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公开(公告)号：US07202237B2
公开(公告)日：2007-04-10
申请号：US10848132
申请日：2004-05-19
IPC分类号： C07D401/12 , A61K31/55
CPC分类号： C07D401/02 , C07D401/12 , C07D403/12
摘要： The present invention relates to novel pyridylether derivatives which are cholinergic ligands at nicotinic Ach receptors. The compounds of the invention are useful for the treatment of conditions, disorders, or diseases involving the cholinergic system of the central nervous system, pain, inflammatory diseases, diseases caused by smooth muscle contractions and as assistance in the cessation of chemical substance abuse.
摘要翻译： 本发明涉及新颖的吡啶基醚衍生物，它们是烟碱型Ach受体的胆碱能配体。 本发明的化合物可用于治疗涉及中枢神经系统的胆碱能系统，疼痛，炎性疾病，由平滑肌收缩引起的疾病以及停止化学物质滥用的协助的疾病，病症或疾病。
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2.发明授权Azaring-ether derivatives and their use as nicotinic ACh receptor modulators 失效Azared-ether衍生物及其作为烟碱性ACh受体调节剂的用途公开(公告)号：US06756386B1
公开(公告)日：2004-06-29
申请号：US09550379
申请日：2000-04-14
IPC分类号： A61K314462
CPC分类号： C07D401/02 , C07D401/12 , C07D403/12
摘要： The present invention relates to novel pyridylether derivatives which are cholinergic ligands at nicotinic Ach receptors. The compounds of the invention are useful for the treatment of conditions, disorders, or diseases involving the cholinergic system of the central nervous system, pain, inflammatory diseases, diseases caused by smooth muscle contractions and as assistance in the cessation of chemical substance abuse.
摘要翻译： 本发明涉及新颖的吡啶基醚衍生物，它们是烟碱型Ach受体的胆碱能配体。 本发明的化合物可用于治疗涉及中枢神经系统的胆碱能系统，疼痛，炎性疾病，由平滑肌收缩引起的疾病以及停止化学物质滥用的协助的疾病，病症或疾病。
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公开(公告)号：US08236793B2
公开(公告)日：2012-08-07
申请号：US12633505
申请日：2009-12-08
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Daniel B Timmermann
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Daniel B Timmermann
IPC分类号： A61K31/55 , C07D243/10
CPC分类号： C07D471/08
摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE](/abs-image/US/2010/12/02/US20100305108A1/abs.jpg.150x150.jpg)
4.发明申请NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开新的1,4-二氮杂双环[3.2.2]壬基吡啶衍生物及其医疗用途公开(公告)号：US20100305108A1
公开(公告)日：2010-12-02
申请号：US12742595
申请日：2008-11-13
申请人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen , John Paul Redrobe , Jens Damsgaard Mikkelsen
发明人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen , John Paul Redrobe , Jens Damsgaard Mikkelsen
IPC分类号： A61K31/551 , C07D471/08 , A61P25/00 , A61P25/18 , A61P25/24 , A61P3/04 , A61P25/28 , A61P25/22 , A61P25/30 , A61P29/00
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基嘧啶衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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5.发明授权Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效烷基取代的哌啶衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07547788B2
公开(公告)日：2009-06-16
申请号：US11579060
申请日：2005-06-14
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Birgitte L. Eriksen
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Birgitte L. Eriksen
IPC分类号： C07D211/06 , C07D211/40 , A61K31/445
CPC分类号： C07D211/42 , C07D211/46 , C07D211/54 , C07D211/58
摘要： This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型烷基取代的哌啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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6.发明授权Substituted aryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors 失效取代的芳氧基烷基胺及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07973082B2
公开(公告)日：2011-07-05
申请号：US11658902
申请日：2005-08-24
申请人： Birgitte L. Eriksen , Dan Peters , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
发明人： Birgitte L. Eriksen , Dan Peters , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
IPC分类号： A61K31/135 , C07C11/00
CPC分类号： C07C217/44 , C07C217/46 , C07C2601/02
摘要： This invention relates to novel substituted aryloxy alkylamines useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型取代的芳氧基烷基胺。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE](/abs-image/US/2011/02/24/US20110046118A1/abs.jpg.150x150.jpg)
7.发明申请NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开新的1,4-二氮杂双环[3.2.2]壬基吡啶衍生物及其医疗用途公开(公告)号：US20110046118A1
公开(公告)日：2011-02-24
申请号：US12742590
申请日：2008-11-13
申请人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen , John Paul Redrobe , Jens Damsgaard Mikkelsen
发明人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen , John Paul Redrobe , Jens Damsgaard Mikkelsen
IPC分类号： A61K31/551 , C07D487/08 , A61P25/00 , A61P1/12 , A61P1/04 , A61P11/06 , A61P15/10 , A61P15/04 , A61P17/10 , A61P29/00
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo [3.2.2]nonyl pyrimidine derivatives of formula (I) and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及式（I）的新的1,4-二氮杂 - 双环[3.2.2]壬基嘧啶衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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8.发明申请ENANTIOPURE QUINUCLIDINYLOXY PYRIDAZINES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 审中-公开纯化喹啉吡啶吡啶并使用它作为NICOTINIC乙酰胆碱受体配体公开(公告)号：US20100227869A1
公开(公告)日：2010-09-09
申请号：US12160402
申请日：2007-02-13
申请人： Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring
发明人： Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring
IPC分类号： A61K31/501 , C07D403/12 , A61P25/00 , A61P29/00 , A61P1/00 , A61P9/12 , A61P15/00 , A61P17/00
CPC分类号： C07D453/02
摘要： This invention relates to novel enantiopure azabicyclo pyridazinyloxy derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新型对映纯氮氮杂双环哒嗪氧基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE](/abs-image/US/2010/08/26/US20100216780A1/abs.jpg.150x150.jpg)
9.发明申请NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE 有权新的1,4-二氮杂双环[3.2.2]壬基氧杂环丁烷衍生物及其医疗用途公开(公告)号：US20100216780A1
公开(公告)日：2010-08-26
申请号：US12297333
申请日：2007-05-29
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Timo Dyhring
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Timo Dyhring
IPC分类号： A61K31/551 , C07D471/08 , A61P25/00 , A61P25/28 , A61P25/24 , A61P25/18 , A61P25/22 , A61P29/00 , A61P17/10 , A61P11/06 , A61P1/00
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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![NOVEL1,4-DIAZA-BICYCLO[3.2.2]NONYL HETEROARYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS](/abs-image/US/2010/08/19/US20100210625A1/abs.jpg.150x150.jpg)
10.发明申请NOVEL1,4-DIAZA-BICYCLO[3.2.2]NONYL HETEROARYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 失效新的1,4-二氮杂双环[3.2.2]有用的非线性乙酰胆碱受体配体有用的非对映异构体衍生物公开(公告)号：US20100210625A1
公开(公告)日：2010-08-19
申请号：US12733168
申请日：2008-08-14
申请人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser
发明人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser
IPC分类号： A61K31/551 , C07D487/08 , A61P29/00 , A61P25/30 , A61P17/00 , A61P1/00 , A61P15/00 , A61P25/06 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/08
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基杂芳基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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