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公开(公告)号：US07291619B2
公开(公告)日：2007-11-06
申请号：US10466121
申请日：2002-01-23
申请人： Christopher Kelly Biggers , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Larry Wayne Hertel , Vincent Mancuso , Michael John Martinelli , John Philip Mayer , Paul Leslie Ornstein , Timothy Ivo Richardson , Jikesh Arvind Shah , Qing Shi , Zhipei Wu , Chaoyu Xie
发明人： Christopher Kelly Biggers , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Larry Wayne Hertel , Vincent Mancuso , Michael John Martinelli , John Philip Mayer , Paul Leslie Ornstein , Timothy Ivo Richardson , Jikesh Arvind Shah , Qing Shi , Zhipei Wu , Chaoyu Xie
IPC分类号： A61K31/496 , C07D217/26 , C07D209/44
CPC分类号： A61K45/06 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to melanocortin receptor agonists of formula (I), which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式（I）的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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2.发明授权公开(公告)号：US07186715B2
公开(公告)日：2007-03-06
申请号：US10466248
申请日：2002-01-23
申请人： Karin Briner , Christopher William Doecke , Vincent Mancuso , Michael John Martinelli , Timothy Ivo Richardson , Roger Ryan Rothhaar , Qing Shi , Chaoyu Xie
发明人： Karin Briner , Christopher William Doecke , Vincent Mancuso , Michael John Martinelli , Timothy Ivo Richardson , Roger Ryan Rothhaar , Qing Shi , Chaoyu Xie
IPC分类号： A61K31/496 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： A61K45/06 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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3.发明授权公开(公告)号：US07442812B2
公开(公告)日：2008-10-28
申请号：US10552504
申请日：2004-04-08
IPC分类号： C07D311/78 , A01N43/16
CPC分类号： C07D311/80 , C07D311/94 , C07D493/04 , C07D495/04
摘要： The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor β agonists for treating Estrogen Receptor β mediated diseases such as benign prostatic hyperplasia.
摘要翻译： 本发明涉及用作治疗雌激素受体β介导的疾病例如良性前列腺增生的用于雌激素受体β激动剂的取代的苯并吡喃衍生物，立体异构体和其药学上可接受的盐。
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4.发明授权公开(公告)号：US08476300B2
公开(公告)日：2013-07-02
申请号：US13062272
申请日：2009-09-03
申请人： Jeffrey Alan Dodge , Timothy Ivo Richardson , Christian Alexander Clarke , Scott Alan Jones , Ronald Jay Hinklin , Conrad Wilson Hummel , George Sal Lewis
发明人： Jeffrey Alan Dodge , Timothy Ivo Richardson , Christian Alexander Clarke , Scott Alan Jones , Ronald Jay Hinklin , Conrad Wilson Hummel , George Sal Lewis
IPC分类号： A61K31/4453 , C07D211/06
CPC分类号： C07D333/08 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38
摘要： The present invention is directed to a compound of the formula (A): or a pharmaceutically acceptable salt thereof; and also to compounds of formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及式（A）的化合物或其药学上可接受的盐; 以及式（I）化合物或其药学上可接受的盐。
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5.发明申请公开(公告)号：US20110166182A1
公开(公告)日：2011-07-07
申请号：US13062272
申请日：2009-09-03
申请人： Jeffrey Alan Dodge , Timothy Ivo Richardson , Christian Alexander Clarke , Scott Alan Jones , Ronald Jay Hinklin , Conrad Wilson Hummel , George Sal Lewis
发明人： Jeffrey Alan Dodge , Timothy Ivo Richardson , Christian Alexander Clarke , Scott Alan Jones , Ronald Jay Hinklin , Conrad Wilson Hummel , George Sal Lewis
IPC分类号： A61K31/4535 , C07D409/12 , A61P19/02
CPC分类号： C07D333/08 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38
摘要： The present invention is directed to a compound of the formula (A): or a pharmaceutically acceptable salt thereof; and also to compounds of formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及式（A）的化合物或其药学上可接受的盐; 以及式（I）化合物或其药学上可接受的盐。
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6.发明授权公开(公告)号：US07279499B2
公开(公告)日：2007-10-09
申请号：US10549106
申请日：2004-04-08
IPC分类号： C07D311/76 , C07D311/94
CPC分类号： C07D311/94
摘要： The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof and processes for the preparation of the same. The compounds of the present invention are useful as Estrogen Receptor ? agonists. Such agonists are useful for the treating Estrogen Receptor ? mediated diseases such as prostate cancer or BPH.
摘要翻译： 本发明涉及取代的苯并吡喃衍生物，立体异构体及其药学上可接受的盐及其制备方法。 本发明的化合物可用作雌激素受体？ 激动剂。 这样的激动剂可用于治疗雌激素受体？ 介导的疾病如前列腺癌或BPH。
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7.发明授权公开(公告)号：US07842822B2
公开(公告)日：2010-11-30
申请号：US12533220
申请日：2009-07-31
IPC分类号： C07D409/00 , C07D311/78 , A61K31/38 , A61K31/35
CPC分类号： C07D311/80 , C07D311/94 , C07D493/04 , C07D495/04
摘要： The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor beta agonists for treating Estrogen Receptor beta mediated diseases such as benign prostatic hyperplasia.
摘要翻译： 本发明涉及用作治疗雌激素受体β介导的疾病例如良性前列腺增生的用于雌激素受体β激动剂的取代的苯并吡喃衍生物，立体异构体和其药学上可接受的盐。
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8.发明授权公开(公告)号：US07217734B2
公开(公告)日：2007-05-15
申请号：US10493092
申请日：2002-11-07
申请人： Jeffrey Alan Dodge , Venkatesh Krishnan , Charles Willis Lugar, III , Blake Lee Neubauer , Bryan Hurst Norman , Lance Allen Pfeifer , Timothy Ivo Richardson
发明人： Jeffrey Alan Dodge , Venkatesh Krishnan , Charles Willis Lugar, III , Blake Lee Neubauer , Bryan Hurst Norman , Lance Allen Pfeifer , Timothy Ivo Richardson
IPC分类号： A61K31/35
CPC分类号： C07D311/80 , C07D311/94
摘要： The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof and processes for the preparation of the same. The compounds of the present invention are useful as Estrogen Receptor β agonists. Such agonists are useful for the treating Estrogen Receptor β mediated diseases such as prostate cancer.
摘要翻译： 本发明涉及取代的苯并吡喃衍生物，立体异构体及其药学上可接受的盐及其制备方法。 本发明的化合物可用作雌激素受体β激动剂。 这样的激动剂可用于治疗雌激素受体β介导的疾病如前列腺癌。
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9.发明申请公开(公告)号：US20090298925A1
公开(公告)日：2009-12-03
申请号：US12533220
申请日：2009-07-31
IPC分类号： A61K31/352 , C07D495/04 , C07D311/94 , A61K31/381 , A61P35/00
CPC分类号： C07D311/80 , C07D311/94 , C07D493/04 , C07D495/04
摘要： The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor beta agonists for treating Estrogen Receptor beta mediated diseases such as benign prostatic hyperplasia.
摘要翻译： 本发明涉及用作治疗雌激素受体β介导的疾病例如良性前列腺增生的用于雌激素受体β激动剂的取代的苯并吡喃衍生物，立体异构体和其药学上可接受的盐。
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公开(公告)号：US20090069400A1
公开(公告)日：2009-03-12
申请号：US12160460
申请日：2007-01-17
申请人： Thomas John Bleisch , Christian Alexander Clarke , Jeffrey Alan Dodge , Scott Alan Jones , Jose Eduardo Lopez , Charles Willis Lugar, III , Brian Stephen Muehl , Timothy Ivo Richardson , Ying Kwong Yee , Kuo-Long Yu
发明人： Thomas John Bleisch , Christian Alexander Clarke , Jeffrey Alan Dodge , Scott Alan Jones , Jose Eduardo Lopez , Charles Willis Lugar, III , Brian Stephen Muehl , Timothy Ivo Richardson , Ying Kwong Yee , Kuo-Long Yu
IPC分类号： A61K31/404 , C07D209/14
CPC分类号： C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/24 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I), wherein n is 1 or 2, and R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, their preparation, pharmaceutical compositions, and methods of use are disclosed.
摘要翻译： 其中n为1或2，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义的式（I）化合物，其制备，药物组合物和使用方法公开。
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