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公开(公告)号：US20090087388A1
公开(公告)日：2009-04-02
申请号：US12140334
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K9/12 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K8/49 , A61K38/00 , A61K39/35
CPC分类号： A61K48/00 , A61K31/7088 , A61K39/0008 , A61K2039/55561 , Y02A50/401
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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公开(公告)号：US08426375B2
公开(公告)日：2013-04-23
申请号：US12140334
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K48/00 , A61K31/7088 , A61K39/0008 , A61K2039/55561 , Y02A50/401
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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3.发明授权Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response 有权免疫调节寡核苷酸（IRO）化合物调节基于类似受体的免疫应答公开(公告)号：US08399423B2
公开(公告)日：2013-03-19
申请号：US12244199
申请日：2008-10-02
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K48/00 , A61K31/711 , A61K39/12 , A61K2039/55561 , C12N2730/10134 , C12N2740/16011 , A61K2300/00
摘要： The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs in the prevention and treatment of a disease caused by a pathogen, for example, a DNA or RNA virus.
摘要翻译： 本发明提供免疫调节寡核苷酸（IRO）作为TLR拮抗剂在预防和治疗由病原体例如DNA或RNA病毒引起的疾病中的用途。
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公开(公告)号：US08383598B2
公开(公告)日：2013-02-26
申请号：US12140338
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K48/00 , A61K31/7052 , A61K2039/55561 , Y02A50/414
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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5.发明申请IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE 有权免疫调节寡核苷酸（IRO）化合物，以调节基于类似感受器的免疫应答公开(公告)号：US20090081198A1
公开(公告)日：2009-03-26
申请号：US12140338
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/395 , A61K31/7052 , A61K38/02 , A61P37/06 , A61K38/16 , A61K39/00
CPC分类号： A61K48/00 , A61K31/7052 , A61K2039/55561 , Y02A50/414
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。
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6.发明申请公开(公告)号：US20100035967A1
公开(公告)日：2010-02-11
申请号：US12510469
申请日：2009-07-28
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , FuGang Zhu , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , FuGang Zhu , Sudhir Agrawal
IPC分类号： A61K31/7088 , C07H21/04 , A61P37/00 , A61P29/00
CPC分类号： C12N15/1138 , C12N2310/11
摘要： Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR9. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR9. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR9 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR9 expression and for prevention or treatment of diseases wherein modulation of TLR9 expression would be beneficial are provided.
摘要翻译： 提供反义寡核苷酸化合物，组合物和方法用于下调TLR9的表达。 组合物包含靶向编码TLR9的核酸的反义寡核苷酸。 组合物还可以包含靶向编码TLR9的核酸与其它治疗和/或预防化合物和/或组合物组合的反义寡核苷酸。 提供了这些化合物和组合物用于下调TLR9表达和预防或治疗TLR9表达调节将是有益的疾病的方法。
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7.发明申请MODULATION OF TOLL-LIKE RECEPTOR 7 EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES 审中-公开抗体寡核苷酸表达类似受体受体7的表达调控公开(公告)号：US20100041734A1
公开(公告)日：2010-02-18
申请号：US12534462
申请日：2009-08-03
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , FuGang Zhu , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , FuGang Zhu , Sudhir Agrawal
CPC分类号： A61K31/7105 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要： Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR7. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR7. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR7 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR7 expression and for prevention or treatment of diseases wherein modulation of TLR7 expression would be beneficial are provided.
摘要翻译： 提供反义寡核苷酸化合物，组合物和方法用于下调TLR7的表达。 组合物包含靶向编码TLR7的核酸的反义寡核苷酸。 组合物还可以包含靶向编码TLR7的核酸与其它治疗和/或预防化合物和/或组合物组合的反义寡核苷酸。 提供了这些化合物和组合物用于下调TLR7表达和预防或治疗其中调节TLR7表达将是有益的疾病的方法。
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公开(公告)号：US08377898B2
公开(公告)日：2013-02-19
申请号：US11743876
申请日：2007-05-03
申请人： Ekambar R Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K39/292 , A61K31/7052 , A61K39/12 , A61K2039/55561 , A61K2039/57 , C12N2730/10134 , Y02A50/412
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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9.发明申请Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response 有权免疫调节寡核苷酸（IRO）化合物调节基于类似受体的免疫应答公开(公告)号：US20090060898A1
公开(公告)日：2009-03-05
申请号：US11549048
申请日：2006-10-12
申请人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K31/7088 , A61K39/395 , A61P37/08 , A61P31/00 , A61P29/00 , A61P17/00 , A61P11/06
CPC分类号： C12N15/117 , A61K9/0019 , A61K31/713 , A61K45/06 , A61K48/00 , A61K2039/55561 , C12N2310/17 , C12N2310/314 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2320/31
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。
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10.发明授权公开(公告)号：US08357665B2
公开(公告)日：2013-01-22
申请号：US11549048
申请日：2006-10-12
申请人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： C12N15/117 , A61K9/0019 , A61K31/713 , A61K45/06 , A61K48/00 , A61K2039/55561 , C12N2310/17 , C12N2310/314 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2320/31
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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