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    SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY
    1.
    发明申请
    SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 有权
    用于增强或影响神经刺激效能和/或效率的系统和方法

    公开(公告)号：US20120041498A1

    公开(公告)日：2012-02-16

    申请号：US13179133

    申请日：2011-07-08

    申请人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    发明人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    IPC分类号： A61N1/36

    CPC分类号： H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

    摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

    摘要翻译： 公开了用于增强或影响神经刺激效率和/或功效的系统和方法。 在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。 第一和第二时域可以是顺序的，同时的或嵌套的。 刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。 刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。 在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发​​频率以及规则和/或变化的腹内刺激参数的突发模式。 在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

    Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
    3.
    发明授权
    Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
    用于增强或影响神经刺激效率和/或功效的系统和方法

    公开(公告)号：US07483747B2

    公开(公告)日：2009-01-27

    申请号：US11182713

    申请日：2005-07-15

    申请人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    发明人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    IPC分类号： A61N1/00

    CPC分类号： H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

    摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

    摘要翻译： 公开了用于增强或影响神经刺激效率和/或功效的系统和方法。 在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。 第一和第二时域可以是顺序的，同时的或嵌套的。 刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。 刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。 在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发​​频率以及规则和/或变化的腹内刺激参数的突发模式。 在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

    Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
    4.
    发明授权
    Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
    用于增强或影响神经刺激效率和/或功效的系统和方法

    公开(公告)号：US07983762B2

    公开(公告)日：2011-07-19

    申请号：US12327711

    申请日：2008-12-03

    申请人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    发明人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    IPC分类号： A61N1/36

    CPC分类号： H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

    摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

    摘要翻译： 公开了用于增强或影响神经刺激效率和/或功效的系统和方法。 在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。 第一和第二时域可以是顺序的，同时的或嵌套的。 刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。 刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。 在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发​​频率以及规则和/或变化的腹内刺激参数的突发模式。 在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

    Systems and Methods for Enhancing or Affecting Neural Stimulation Efficiency and/or Efficacy
    5.
    发明申请
    Systems and Methods for Enhancing or Affecting Neural Stimulation Efficiency and/or Efficacy 有权
    增强或影响神经刺激效率和/或功效的系统和方法

    公开(公告)号：US20090299435A1

    公开(公告)日：2009-12-03

    申请号：US12327711

    申请日：2008-12-03

    申请人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    发明人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    IPC分类号： A61N1/36

    CPC分类号： H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

    摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

    摘要翻译： 公开了用于增强或影响神经刺激效率和/或功效的系统和方法。 在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。 第一和第二时域可以是顺序的，同时的或嵌套的。 刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。 刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。 在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发​​频率以及规则和/或变化的腹内刺激参数的突发模式。 在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

    Methods for Treating Neurological Disorders, Including Neuropsychiatric and Neuropsychological, Disorders, and Associated Systems
    10.
    发明申请
    Methods for Treating Neurological Disorders, Including Neuropsychiatric and Neuropsychological, Disorders, and Associated Systems 审中-公开
    治疗神经系统疾病，包括神经精神和神经心理学，疾病和相关系统的方法

    公开(公告)号：US20080208285A1

    公开(公告)日：2008-08-28

    申请号：US11961023

    申请日：2007-12-20

    申请人： Brad Fowler ,  Bradford E. Gliner ,  W. Douglas Sheffield ,  Leif R. Sloan

    发明人： Brad Fowler ,  Bradford E. Gliner ,  W. Douglas Sheffield ,  Leif R. Sloan

    IPC分类号： A61N1/02

    CPC分类号： A61N1/36082

    摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure.

    摘要翻译： 公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。 一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。 该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。 如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者 目标措施。 该方法可以进一步包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。