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7 条记录 (耗时 0.026 秒)

    4-Phenyl-4,5,6,7-tetrahydro-thieno [2,3-c]pyridines, compositions and use
    4.
    发明授权
    4-Phenyl-4,5,6,7-tetrahydro-thieno [2,3-c]pyridines, compositions and use 失效
    4-苯基-4,5,6,7-四氢 - 噻吩并[2,3-c]吡啶，组合物和用途

    公开(公告)号：US4482559A

    公开(公告)日：1984-11-13

    申请号：US466100

    申请日：1983-02-14

    申请人： Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Weber ,  Wolf D. Bechtel ,  Karin Boke-Kuhn

    发明人： Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Weber ,  Wolf D. Bechtel ,  Karin Boke-Kuhn

    IPC分类号： A61K31/435 ,  A61P25/24 ,  A61P25/26 ,  C07D495/04 ,  A61K31/44

    CPC分类号： C07D495/04

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl;R.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring where, in the case of a 6-membered ring, a --CH.sub.2 -group in the ring may be replaced by an oxygen atom, and non-toxic, pharmacologically acceptable salts thereof. The compounds as well as their salts are useful as antidepressants.

    摘要翻译： 其中R 1是氨基，乙酰氨基，羟甲基，甲氧基甲基或者R 2和R 3的式（I）化合物可以相同或不同，分别是氢，氟，氯，溴，三氟甲基 ，羟基，甲氧基，甲基或乙基; R4是1〜3个碳原子的直链或支链烷基; 和可以相同或不同的R 5和R 6各自为氢或1至4个碳原子的烷基，或彼此连接并与它们相连的氮原子形成5-，6- 或7-元杂环，其中在6元环的情况下，环中的-CH 2 - 基可被氧原子取代，及其无毒的药学上可接受的盐。 化合物及其盐可用作抗抑郁药。

    4-Phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridines and salts thereof, compositions and use
    5.
    发明授权
    4-Phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridines and salts thereof, compositions and use 失效
    4-苯基-4,5,6,7-四氢 - 噻吩并[2,3-c]吡啶及其盐，组合物和用途

    公开(公告)号：US4550106A

    公开(公告)日：1985-10-29

    申请号：US630376

    申请日：1984-07-23

    申请人： Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Weber ,  Wolf D. Bechtel ,  Karin Boke-Kuhn

    发明人： Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Weber ,  Wolf D. Bechtel ,  Karin Boke-Kuhn

    IPC分类号： A61K31/435 ,  A61P25/24 ,  A61P25/26 ,  C07D495/04 ,  A61K31/44 ,  A61K31/535

    CPC分类号： C07D495/04

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl;R.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring where, in the case of a 6-membered ring, a --CH.sub.2 -group in the ring may be replaced by an oxygen atom,and non-toxic, pharmacologically acceptable salts thereof. The compounds as well as their salts are useful as antidepressants.

    摘要翻译： 其中R 1是氨基，乙酰氨基，羟甲基，甲氧基甲基或者R 2可以相同或不同的式（I）化合物分别是氢，氟，氯，溴，三氟甲基 ，羟基，甲氧基，甲基或乙基; R4是1〜3个碳原子的直链或支链烷基; 和可以相同或不同的R 5和R 6各自为氢或1至4个碳原子的烷基，或彼此连接并与它们相连的氮原子形成5-，6- 或7-元杂环，其中在6元环的情况下，环中的-CH 2 - 基可被氧原子取代，及其无毒的药学上可接受的盐。 化合物及其盐可用作抗抑郁药。