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    Methods and systems for intracranial neurostimulation and/or sensing
    1.
    发明申请
    Methods and systems for intracranial neurostimulation and/or sensing 审中-公开
    颅内神经刺激和/或感觉的方法和系统

    公开(公告)号：US20050075680A1

    公开(公告)日：2005-04-07

    申请号：US10891834

    申请日：2004-07-15

    申请人： David Lowry ,  Brad Fowler ,  Gene Thompson

    发明人： David Lowry ,  Brad Fowler ,  Gene Thompson

    IPC分类号： A61N1/05 ,  A61N1/18

    CPC分类号： A61N1/0539 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/375

    摘要： Methods and systems for intracranial neurostimulation and/or sensing are disclosed. An intracranial signal transmission system in accordance with an embodiment of the invention includes a generally electrically insulating support body having a head portion configured to be positioned at least proximate to an outer surface of a patient's skull, and a shaft portion configured to extend into an aperture in the patient's skull. The system can further include at least one electrical contact portion carried by the support body. The at least one electrical contact portion can be positioned to transfer electrical signals to, from, or both to and from the patient's brain via the aperture in the patient's skull.

    摘要翻译： 公开了用于颅内神经刺激和/或感测的方法和系统。 根据本发明的实施例的颅内信号传输系统包括大致电绝缘的支撑体，其具有头部部分，该头部构造成至少邻近患者头骨的外表面定位，以及轴部分，其构造成延伸到孔 在病人的头骨。 该系统还可以包括由支撑体承载的至少一个电接触部分。 所述至少一个电接触部分可以被定位成经由患者颅骨中的孔将电信号传送到患者的脑部，从患者的大脑或从患者的大脑传递。

    Methods and systems for intracranial neurostimulation and/or sensing
    2.
    发明授权
    Methods and systems for intracranial neurostimulation and/or sensing 有权
    颅内神经刺激和/或感觉的方法和系统

    公开(公告)号：US08718777B2

    公开(公告)日：2014-05-06

    申请号：US12509110

    申请日：2009-07-24

    申请人： David Warren Lowry ,  Brad Fowler ,  Gene Thompson

    发明人： David Warren Lowry ,  Brad Fowler ,  Gene Thompson

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0539 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/375

    摘要： Methods and systems for intracranial neurostimulation and/or sensing are disclosed. An intracranial signal transmission system in accordance with an embodiment of the invention includes a generally electrically insulating body having a head portion configured to be positioned at least proximate to an outer surface of a patient's skull, and a shaft portion configured to extend into an aperture in the patient's skull. The system can further include at least one electrical contact portion integrated with the support body. The at least one electrical contact portion can be positioned to transfer electrical signals to, from, or both to and from the patient's brain via an aperture in the patient's skull.

    摘要翻译： 公开了用于颅内神经刺激和/或感测的方法和系统。 根据本发明的实施例的颅内信号传输系统包括通常电绝缘的主体，其具有被配置为至少靠近患者颅骨的外表面定位的头部部分，以及被配置为延伸到患者颅骨的外表面中的轴部分 病人的头骨。 该系统还可以包括与支撑体一体化的至少一个电接触部分。 所述至少一个电接触部分可以被定位成经由患者颅骨中的孔将电信号传送到患者的大脑，从两者或从患者的大脑传递。

    METHODS AND SYSTEMS FOR INTRACRANIAL NEUROSTIMULATION AND/OR SENSING
    3.
    发明申请
    METHODS AND SYSTEMS FOR INTRACRANIAL NEUROSTIMULATION AND/OR SENSING 有权
    神经内分泌和/或感觉的方法和系统

    公开(公告)号：US20090292344A1

    公开(公告)日：2009-11-26

    申请号：US12509110

    申请日：2009-07-24

    申请人： David Warren Lowry ,  Brad Fowler ,  Gene Thompson

    发明人： David Warren Lowry ,  Brad Fowler ,  Gene Thompson

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0539 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/375

    摘要： Methods and systems for intracranial neurostimulation and/or sensing are disclosed. An intracranial signal transmission system in accordance with an embodiment of the invention includes a generally electrically insulating body having a head portion configured to be positioned at least proximate to an outer surface of a patient's skull, and a shaft portion configured to extend into an aperture in the patient's skull. The system can further include at least one electrical contact portion integrated with the support body. The at least one electrical contact portion can be positioned to transfer electrical signals to, from, or both to and from the patient's brain via an aperture in the patient's skull.

    摘要翻译： 公开了用于颅内神经刺激和/或感测的方法和系统。 根据本发明的实施例的颅内信号传输系统包括通常电绝缘的主体，其具有被配置为至少靠近患者颅骨的外表面定位的头部部分，以及被配置为延伸到患者颅骨的外表面中的轴部分 病人的头骨。 该系统还可以包括与支撑体一体化的至少一个电接触部分。 所述至少一个电接触部分可以被定位成经由患者颅骨中的孔将电信号传送到患者的大脑，从两者或从患者的大脑传递。

    SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY
    4.
    发明申请
    SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 有权
    用于增强或影响神经刺激效能和/或效率的系统和方法

    公开(公告)号：US20120041498A1

    公开(公告)日：2012-02-16

    申请号：US13179133

    申请日：2011-07-08

    申请人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    发明人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    IPC分类号： A61N1/36

    CPC分类号： H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

    摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

    摘要翻译： 公开了用于增强或影响神经刺激效率和/或功效的系统和方法。 在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。 第一和第二时域可以是顺序的，同时的或嵌套的。 刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。 刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。 在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发​​频率以及规则和/或变化的腹内刺激参数的突发模式。 在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

    Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
    5.
    发明授权
    Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects 有权
    用于选择刺激部位并进行治疗的系统和方法，包括治疗帕金森病症状，其他运动障碍和/或药物副作用

    公开(公告)号：US07565200B2

    公开(公告)日：2009-07-21

    申请号：US10986614

    申请日：2004-11-12

    申请人： Allen Wyler ,  Brad Fowler

    发明人： Allen Wyler ,  Brad Fowler

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36067 ,  A61N1/0531 ,  A61N1/0534

    摘要： Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.

    摘要翻译： 公开了用于治疗运动障碍的方法和系统。 根据一个实施例的方法可以包括确定运动障碍影响患者的步态，口腔功能和/或其他功能，以及分别在大脑间裂缝，西尔维亚裂缝或两个裂缝之间施加电刺激。 在另一个实施例中，该方法可以包括从由患者依次执行的多个进程中选择至少一个神经过程以引起患者的肌肉运动（例如，计划过程，发起过程和执行过程） 并且将电刺激施加到与所述至少一个神经过程相关联的患者脑部的位置。

    Apparatus and methods for applying neural stimulation to a patient
    9.
    发明申请
    Apparatus and methods for applying neural stimulation to a patient 失效
    将神经刺激应用于患者的装置和方法

    公开(公告)号：US20050070971A1

    公开(公告)日：2005-03-31

    申请号：US10910775

    申请日：2004-08-02

    申请人： Brad Fowler ,  Bradford Gliner

    发明人： Brad Fowler ,  Bradford Gliner

    IPC分类号： A61N20060101 ,  A61N1/05 ,  A61N1/18 ,  A61N1/36

    CPC分类号： A61N1/36082 ,  A61N1/0531 ,  A61N1/0539

    摘要： Systems and methods for neural stimulation may include a stimulus unit; a first electrode assembly having a first set of contacts; and a second set of contacts. The stimulus unit can be an implantable pulse generator including a first terminal that can be biased at a first signal polarity and a second terminal that can be biased at a second signal polarity. The first electrode assembly includes a support member configured to be placed at the stimulation site, the first set of contacts carried by the support member, and a first lead configured to be attached to the first terminal of the implantable pulse generator for biasing the surface contacts at the first polarity. The second set of contacts is detached from the surface electrode assembly. The second set of contacts can be one or more conductive elements fixed to or forming portions of the implantable pulse generator, or a separate electrode array.

    摘要翻译： 用于神经刺激的系统和方法可以包括刺激单元; 具有第一组触点的第一电极组件; 和第二组联系人。 刺激单元可以是可植入脉冲发生器，其包括可以以第一信号极性偏置的第一端子和可以以第二信号极性偏置的第二端子。 第一电极组件包括被配置为放置在刺激部位的支撑构件，由支撑构件承载的第一组触点，以及构造成附接到可植入脉冲发生器的第一端子的第一引线，用于偏置表面触点 在第一极性。 第二组触点与表面电极组件脱离。 第二组触点可以是固定到可植入脉冲发生器的一部分或形成部分的一个或多个导电元件，或单独的电极阵列。