41 , A61K31/4245 , A61K31/433 , A61K45/06 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.
摘要翻译： 本发明涉及一种治疗选自OCD，广场恐怖症，恐慌症，恐惧症，社交恐惧症，PTSD，不宁腿综合症，经前焦虑症，热潮红，纤维肌痛等症状的病症的方法。 式1或其药学上可接受的盐，其中：R 1是氢，1至6个碳原子的直链或支链烷基或苯基; R 2是具有4至8个碳原子的直链或支链烷基，2至8个碳原子的直链或支链烯基，3至7个碳原子的环烷基，1至6个的烷氧基 碳原子， - 烷基环烷基， - 烷基烷氧基， - 烷基OH - - 烷基苯基， - 烷基苯氧基或 - 取代的苯基。 本发明还涉及通过给予化合物（3S，5R）-3-氨基甲基-5-甲基 - 辛酸来治疗上述病症的方法。
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4.发明授权Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds 失效使用N-（2,6-二取代芳族）-N'-吡啶基脲和其他抗惊厥化合物治疗神经变性疾病和病症的方法
公开(公告)号：US6133299A
公开(公告)日：2000-10-17
申请号：US23016
申请日：1993-02-25
IPC分类号： A61K31/165 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/53 , A61K31/55
CPC分类号： A61K31/7004 , A61K31/165 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/53 , A61K31/55
摘要： The instant invention is novel uses of known N-(2,6-disubstituted phenyl)-N'-3- and 4-pyridinyl ureas and pharmaceutically acceptable acid addition salts thereof. Such compounds as N-(2-chloro-6-methylphenyl)-N'-4-pyridinyl urea monohydrochloride or N-(2,3-dichlorophenyl)-N'-4-pyridinyl urea are used for treating neurodegenerative disorders, perinatal asphyxia, Alzheimer's disease, Huntington's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. The instant invention is similar novel uses of known anticonvulsant compounds as ralitoline, phenytoin, lamotrigine, tetrodotoxin, lidocaine, and carbamazepine.
摘要翻译： 本发明是已知的N-（2,6-二取代苯基）-N'-3-和4-吡啶基脲及其药学上可接受的酸加成盐的新用途。 此类化合物如N-（2-氯-6-甲基苯基）-N'-4-吡啶基脲单盐酸盐或N-（2,3-二氯苯基）-N'-4-吡啶基脲用于治疗神经变性疾病，围产期窒息 ，阿尔茨海默氏病，亨廷顿病，帕金森病和肌萎缩性侧索硬化。 本发明是已知的抗惊厥化合物的类似新颖用途，如雷洛芬，苯妥英，拉莫三嗪，河豚毒素，利多卡因和卡马西平。
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公开(公告)号：US6127418A
公开(公告)日：2000-10-03
申请号：US284710
申请日：1999-04-19
申请人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William P. Watson
发明人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William P. Watson
IPC分类号： A61K31/195 , A61K31/197 , A61K31/40 , A61K31/405 , A61K31/42 , A61K31/54 , A61K31/60
CPC分类号： A61K31/42 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/405 , A61K31/54 , A61K31/60
摘要： The present invention is directed to a method for preventing visceral and gastrointestinal damage such as gastric ulcers by administering a gamma-aminobutyric acid (GABA) analog and for treating gastrointestinal diseases such as inflammatory bowel disorders (IBD), functional bowel disorders (FBD) including dyspepsia and other visceral pain.
摘要翻译： PCT No.PCT / US98 / 17082 Sec。 371 1999年4月19日第 102（e）1999年4月19日PCT PCT 1998年8月18日PCT公布。 WO99 / 08671 PCT出版物 日期1999年2月25日本发明涉及一种通过施用γ-氨基丁酸（GABA）类似物和用于治疗诸如炎性肠病（IBD），功能性肠胃肠疾病的胃内溃疡等内脏和胃肠道损伤的方法 疾病（FBD）包括消化不良和其他内脏痛。
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公开(公告)号：US06426368B2
公开(公告)日：2002-07-30
申请号：US09804742
申请日：2001-03-13
申请人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William Patrick Watson
发明人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William Patrick Watson
IPC分类号： A61K31195
CPC分类号： A61K31/42 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/405 , A61K31/54 , A61K31/60 , A61K45/06 , A61K31/19 , A61K2300/00
摘要： GABA analogs are useful to prevent and treat gastrointestinal damage and ethanol withdrawal syndrome. Preferred treatments employ gabapentin or pregabalin.
摘要翻译： GABA类似物可用于预防和治疗胃肠损伤和乙醇戒断综合征。 优选的疗法使用加巴喷丁或普瑞巴林。
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公开(公告)号：US06242488B1
公开(公告)日：2001-06-05
申请号：US09567191
申请日：2000-05-09
申请人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William Patrick Watson
发明人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William Patrick Watson
IPC分类号： A61K31195
CPC分类号： A61K31/42 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/405 , A61K31/54 , A61K31/60 , A61K45/06 , A61K31/19 , A61K2300/00
摘要： GABA analogs are useful to prevent and treat gastrointestinal damage and ethanol withdrawal syndrome. Preferred treatments employ gabapentin or pregabalin.
摘要翻译： GABA类似物可用于预防和治疗胃肠道损伤和乙醇戒断综合征。 优选的疗法使用加巴喷丁或普瑞巴林。
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8.发明授权Method of treating neurodegenerative diseases using an AMPA excitatory amino and an uricosuric agent 失效使用AMPA兴奋性氨基和尿酸润滑剂治疗神经变性疾病的方法
公开(公告)号：US5767119A
公开(公告)日：1998-06-16
申请号：US775637
申请日：1996-12-31
IPC分类号： A61K31/19 , A61K31/47 , A61K31/495 , A61K31/675 , A61K45/00 , A61K45/06 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/28 , A61P43/00 , A61K31/195 , A61K31/50
CPC分类号： A61K31/675 , A61K31/47 , A61K31/495 , A61K45/06
摘要： The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.
摘要翻译： 本发明是具有尿酸润滑剂如丙磺舒等的组合物和可用于治疗有利于用兴奋性氨基酸拮抗剂治疗影响的疾病的兴奋性氨基酸拮抗剂的药物组合物。
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9.发明授权公开(公告)号：US06887902B2
公开(公告)日：2005-05-03
申请号：US09924656
申请日：2001-08-08
IPC分类号： A61K31/195 , A61K31/197 , A01N37/12
CPC分类号： A61K31/195 , A61K31/197
摘要： GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases.
摘要翻译： GABA类似物如加巴喷丁和普瑞巴林可用于预防和治疗炎性疾病。
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10.发明授权Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases 有权GABA类似物如加巴喷丁在制备用于治疗炎性疾病的药物中的用途公开(公告)号：US06329429B1
公开(公告)日：2001-12-11
申请号：US09403867
申请日：1999-10-25
IPC分类号： A01N3712
CPC分类号： A61K31/195 , A61K31/197
摘要： GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases.
摘要翻译： GABA类似物如加巴喷丁和普瑞巴林可用于预防和治疗炎性疾病。
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