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公开(公告)号：US20250161232A1
公开(公告)日：2025-05-22
申请号：US18838971
申请日：2023-02-21
Applicant: DSM IP Assets B.V.
Inventor： Linda HAENDEL , Peter Louis HOUSTON , Eileen JACKSON , Lise Anne KOHLER , Christine MENDROK-EDINGER , Fabiola PORTA , Pascal Christian SIEBER , Christos TSEKOU , Angela WILDERMANN
Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.
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公开(公告)号：US20230049760A1
公开(公告)日：2023-02-16
申请号：US17789598
申请日：2020-12-18
Applicant: DSM IP ASSETS B.V.
Inventor： Jenna MCMAHON , Elvin Irsan KOOI , Liang WU , René Marcel DE JONG , Valmik Kanubhai VYAS , Peter Louis HOUSTON
Abstract: The present invention is related to a retinoid-producing host cell, particularly oleaginous yeast, modified such that the percentage of retinyl acetate based on the total retinoids produced by such host cell is increased during fermentation using triglyceride oils, like for example vegetable oil, as carbon source, wherein the activity of certain endogenous hydrolases or transferases involved in undesired conversions of retinol or retinol acetate is reduced or abolished. Particularly, such modified host cell might be useful in a biotechnological process for production of vitamin A.
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公开(公告)号：US20220356503A1
公开(公告)日：2022-11-10
申请号：US17626946
申请日：2020-07-15
Applicant: DSM IP Assets B.V.
Inventor： Peter Louis HOUSTON , René Marcel DE JONG
Abstract: The present invention is related to a method for increasing the trans-specificity of a beta-carotene oxidase (BCO), particularly insect BCO, to be used in the production of vitamin A aldehyde (retinal) from conversion of beta-carotene, with at least about 75 to 100% of retinal in the trans-isoform.
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公开(公告)号：US20250134834A1
公开(公告)日：2025-05-01
申请号：US18838710
申请日：2023-02-21
Applicant: DSM IP Assets B.V.
Inventor： Linda HAENDEL , Peter Louis HOUSTON , Eileen JACKSON , Lise Anne KOHLER , Christine MENDROK-EDINGER , Fabiola PORTA , Pascal Christian SIEBER , Christos TSEKOU , Angela WILDERMANN
Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.
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公开(公告)号：US20250002873A1
公开(公告)日：2025-01-02
申请号：US18700931
申请日：2022-10-19
Applicant: DSM IP ASSETS B.V.
Inventor： Valmik Kanubhai VYAS , Peter Louis HOUSTON , Jenna McMAHON , René Marcel DE JONG
Abstract: The present invention is related to bio-production of retinoids with improved purity profile, particularly bio-retinoids with a high percentage of retinyl acetate, wherein the flux towards retinol is increased and wherein the percentage of unwanted by-products such as dihydroretinoids or retinal is minimized to a range of below 10% by expressing retinol dehydrogenase (EC 1.1.1.105, RDH22) derived from Yarrowia lipolytica (Candida lipolytica) or Wickerhamomyces anomalus (Hanensula anomala).
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Patent Agency Ranking
公开(公告)号：US20240018564A1
公开(公告)日：2024-01-18
申请号：US18251167
申请日：2021-11-01
Applicant: DSM IP ASSETS B.V.
Inventor： Peter Louis HOUSTON , Valmik Kanubhai VYAS
CPC classification number: C12P23/00 , C12N9/20 , C12Y301/01003 , C12Y203/01084 , C12N9/1029
Abstract: The present invention is related to a fermentative production of retinoids, including retinol or retinyl acetate, comprising cultivation of a retinoid-producing host cell, such as fungal host cell, particularly oleaginous host such as e.g. Yarrowia, in a two-phase culture system in the presence of vegetable oil as second phase. The retinoids present in the vegetable oil can be used without further isolation or purification steps as active ingredients in the food, feed, pharma or cosmetic industry.
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公开(公告)号：US20220064607A1
公开(公告)日：2022-03-03
申请号：US17419079
申请日：2019-12-30
Applicant: DSM IP Assets B.V.
Inventor： Peter Louis HOUSTON , René Marcel DE JONG , Valmik Kanubhai VYAS , René VERWAAL , Jenna McMAHON , Anna SYMBOR-NAGRABSKA
Abstract: The present invention is related to production of retinyl acetate generated via enzymatic conversion of retinol, said process including the use of modified enzymes with improved activity.
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公开(公告)号：US20250152493A1
公开(公告)日：2025-05-15
申请号：US18838904
申请日：2023-02-21
Applicant: DSM IP Assets B.V.
Inventor： Linda HAENDEL , Peter Louis HOUSTON , Eileen JACKSON , Lise Anne KOHLER , Christine MENDROK-EDINGER , Fabiola PORTA , Pascal Christian SIEBER , Christos TSEKOU , Angela WILDERMANN
IPC: A61K8/67
Abstract: The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.
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公开(公告)号：US20250040538A1
公开(公告)日：2025-02-06
申请号：US18715377
申请日：2022-12-05
Applicant: DSM IP ASSETS B.V.
Inventor： Christine MENDROK-EDINGER , Eileen JACKSON , Angela WILDERMANN , Peter Louis HOUSTON
Abstract: The present invention relates to novel compositions comprising mixtures of cis and trans isomers of retinol, particularly with a cis/trans ratio of less than 1:100, as well as the use of said compositions for preservation.
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公开(公告)号：US20240279706A1
公开(公告)日：2024-08-22
申请号：US18292227
申请日：2021-07-27
Applicant: DSM IP ASSETS B.V.
Inventor： Peter Louis HOUSTON , Valmik Kanubhai VYAS , Anna SYMBOR-NAGRABSKA , Reed Chadbourne DOTEN , Christopher Mark FARRELL , Ethan LAM
CPC classification number: C12P23/00 , C12N1/16 , C12N9/1029
Abstract: The present invention is related to a novel process for production of retinyl acetate in a host cell, particularly oleaginous yeast such as e.g. Yarrowia, wherein the product purity could be increased with reduction of unwanted side-products. Particularly, the novel process comprises fermentation in the presence of ethanol, such as e.g. in a fed-batch fermentation process. Such process is especially useful in a biotechnological process for production of vitamin A.
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