公开(公告)号：US08377898B2

公开(公告)日：2013-02-19

申请号：US11743876

申请日：2007-05-03

申请人： Ekambar R Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar R Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K48/00 ,  C12N15/11

CPC分类号： A61K39/292 ,  A61K31/7052 ,  A61K39/12 ,  A61K2039/55561 ,  A61K2039/57 ,  C12N2730/10134 ,  Y02A50/412

摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

公开(公告)号：US20090060898A1

公开(公告)日：2009-03-05

申请号：US11549048

申请日：2006-10-12

申请人： Ekambar R. Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar R. Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K31/7088 ,  A61K39/395 ,  A61P37/08 ,  A61P31/00 ,  A61P29/00 ,  A61P17/00 ,  A61P11/06

CPC分类号： C12N15/117 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/55561 ,  C12N2310/17 ,  C12N2310/314 ,  C12N2310/321 ,  C12N2310/33 ,  C12N2310/335 ,  C12N2320/31

摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。

公开(公告)号：US08357665B2

公开(公告)日：2013-01-22

申请号：US11549048

申请日：2006-10-12

申请人： Ekambar R. Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar R. Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K48/00 ,  C12N15/11

CPC分类号： C12N15/117 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/55561 ,  C12N2310/17 ,  C12N2310/314 ,  C12N2310/321 ,  C12N2310/33 ,  C12N2310/335 ,  C12N2320/31

摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

公开(公告)号：US20090098063A1

公开(公告)日：2009-04-16

申请号：US12244199

申请日：2008-10-02

申请人： Ekambar R. Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar R. Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K31/711 ,  A61K39/395 ,  A61K9/12 ,  A61K8/73

CPC分类号： A61K48/00 ,  A61K31/711 ,  A61K39/12 ,  A61K2039/55561 ,  C12N2730/10134 ,  C12N2740/16011 ,  A61K2300/00

摘要： The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs in the prevention and treatment of a disease caused by a pathogen, for example, a DNA or RNA virus.

摘要翻译： 本发明提供免疫调节寡核苷酸（IRO）作为TLR拮抗剂在预防和治疗由病原体例如DNA或RNA病毒引起的疾病中的用途。

公开(公告)号：US20080089883A1

公开(公告)日：2008-04-17

申请号：US11743876

申请日：2007-05-03

申请人： Ekambar R. Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar R. Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K31/7052 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P1/00 ,  A61P19/02 ,  A61P3/10 ,  A61P33/02

CPC分类号： A61K39/292 ,  A61K31/7052 ,  A61K39/12 ,  A61K2039/55561 ,  A61K2039/57 ,  C12N2730/10134 ,  Y02A50/412

摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。

公开(公告)号：US20090087388A1

公开(公告)日：2009-04-02

申请号：US12140334

申请日：2008-06-17

申请人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K9/12 ,  A61K31/7088 ,  A61K39/00 ,  A61K39/395 ,  A61K8/49 ,  A61K38/00 ,  A61K39/35

CPC分类号： A61K48/00 ,  A61K31/7088 ,  A61K39/0008 ,  A61K2039/55561 ,  Y02A50/401

摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

公开(公告)号：US08426375B2

公开(公告)日：2013-04-23

申请号：US12140334

申请日：2008-06-17

申请人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K48/00 ,  C12N15/11

CPC分类号： A61K48/00 ,  A61K31/7088 ,  A61K39/0008 ,  A61K2039/55561 ,  Y02A50/401

摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

公开(公告)号：US08399423B2

公开(公告)日：2013-03-19

申请号：US12244199

申请日：2008-10-02

申请人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K48/00 ,  C12N15/11

CPC分类号： A61K48/00 ,  A61K31/711 ,  A61K39/12 ,  A61K2039/55561 ,  C12N2730/10134 ,  C12N2740/16011 ,  A61K2300/00

摘要： The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs in the prevention and treatment of a disease caused by a pathogen, for example, a DNA or RNA virus.

摘要翻译： 本发明提供免疫调节寡核苷酸（IRO）作为TLR拮抗剂在预防和治疗由病原体例如DNA或RNA病毒引起的疾病中的用途。

公开(公告)号：US08383598B2

公开(公告)日：2013-02-26

申请号：US12140338

申请日：2008-06-17

申请人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K48/00 ,  C12N15/11

CPC分类号： A61K48/00 ,  A61K31/7052 ,  A61K2039/55561 ,  Y02A50/414

摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

公开(公告)号：US20090081198A1

公开(公告)日：2009-03-26

申请号：US12140338

申请日：2008-06-17

申请人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

发明人： Ekambar Kandimalla ,  Daqing Wang ,  Yukui Li ,  Dong Yu ,  FuGang Zhu ,  Lakshmi Bhagat ,  Sudhir Agrawal

IPC分类号： A61K39/395 ,  A61K31/7052 ,  A61K38/02 ,  A61P37/06 ,  A61K38/16 ,  A61K39/00

CPC分类号： A61K48/00 ,  A61K31/7052 ,  A61K2039/55561 ,  Y02A50/414

摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。