公开(公告)号：US12187806B2

公开(公告)日：2025-01-07

申请号：US17686666

申请日：2022-03-04

Applicant: Development Center for Biotechnology

Inventor： Chun-Chung Lee ,  Yu-Hsun Lo ,  Chu-Bin Liao ,  Chen-Jei Hong ,  Sih-Yu Chen ,  Yen-Yu Wu ,  Szu-Liang Lai ,  Chih-Yung Hu ,  Wen-Bin Ke ,  Ya-Ting Juan ,  Kao-Jean Huang

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61K39/00

Abstract: The present invention relates to a novel antibody, an antigen-binding fragment thereof and the uses of the antibody and fragment, wherein the antibody and the fragment comprise specific complementarity-determining regions (CDRs) and/or specifically bind to human CD73 at specific epitopes.

公开(公告)号：US20170369525A1

公开(公告)日：2017-12-28

申请号：US15541020

申请日：2015-12-31

Applicant: Development Center for Biotechnology ,  DCB-USA LLC

Inventor： Chao-Pin Lee ,  Cheng-Chou Yu ,  Chi-Huey Wong ,  Chuan-Lung Hsu ,  Chun-Chung Lee ,  Shih-Hsien Chuang ,  Ta-Tung Yuan ,  Yi-Jen Chen ,  Yu-Chin Nieh

IPC: C07K1/107 ,  C07K1/08 ,  A61K39/395 ,  C07K16/18 ,  A61K47/68

CPC classification number: C07K1/1077 ,  A61K39/395 ,  A61K47/6803 ,  A61K47/6855 ,  A61K47/6889 ,  A61K49/0043 ,  A61K49/0058 ,  C07K1/08 ,  C07K16/18

Abstract: A method for specific linkage to a glycoprotein includes obtaining a glycoprotein having a monoglycan or diglycan attached thereto; producing a reactive functional group on a sugar unit on the glycoprotein; and coupling a linker or a payload to the reactive functional group on the glycoprotein.

公开(公告)号：US11085062B2

公开(公告)日：2021-08-10

申请号：US16470807

申请日：2017-12-29

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Shih-Chong Tsai ,  Chun-Chung Lee ,  Meng-Sheng Lee ,  Ching-Yao Chen ,  Shih-Hsien Chuang ,  Yi-Jen Chen ,  Win-Yin Wei

IPC: C12P21/00 ,  A61K47/68 ,  C07K16/32

Abstract: A process for modifying glycoproteins is provided. The invention also provides a process for producing glycoprotein-payload conjugates, as well as the conjugates produced thereby.