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公开(公告)号：US11905542B2
公开(公告)日：2024-02-20
申请号：US16648872
申请日：2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor： Nathalie Balch , Paul Blomquist , Reed Doten , Peter Houston , Ethan Lam , Jenna McMahon , Joshua Trueheart , Celine Viarouge
IPC: C12P23/00
CPC classification number: C12P23/00
Abstract: The present invention is related to a novel enzymatic process for production of retinyl esters, such as in particular retinyl long chain esters, via conversion of retinol, which process includes the use of enzymes having acyltransferase activity. Said process might be used for biotechnological production of vitamin A.
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Patent Agency Ranking
公开(公告)号：US20140234928A1
公开(公告)日：2014-08-21
申请号：US14183268
申请日：2014-02-18
Applicant: DSM IP ASSETS B.V.
Inventor： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart , Reed Doten , Maria Mayorga , Joshua Griffin Dunn , Dan Dueppen
IPC: C12P23/00
Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds.
Abstract translation: 本发明提供用于生产工程化含油酵母或表达视黄醛化合物的真菌的系统。
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公开(公告)号：US12252724B2
公开(公告)日：2025-03-18
申请号：US18161236
申请日：2023-01-30
Applicant: DSM IP ASSETS B.V.
Inventor： Nathalie Balch , Paul Blomquist , Reed Doten , Peter Houston , Ethan Lam , Jenna McMahon , Joshua Trueheart , Celine Viarouge
Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.
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公开(公告)号：US12049658B2
公开(公告)日：2024-07-30
申请号：US16648879
申请日：2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor： Nathalie Balch , Paul Blomquist , Reed Doten , Peter Houston , Ethan Lam , Jenna Mcmahon , Joshua Trueheart , Celine Viarouge , René Marcel De Jong
IPC: C12P23/00
CPC classification number: C12P23/00
Abstract: The present invention is related to production of retinyl esters, such as in particular retinyl acetate, an important building block for production of vitamin A. The retinyl esters might be generated via enzymatic conversion of retinol which process includes the use of enzymes with acetyl-transferase (ATF) activity, thus acetylating retinol into retinol/retinyl acetate. Said process is particularly useful for biotechnological production of vitamin A.
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公开(公告)号：US11578344B2
公开(公告)日：2023-02-14
申请号：US16647730
申请日：2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor： Nathalie Balch , Paul Blomquist , Reed Doten , Peter Houston , Ethan Lam , Jenna McMahon , Joshua Trueheart , Celine Viarouge
Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.
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公开(公告)号：US09297031B2
公开(公告)日：2016-03-29
申请号：US14183268
申请日：2014-02-18
Applicant: DSM IP ASSETS B.V.
Inventor： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart , Reed Doten , Maria Mayorga , Joshua Griffin Dunn , Dan Dueppen
Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds.
Abstract translation: 本发明提供用于生产工程化含油酵母或表达视黄醛化合物的真菌的系统。
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