公开(公告)号：US20230049760A1

公开(公告)日：2023-02-16

申请号：US17789598

申请日：2020-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： Jenna MCMAHON ,  Elvin Irsan KOOI ,  Liang WU ,  René Marcel DE JONG ,  Valmik Kanubhai VYAS ,  Peter Louis HOUSTON

IPC: C12N9/20 ,  C12P23/00 ,  C12Q1/44

Abstract: The present invention is related to a retinoid-producing host cell, particularly oleaginous yeast, modified such that the percentage of retinyl acetate based on the total retinoids produced by such host cell is increased during fermentation using triglyceride oils, like for example vegetable oil, as carbon source, wherein the activity of certain endogenous hydrolases or transferases involved in undesired conversions of retinol or retinol acetate is reduced or abolished. Particularly, such modified host cell might be useful in a biotechnological process for production of vitamin A.