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8 条记录 (耗时 0.024 秒)

    Methods and compositions for reducing immune response
    1.
    发明授权
    Methods and compositions for reducing immune response 失效
    减少免疫反应的方法和组合物

    公开(公告)号：US06464976B1

    公开(公告)日：2002-10-15

    申请号：US09653474

    申请日：2000-08-31

    申请人： Drake M. LaFace ,  Amena Rahman ,  Paul W. Shabram ,  Van T. Tsai

    发明人： Drake M. LaFace ,  Amena Rahman ,  Paul W. Shabram ,  Van T. Tsai

    IPC分类号： A61K3900

    CPC分类号： C12N15/86 ,  A61K35/16 ,  A61K35/30 ,  A61K48/00 ,  A61M1/3486 ,  A61M1/3496 ,  C12N2710/10343 ,  Y10S514/885

    摘要： The present invention provides an apparatus and method to diminish the pre-existing immune response to the administration of a therapeutic virus by the selective elimination of antiviral antibodies from the serum. The present invention provides a chromatographic material for the elimination of such antibodies. The invention further provides plasmapheresis apparatus comprising this material. The invention further provides methods for the employment of such apparatus as part of therapeutic treatment regiments.

    摘要翻译： 本发明提供了通过从血清中选择性消除抗病毒抗体来减少预先存在的对施用治疗性病毒的免疫应答的装置和方法。 本发明提供了用于消除这种抗体的色谱材料。 本发明进一步提供了包含该材料的血浆去除装置。 本发明还提供了使用这种装置作为治疗治疗团的一部分的方法。

    Calpain inhibitors and their applications
    2.
    发明授权
    Calpain inhibitors and their applications 失效
    钙蛋白酶抑制剂及其应用

    公开(公告)号：US07001770B1

    公开(公告)日：2006-02-21

    申请号：US09416735

    申请日：1999-10-13

    申请人： Isabella A. Atencio ,  Drake M. LaFace ,  Muralidhara Ramachandra ,  Paul W. Shabram

    发明人： Isabella A. Atencio ,  Drake M. LaFace ,  Muralidhara Ramachandra ,  Paul W. Shabram

    IPC分类号： C12N15/00 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

    CPC分类号： C12N15/86 ,  A61K38/1709 ,  A61K38/1758 ,  A61K45/06 ,  C12N2710/10332 ,  C12N2710/10343

    摘要： The present invention provides a method to enhance apoptosis in a cell by the administration of p53 in combination with a calpain inhibitor. The present invention provides a method of increasing the infectivity of a cell to a viral vector by treatment of the cell with a calpain inhibitor. the present invention further provides a method of enhancing transciption of a therapeutic transgene from the CMV promoter. The present invention also provides a method of suppress the in vivo CTL response to viral vectors by the use of calpain inhibitors. The present invention further provides a pharmaceutical formulations of p53 and a calpain inhibitor in a pharmaceutically acceptable carrier. The present invention provides a method of ablating neoplastic cells in a mammalian organism in vivo by the co-administration of a calpain inhibitor and p53. The present invention also provides a method of ablating neoplastic cells in a population of normal cells contaminated by said neoplastic cells ex vivo by the administration of a recombinant adenovirus in combination with a calpain inhibitor to said population.

    摘要翻译： 本发明提供了通过与钙蛋白酶抑制剂组合施用p53来增强细胞凋亡的方法。 本发明提供了通过用钙蛋白酶抑制剂处理细胞来增加细胞对病毒载体的感染性的方法。 本发明还提供了增强来自CMV启动子的治疗性转基因的转录的方法。 本发明还提供了通过使用钙蛋白酶抑制剂抑制对病毒载体的体内CTL应答的方法。 本发明进一步提供药学上可接受的载体中的p53和钙蛋白酶抑制剂的药物制剂。 本发明提供了通过共同给予钙蛋白酶抑制剂和p53来体内在哺乳动物生物体内消化肿瘤细胞的方法。 本发明还提供了一种通过将重组腺病毒与钙蛋白酶抑制剂组合给所述群体而在体外从所述赘生性细胞污染的正常细胞群体中消化肿瘤细胞的方法。

    Methods and compositions to induce antitumor response
    8.
    发明授权
    Methods and compositions to induce antitumor response 失效
    诱导抗肿瘤反应的方法和组合物

    公开(公告)号：US06649158B1

    公开(公告)日：2003-11-18

    申请号：US09416813

    申请日：1999-10-13

    申请人： Drake M. LaFace

    发明人： Drake M. LaFace

    IPC分类号： A01N6300

    CPC分类号： C07K14/4736 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/55522 ,  C07K14/005 ,  C07K2319/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2830/007 ,  C12N2830/008

    摘要： The present invention provides compositions which are engineered to induce killing of tumor cells and concomitantly mobilize differentiate, activate and attract dendritic cells through the expression of cytokines and dendritic cell chemoattractants. The present invention invention is induces multiple stages of dendritic cell differentiation, activation and migration in vivo using gene therapy delivery systems. Moreover, this invention describes the rational design of utilizing viral vectors (preferred vector is rAd) for multiple administrations of targeted delivery to dendritic cells which can promote differentiation and activation of the transduced dendritic cells (thus augmenting in vivo stimulation of T cells, NK cells and B cells. The present invention provides a method to induce an antitumor immune response through the use of such compositions.

    摘要翻译： 本发明提供了被工程化以诱导肿瘤细胞杀伤并伴随动员通过细胞因子和树突细胞化学引诱物的表达来分化，活化和吸引树突状细胞的组合物。 本发明利用基因治疗递送系统诱导体内树突状细胞分化，活化和迁移的多个阶段。 此外，本发明描述了利用病毒载体（优选的载体是rAd）用于多次施用向枝状细胞的靶向递送的合理设计，其可以促进转导的树突状细胞的分化和活化（从而增加T细胞，NK细胞的体内刺激 本发明提供通过使用这些组合物诱导抗肿瘤免疫应答的方法。