公开(公告)号：US20150152450A1

公开(公告)日：2015-06-04

申请号：US14566458

申请日：2014-12-10

Applicant: DSM IP ASSETS B.V.

Inventor： Kirk E. APT ,  Leslie RICHTER ,  David SIMPSON ,  Ross ZIRKLE

IPC: C12P7/64 ,  C12N9/02 ,  C12N9/88

CPC classification number: C12N15/52 ,  A61K38/00 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/88 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472 ,  C12Y101/01 ,  C12Y103/01 ,  C12Y203/01039 ,  C12Y203/01041 ,  C12Y402/01 ,  C12Y402/01059 ,  Y02P20/52

Abstract: The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.

Abstract translation: 本发明涉及涉及PUFA生产的分离的核酸分子和多烯突变多不饱和脂肪酸（PUFA）合成酶，包括富含二十二碳六烯酸（DHA），二十碳五烯酸（EPA）或其组合的PUFA。 本发明涉及包含核酸分子，核酸分子编码的多肽，包含核酸分子或多肽的组合物及其制备和用途的载体和宿主细胞。