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    Access mechanism for an inaccessible interior of a cabinet
    2.
    发明授权
    Access mechanism for an inaccessible interior of a cabinet 有权

    公开(公告)号：US12102223B2

    公开(公告)日：2024-10-01

    申请号：US17609850

    申请日：2020-05-08

    申请人： Jasbir Singh

    发明人： Jasbir Singh

    IPC分类号： A47B46/00

    CPC分类号： A47B46/00

    摘要： A cabinet and an access mechanism for the cabinet is disclosed. The cabinet may comprise of a door to access the interior. The door and the adjacent coplanar may be mounted movable jointed combination of first type of frames and second type of frames with telescopic slides and/or guide roller assemblies disposed between to impart the freedom of motion in the desired direction upon a suitable actuation. The first type of frames have been provided with an ability to pivot. The pivots being vertical axillar elements. The arrangement of the two types of frames with pivoted vertical axis provides a plurality of assemblies or shelves mounted on respective door and coplanar portion. The shelves are displaced angularly and laterally owing to the actuating mechanism of the door. The assemblies or shelves are interconnected using coupling elements, horizontal arms and a multiplicity of pivot points arranged at pre-determined distances.

    PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
    9.
    发明申请
    PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION 失效
    LTA4H用于治疗炎症的吡咯并噻吩和吡咯烷酮抑制剂

    公开(公告)号：US20080033013A1

    公开(公告)日：2008-02-07

    申请号：US11833313

    申请日：2007-08-03

    申请人： Vincent Sandanayaka ,  Jasbir Singh ,  Lei Zhao ,  Peng Yu ,  Mark E. Gurney

    发明人： Vincent Sandanayaka ,  Jasbir Singh ,  Lei Zhao ,  Peng Yu ,  Mark E. Gurney

    IPC分类号： A61K31/4523 ,  A61K31/4025 ,  A61P1/00 ,  A61P11/00 ,  A61P19/02 ,  A61P29/00 ,  A61P9/00 ,  C07D207/00 ,  C07D221/00 ,  C12N9/99

    CPC分类号： C07D231/12 ,  C07D207/325 ,  C07D207/333 ,  C07D207/34 ,  C07D231/14 ,  C07D231/16

    摘要： Two chemical genera of pyrazolylphenyl and pyrrolylphenyl derivatives are disclosed. They have the general formula: In these compounds ring (a) is a pyrazole or pyrrole; Q is selected from the group consisting of a direct bond, O, S, SO, SO2, NR1, CH2, CF2, and C(O); HET is a 4-7-membered saturated nitrogenous heterocycle; and taken together ZW is H or Z is (CH2)1-10 in which one or two (CH2) may optionally be replaced by —O—, —NR1—, —SO—, —S(O)2—, —C(═O)— or —C═O(NH)—; and W is hydrogen, acyl, hydroxyl, carboxyl, amino, carboxamido, aminoacyl, —COOalkyl, —CHO, heterocyclyl, substituted aryl or substituted heterocyclyl. The compounds are inhibitors of LTA4H (leukotriene A4 hydrolase). They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

    摘要翻译： 公开了吡唑基苯基和吡咯基苯基衍生物的两种化学属。 它们具有以下通式：在这些化合物中，环（a）是吡唑或吡咯; Q选自直接键O，S，SO，SO 2，NR 1，CH 2，CF 3， SUB 2和C（O）; HET是4-7元饱和含氮杂环; 并且合并在一起ZW是H或Z是（CH 2）2 - ，其中一个或两个（CH 2/2）可以任选地被替换 ，-O - ， - SO - ， - S（O）2 - ， - C（ - ） - 或-CO（NH） - ; W是氢，酰基，羟基，羧基，氨基，甲酰胺基，氨基酰基，-COO烷基，-CHO，杂环基，取代的芳基或取代的杂环基。 这些化合物是LTA4H（白三烯A4水解酶）的抑制剂。 它们可用于治疗和预防和预防炎性疾病和病症。