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公开(公告)号：US20060079547A1
公开(公告)日：2006-04-13
申请号：US10960769
申请日：2004-10-07
申请人： Dale Dhanoa , Oren Becker , Silvia Noiman , Laurence Wu , Mercedes Lobera , Pradyumna Mohanty , Yael Marantz , Boaz Inbal , Sharon Shacham , Dongli Chen
发明人： Dale Dhanoa , Oren Becker , Silvia Noiman , Laurence Wu , Mercedes Lobera , Pradyumna Mohanty , Yael Marantz , Boaz Inbal , Sharon Shacham , Dongli Chen
IPC分类号： A61K31/4743 , C07D498/02
CPC分类号： C07D495/04
摘要： The invention relates to 5-HT4 receptor agonists and partial agonists. Novel thienopyridinone compounds and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT4 receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, Parkinson's disease, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, and nonulcer dyspepsia. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
摘要翻译： 本发明涉及5-HT 4受体激动剂和部分激动剂。 公开了新的噻吩并吡啶酮化合物及其用于治疗由5-HT 4受体直接或间接介导的疾病的合成及其用途。 这些病症包括阿尔茨海默氏病，认知障碍，肠易激综合征，帕金森病，恶心，呕吐，呕吐，运动失调，胃食管反流病和非溃疡性消化不良。 还包括制备方法和新型中间体及其药物盐。
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公开(公告)号：US20060084805A1
公开(公告)日：2006-04-20
申请号：US11269042
申请日：2005-11-08
申请人： Dale Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
发明人： Dale Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
IPC分类号： C07D498/02
CPC分类号： C07D495/04
摘要： The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
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公开(公告)号：US20050256153A1
公开(公告)日：2005-11-17
申请号：US10955434
申请日：2004-09-30
申请人： Dale Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
发明人： Dale Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
IPC分类号： A61K31/4743 , C07D495/04 , C07D498/02
CPC分类号： C07D495/04
摘要： The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
摘要翻译： 本发明涉及5-HT受体激动剂和部分激动剂。 公开了由式I表示的新型噻吩并吡啶酮化合物及其用于治疗由5-HT受体直接或间接介导的疾病的合成和用途。 这些病症包括阿尔茨海默病，认知障碍，肠易激综合征，恶心，呕吐，呕吐，运动失调，胃食管反流病，非溃疡性消化不良，抑郁症，焦虑症，尿失禁，偏头痛，心律失常，心房颤动，缺血性卒中，胃炎，胃排空障碍 ，喂食障碍，胃肠道疾病，便秘，勃起功能障碍和呼吸抑制。 还包括制备方法和新型中间体及其药物盐。
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公开(公告)号：US20060234998A1
公开(公告)日：2006-10-19
申请号：US11271019
申请日：2005-11-10
申请人： Dale Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
发明人： Dale Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
IPC分类号： A61K31/4743 , A61K31/55 , A61K31/445 , A61K31/473 , A61K31/454 , A61K31/407
CPC分类号： A61K45/06 , A61K31/4365 , A61K31/439 , A61K31/50 , A61K31/55 , A61K2300/00
摘要： The invention generally relates to thienopyridinone 5-HT4 receptor modulators, and in particular the use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with serotonin action, such as in treating Alzheimer's disease, cognition disorders, depression, and anxiety.
摘要翻译： 本发明一般涉及噻吩并吡啶酮5-HT 4受体调节剂，特别是这些化合物及其药物组合物的用途，例如用于治疗，调节和/或预防与5-羟色胺相关的生理条件 行为，例如治疗阿尔茨海默病，认知障碍，抑郁和焦虑。
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公开(公告)号：US07982040B2
公开(公告)日：2011-07-19
申请号：US12343818
申请日：2008-12-24
申请人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
发明人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
IPC分类号： C07D221/02 , C07D515/02
CPC分类号： C07D495/04
摘要： The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
摘要翻译： 本发明涉及5-HT受体激动剂和部分激动剂。 公开了由式I表示的新型噻吩并吡啶酮化合物及其用于治疗由5-HT受体直接或间接介导的疾病的合成和用途。 这些病症包括阿尔茨海默病，认知障碍，肠易激综合征，恶心，呕吐，呕吐，运动失调，胃食管反流病，非溃疡性消化不良，抑郁症，焦虑症，尿失禁，偏头痛，心律失常，心房颤动，缺血性卒中，胃炎，胃排空障碍 ，喂食障碍，胃肠道疾病，便秘，勃起功能障碍和呼吸抑制。 还包括制备方法和新型中间体及其药物盐。
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公开(公告)号：US20110195953A1
公开(公告)日：2011-08-11
申请号：US12570510
申请日：2009-09-30
申请人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
发明人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
IPC分类号： A61K31/55 , A61K31/4365 , A61P25/28
CPC分类号： A61K45/06 , A61K31/4365 , A61K31/439 , A61K31/50 , A61K31/55 , A61K2300/00
摘要： The invention generally relates to thienopyridinone 5-HT4 receptor modulators, and in particular the use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with serotonin action, such as in treating Alzheimer's disease, cognition disorders, depression, and anxiety.
摘要翻译： 本发明一般涉及噻吩并吡啶酮5-HT4受体调节剂，特别是这些化合物及其药物组合物的用途，例如用于治疗，调节和/或预防与5-羟色胺作用有关的生理条件，例如治疗阿尔茨海默病 ，认知障碍，抑郁和焦虑。
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公开(公告)号：US07598265B2
公开(公告)日：2009-10-06
申请号：US11271019
申请日：2005-11-10
申请人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
发明人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
IPC分类号： A61K31/44 , C07D513/02
CPC分类号： A61K45/06 , A61K31/4365 , A61K31/439 , A61K31/50 , A61K31/55 , A61K2300/00
摘要： The invention generally relates to thienopyridinone 5-HT4 receptor modulators, and in particular the use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with serotonin action, such as in treating Alzheimer's disease, cognition disorders, depression, and anxiety.
摘要翻译： 本发明一般涉及噻吩并吡啶酮5-HT4受体调节剂，特别是这些化合物及其药物组合物的用途，例如用于治疗，调节和/或预防与5-羟色胺作用有关的生理条件，例如治疗阿尔茨海默病 ，认知障碍，抑郁和焦虑。
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公开(公告)号：US20090163537A1
公开(公告)日：2009-06-25
申请号：US12343818
申请日：2008-12-24
申请人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
发明人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
IPC分类号： A61K31/4365 , C07D495/04
CPC分类号： C07D495/04
摘要： The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
摘要翻译： 本发明涉及5-HT受体激动剂和部分激动剂。 公开了由式I表示的新型噻吩并吡啶酮化合物及其用于治疗由5-HT受体直接或间接介导的疾病的合成和用途。 这些病症包括阿尔茨海默病，认知障碍，肠易激综合征，恶心，呕吐，呕吐，运动失调，胃食管反流病，非溃疡性消化不良，抑郁症，焦虑症，尿失禁，偏头痛，心律失常，心房颤动，缺血性卒中，胃炎，胃排空障碍 ，喂食障碍，胃肠道疾病，便秘，勃起功能障碍和呼吸抑制。 还包括制备方法和新型中间体及其药物盐。
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公开(公告)号：US07407966B2
公开(公告)日：2008-08-05
申请号：US10960769
申请日：2004-10-07
申请人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Laurence Wu , Mercedes Lobera , Pradyumna Mohanty , Yael Marantz , Boaz Inbal , Sharon Shacham , Dongli Chen
发明人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Laurence Wu , Mercedes Lobera , Pradyumna Mohanty , Yael Marantz , Boaz Inbal , Sharon Shacham , Dongli Chen
IPC分类号： A01N43/42 , C07D471/02
CPC分类号： C07D495/04
摘要： The invention relates to 5-HT4 receptor agonists and partial agonists. Thienopyridinone compounds and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT4 receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, Parkinson's disease, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, and nonulcer dyspepsia. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
摘要翻译： 本发明涉及5-HT 4受体激动剂和部分激动剂。 公开了噻吩并吡啶酮化合物及其用于治疗由5-HT 4受体直接或间接介导的疾病的合成及其用途。 这些病症包括阿尔茨海默氏病，认知障碍，肠易激综合征，帕金森病，恶心，呕吐，呕吐，运动失调，胃食管反流病和非溃疡性消化不良。 还包括制备方法和新型中间体及其药物盐。
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公开(公告)号：US07576211B2
公开(公告)日：2009-08-18
申请号：US11269042
申请日：2005-11-08
申请人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Dongli Chen , Yael Marantz , Sharon Shacham , Alexander Heifetz , Boaz Inbal , Shay Bar-Haim , Pradyumna Mohanty , Mercedes Lobera , Laurence Wu
发明人： Dale S. Dhanoa , Oren Becker , Silvia Noiman , Dongli Chen , Yael Marantz , Sharon Shacham , Alexander Heifetz , Boaz Inbal , Shay Bar-Haim , Pradyumna Mohanty , Mercedes Lobera , Laurence Wu
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
摘要翻译： 本发明涉及5-HT受体激动剂和部分激动剂。 公开了由式I表示的新型噻吩并吡啶酮化合物及其用于治疗由5-HT受体直接或间接介导的疾病的合成和用途。 这些病症包括阿尔茨海默病，认知障碍，肠易激综合征，恶心，呕吐，呕吐，运动失调，胃食管反流病，非溃疡性消化不良，抑郁症，焦虑症，尿失禁，偏头痛，心律失常，心房颤动，缺血性卒中，胃炎，胃排空障碍 ，喂食障碍，胃肠道疾病，便秘，勃起功能障碍和呼吸抑制。 还包括制备方法和新型中间体及其药物盐。
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