公开(公告)号：US20230291163A1

公开(公告)日：2023-09-14

申请号：US18309870

申请日：2023-05-01

Applicant: Emad Eskandar

Inventor： Emad N. Eskandar ,  James Joseph Cohen

IPC: H01S1/04 ,  H01S4/00 ,  H01S1/02 ,  H01S1/00 ,  A61B90/00 ,  A61B18/18 ,  A61N5/04 ,  H01S1/06

CPC classification number: H01S1/04 ,  H01S4/00 ,  H01S1/02 ,  H01S1/005 ,  A61B90/36 ,  A61B18/1815 ,  A61N5/045 ,  H01S1/06 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2018/0016

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

公开(公告)号：US11944839B2

公开(公告)日：2024-04-02

申请号：US18309870

申请日：2023-05-01

Applicant: Emad Eskandar

Inventor： Emad N. Eskandar ,  James Joseph Cohen

IPC: A61N5/04 ,  A61B18/00 ,  A61B18/18 ,  A61B90/00 ,  A61N5/02 ,  H01S1/02 ,  H01S1/06

CPC classification number: A61N5/045 ,  A61B18/1815 ,  A61B90/36 ,  H01S1/02 ,  H01S1/06 ,  A61B2018/0016 ,  A61B2018/00446 ,  A61B2018/00577 ,  A61B2018/1861 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N2005/027

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

公开(公告)号：US11872386B2

公开(公告)日：2024-01-16

申请号：US17148215

申请日：2021-01-13

Applicant: Emad Eskandar

Inventor： James Joseph Cohen ,  Emad N. Eskandar

IPC: H01S1/02 ,  A61N5/04 ,  A61B90/00 ,  A61B18/18 ,  H01S1/06 ,  A61B18/00 ,  A61N5/02

CPC classification number: A61N5/045 ,  A61B18/1815 ,  A61B90/36 ,  H01S1/02 ,  H01S1/06 ,  A61B2018/0016 ,  A61B2018/00446 ,  A61B2018/00577 ,  A61B2018/1861 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N2005/027

Abstract: A MASER (Microwave Amplified Stimulated Emission of Radiation) emitter is fabricated of thin film components, including a thin film of nitrogen-implanted, epitaxial crystal diamond. The MASER elements can also include a controllable Q-switching layer and be arranged in a thin panel, phased array to generate a single beam of coherent, mode-locked, continuous wave MASER radiation.

公开(公告)号：US11641088B2

公开(公告)日：2023-05-02

申请号：US17148275

申请日：2021-01-13

Applicant: Emad Eskandar

Inventor： James Joseph Cohen ,  Emad N. Eskandar

IPC: H01S4/00 ,  H01S1/04 ,  H01S1/02 ,  H01S1/00 ,  A61B90/00 ,  A61B18/18 ,  A61N5/04 ,  H01S1/06 ,  A61B18/00 ,  A61N5/02

Abstract: A phased-array MASER detector for synthetic aperture interferometric three-dimensional imaging. The detector elements, for example 102-106 zero bias Schottky detector diodes with sufficient sensitivity to reliably detect various values of MASER radiation, are arranged in layers offset in three dimensions. The phased-array MASER detector is particularly useful for detecting characteristics in a biological object using low energy (2-10 Watts), coherent MASER radiation. MASER intensity data of an interferometric pattern is collected by the detector array, is deconvolved, and is used to generate three-dimensional energy activity maps for a given time slice or on a time-shifting basis.

公开(公告)号：US11641087B2

公开(公告)日：2023-05-02

申请号：US17148120

申请日：2021-01-13

Applicant: Emad Eskandar

Inventor： Emad N. Eskandar ,  James Joseph Cohen

IPC: H01S1/04 ,  H01S4/00 ,  H01S1/02 ,  H01S1/00 ,  A61B90/00 ,  A61B18/18 ,  A61N5/04 ,  H01S1/06 ,  A61B18/00 ,  A61N5/02

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.