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公开(公告)号：US20150064782A1
公开(公告)日：2015-03-05
申请号：US14390378
申请日：2013-04-02
申请人： LS9, INC.
发明人： Derek L. Greenfield , Andreas W. Schirmer , Elizabeth J. Clarke , Eli S. Groban , Bernardo M. Da Costa , Zhihao Hu
CPC分类号： C12N15/70 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/1288 , C12N9/88 , C12N9/90 , C12N9/93 , C12P7/04 , C12P7/6409 , C12P7/6436 , C12Y101/011 , C12Y103/01009 , C12Y103/0101 , C12Y203/01039 , C12Y203/01041 , C12Y203/01179 , C12Y203/0118 , C12Y207/08007 , C12Y402/01059 , C12Y503/03014 , C12Y604/01002
摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
摘要翻译： 本发明涉及组合物和方法，包括多核苷酸序列，氨基酸序列，重组宿主细胞和重组宿主细胞培养物，其工程改造以产生脂肪酸衍生物组合物，其包含脂肪酸，脂肪醇，脂肪醛，脂肪酸酯，烷烃，末端烯烃，内部 烯烃或酮。 脂肪酸衍生物组合物在细胞外产生比相应的野生型或非工程化宿主细胞更高的滴度，产量或生产力。
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公开(公告)号：US20140024872A1
公开(公告)日：2014-01-23
申请号：US13940861
申请日：2013-07-12
申请人： Calysta Energy, LLC
发明人： Joshua Silverman , Sol M. Resnick , Michael Mendez
IPC分类号： C10G3/00
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
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公开(公告)号：US20170088841A1
公开(公告)日：2017-03-30
申请号：US15371410
申请日：2016-12-07
申请人： DSM IP Assets B.V.
发明人： Kirk E. APT , Leslie Richter , David Simpson , Ross Zirkle
CPC分类号： C12N15/52 , A61K38/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y101/01 , C12Y103/01 , C12Y203/01039 , C12Y203/01041 , C12Y402/01 , C12Y402/01059 , Y02P20/52
摘要： The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
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公开(公告)号：US20160289782A1
公开(公告)日：2016-10-06
申请号：US15187509
申请日：2016-06-20
申请人： Calysta, Inc.
发明人： Joshua A. Silverman , Sol M. Resnick , Michael Mendez , Renee M. Saville , Sungwon Lee , Luan Nguyen
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
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公开(公告)号：US20160289714A1
公开(公告)日：2016-10-06
申请号：US15187492
申请日：2016-06-20
申请人： Calysta, Inc.
发明人： Joshua A. Silverman , Sol M. Resnick , Michael Mendez , Renee M. Saville , Sungwon Lee , Luan Nguyen
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
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6.发明申请POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 有权聚氨酯脂肪酸合成酶核酸分子和多肽，组合物及其制备方法及用途公开(公告)号：US20150152450A1
公开(公告)日：2015-06-04
申请号：US14566458
申请日：2014-12-10
申请人： DSM IP ASSETS B.V.
发明人： Kirk E. APT , Leslie RICHTER , David SIMPSON , Ross ZIRKLE
CPC分类号： C12N15/52 , A61K38/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y101/01 , C12Y103/01 , C12Y203/01039 , C12Y203/01041 , C12Y402/01 , C12Y402/01059 , Y02P20/52
摘要： The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
摘要翻译： 本发明涉及涉及PUFA生产的分离的核酸分子和多烯突变多不饱和脂肪酸（PUFA）合成酶，包括富含二十二碳六烯酸（DHA），二十碳五烯酸（EPA）或其组合的PUFA。 本发明涉及包含核酸分子，核酸分子编码的多肽，包含核酸分子或多肽的组合物及其制备和用途的载体和宿主细胞。
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7.发明申请Polyunsaturated Fatty Acid Synthase Nucleic Acid Molecules and Polypeptides, Compositions, and Methods of Making and Uses Thereof 有权多不饱和脂肪酸合成酶核酸分子和多肽，组合物及其制备和使用方法公开(公告)号：US20100266564A1
公开(公告)日：2010-10-21
申请号：US12727851
申请日：2010-03-19
申请人： Kirk E. Apt , Leslie Richter , David Simpson , Ross Zirkle
发明人： Kirk E. Apt , Leslie Richter , David Simpson , Ross Zirkle
IPC分类号： C12N15/52 , C12N15/63 , C12N5/10 , C12N1/00 , C12P7/64 , C12N9/00 , A61K38/43 , A61K48/00 , A61P3/00
CPC分类号： C12N15/52 , A61K38/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y101/01 , C12Y103/01 , C12Y203/01039 , C12Y203/01041 , C12Y402/01 , C12Y402/01059 , Y02P20/52
摘要： The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
摘要翻译： 本发明涉及涉及PUFA生产的分离的核酸分子和多烯突变多不饱和脂肪酸（PUFA）合成酶，包括富含二十二碳六烯酸（DHA），二十碳五烯酸（EPA）或其组合的PUFA。 本发明涉及包含核酸分子，核酸分子编码的多肽，包含核酸分子或多肽的组合物及其制备和用途的载体和宿主细胞。
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公开(公告)号：US09970032B2
公开(公告)日：2018-05-15
申请号：US14886983
申请日：2015-10-19
申请人： Calysta, Inc.
IPC分类号： C10L1/02 , C10L1/04 , C12P7/64 , C12N15/74 , C12P5/00 , C10G3/00 , C12N9/16 , C12N9/00 , C12N1/16 , C12N1/20 , C12N9/10 , C10G47/00 , C12N15/52 , C12R1/01
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
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公开(公告)号：US20180010137A1
公开(公告)日：2018-01-11
申请号：US15650285
申请日：2017-07-14
发明人： Derek L. GREENFIELD , Andreas W. Schirmer , Elizabeth J. CLARKE , Eli S. GROBAN , Bernardo M. Da Costa , Zhihao Hu , Kevin Holden , Noah Helman
IPC分类号： C12N15/70 , C12P7/64 , C12P7/04 , C12N9/02 , C12N9/90 , C12N9/88 , C12N9/12 , C12N9/10 , C12N9/04 , C12N9/00
CPC分类号： C12N15/70 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/1288 , C12N9/88 , C12N9/90 , C12N9/93 , C12P7/04 , C12P7/6409 , C12P7/6436 , C12Y101/011 , C12Y103/01009 , C12Y103/0101 , C12Y203/01039 , C12Y203/01041 , C12Y203/01179 , C12Y203/0118 , C12Y207/08007 , C12Y402/01059 , C12Y503/03014 , C12Y604/01002
摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
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公开(公告)号：US20150218508A1
公开(公告)日：2015-08-06
申请号：US14670740
申请日：2015-03-27
申请人： Calysta, Inc.
发明人： Joshua A. Silverman , Sol M. Resnick , Michael Mendez , Renee M. Saville , Sungwon Lee , Luan Nguyen
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
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