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    4-Phenyl-4,5,6,7-tetrahydro-thieno [2,3-c]pyridines, compositions and use
    1.
    发明授权
    4-Phenyl-4,5,6,7-tetrahydro-thieno [2,3-c]pyridines, compositions and use 失效
    4-苯基-4,5,6,7-四氢 - 噻吩并[2,3-c]吡啶，组合物和用途

    公开(公告)号：US4482559A

    公开(公告)日：1984-11-13

    申请号：US466100

    申请日：1983-02-14

    申请人： Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Weber ,  Wolf D. Bechtel ,  Karin Boke-Kuhn

    发明人： Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Weber ,  Wolf D. Bechtel ,  Karin Boke-Kuhn

    IPC分类号： A61K31/435 ,  A61P25/24 ,  A61P25/26 ,  C07D495/04 ,  A61K31/44

    CPC分类号： C07D495/04

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl;R.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring where, in the case of a 6-membered ring, a --CH.sub.2 -group in the ring may be replaced by an oxygen atom, and non-toxic, pharmacologically acceptable salts thereof. The compounds as well as their salts are useful as antidepressants.

    摘要翻译： 其中R 1是氨基，乙酰氨基，羟甲基，甲氧基甲基或者R 2和R 3的式（I）化合物可以相同或不同，分别是氢，氟，氯，溴，三氟甲基 ，羟基，甲氧基，甲基或乙基; R4是1〜3个碳原子的直链或支链烷基; 和可以相同或不同的R 5和R 6各自为氢或1至4个碳原子的烷基，或彼此连接并与它们相连的氮原子形成5-，6- 或7-元杂环，其中在6元环的情况下，环中的-CH 2 - 基可被氧原子取代，及其无毒的药学上可接受的盐。 化合物及其盐可用作抗抑郁药。

    4-Phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridines and salts thereof, compositions and use
    2.
    发明授权
    4-Phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridines and salts thereof, compositions and use 失效
    4-苯基-4,5,6,7-四氢 - 噻吩并[2,3-c]吡啶及其盐，组合物和用途

    公开(公告)号：US4550106A

    公开(公告)日：1985-10-29

    申请号：US630376

    申请日：1984-07-23

    申请人： Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Weber ,  Wolf D. Bechtel ,  Karin Boke-Kuhn

    发明人： Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Weber ,  Wolf D. Bechtel ,  Karin Boke-Kuhn

    IPC分类号： A61K31/435 ,  A61P25/24 ,  A61P25/26 ,  C07D495/04 ,  A61K31/44 ,  A61K31/535

    CPC分类号： C07D495/04

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl;R.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring where, in the case of a 6-membered ring, a --CH.sub.2 -group in the ring may be replaced by an oxygen atom,and non-toxic, pharmacologically acceptable salts thereof. The compounds as well as their salts are useful as antidepressants.

    摘要翻译： 其中R 1是氨基，乙酰氨基，羟甲基，甲氧基甲基或者R 2可以相同或不同的式（I）化合物分别是氢，氟，氯，溴，三氟甲基 ，羟基，甲氧基，甲基或乙基; R4是1〜3个碳原子的直链或支链烷基; 和可以相同或不同的R 5和R 6各自为氢或1至4个碳原子的烷基，或彼此连接并与它们相连的氮原子形成5-，6- 或7-元杂环，其中在6元环的情况下，环中的-CH 2 - 基可被氧原子取代，及其无毒的药学上可接受的盐。 化合物及其盐可用作抗抑郁药。

    4-Phenyl-4,5,6,7-tetrahydro-pyrrolo [2,3-c] pyridines and salts thereof
    8.
    发明授权
    4-Phenyl-4,5,6,7-tetrahydro-pyrrolo [2,3-c] pyridines and salts thereof 失效
    4-苯基-4,5,6,7-四氢 - 吡咯并[2,3-c]吡啶及其盐

    公开(公告)号：US4315938A

    公开(公告)日：1982-02-16

    申请号：US163969

    申请日：1980-06-30

    申请人： Claus Schneider ,  Karl-Heinz Weber ,  Gerhard Walther ,  Karin Boke ,  Wolf D. Bechtel

    发明人： Claus Schneider ,  Karl-Heinz Weber ,  Gerhard Walther ,  Karin Boke ,  Wolf D. Bechtel

    IPC分类号： A61K31/435 ,  A61K31/445 ,  A61K31/535 ,  A61P25/02 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07D207/32 ,  C07D207/335 ,  C07D471/04 ,  A61K31/44

    CPC分类号： C07D207/335 ,  C07D471/04

    摘要： Compounds of the formula ##STR1## wherein R.sub.2 is hydrogen, chlorine, bromine, formyl, acetyl, alkyl of 1 to 4 carbon atoms, nitro, cyano or --CH.sub.2 --A;whereA is (alkyl of 1 to 2 carbon atoms)-amino; di(alkyl of 1 to 2 carbon atoms)-amino, where one of the alkyl moieties may have a terminal hydroxyl substituent attached thereto; or a 5-, 6- or 7-membered saturated, nitrogen-containing heterocycle which is attached to the methylene group through the nitrogen atom and may have a hydroxyl or hydroxymethyl substituent attached to a ring carbon atom, and the 6-membered heterocycle may contain oxygen as an additional ring heteroatom in the p-position;R.sub.3 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy; andR.sub.4 is hydrogen or alkyl of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.

    摘要翻译： 其中R2是氢，氯，溴，甲酰基，乙酰基，1-4个碳原子的烷基，硝基，氰基或-CH2-A的式 其中A是（1至2个碳原子的烷基） - 氨基; 二（1至2个碳原子的烷基） - 氨基，其中一个烷基部分可以具有连接到其上的末端羟基取代基; 或通过氮原子连接到亚甲基并且可以具有连接到环碳原子上的羟基或羟甲基取代基的5-，6-或7-元饱和的含氮杂环，并且所述6元杂环可以 在对位含有氧作为另外的环杂原子; R3是氢，氟，氯，溴，甲基或甲氧基; R4为氢或1〜3个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作抗抑郁药。

    Substituted 4-amino-2,6-diaryl-tetrahydrothiopyrans and salts thereof, and use as antidepressants
    9.
    发明授权
    Substituted 4-amino-2,6-diaryl-tetrahydrothiopyrans and salts thereof, and use as antidepressants 失效
    取代的4-氨基-2,6-二芳基 - 四氢噻喃及其盐，并用作抗抑郁剂

    公开(公告)号：US4297354A

    公开(公告)日：1981-10-27

    申请号：US216423

    申请日：1980-12-15

    申请人： Karl-Heinz Weber ,  Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Pook ,  Karin Boke ,  Wolf D. Bechtel

    发明人： Karl-Heinz Weber ,  Claus Schneider ,  Gerhard Walther ,  Karl-Heinz Pook ,  Karin Boke ,  Wolf D. Bechtel

    IPC分类号： A61K31/38 ,  A61K31/382 ,  A61P25/24 ,  A61P25/26 ,  C07D335/02 ,  C07D409/04 ,  C07D409/14 ,  A61K31/445

    CPC分类号： C07D335/02

    摘要： Compounds of the steroisomeric formulas ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each phenyl, substituted phenyl, thienyl or furyl;R.sub.3 is hydrogen or straight or branched alkyl of 1 to 3 carbon atoms; andR.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; orR.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form a piperidino, 4-amino-piperidino, 4-(lower alkylamino)-piperidino, piperazino, 4-(alkyl of 1 to 2 carbon atoms)-piperazino or morpholino radical; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.

    摘要翻译： 立体异构体式“IMAGE”和“IMAGE”的化合物，其中可以相同或不同的R 1和R 2各自为苯基，取代的苯基，噻吩基或呋喃基; R3是氢或1〜3个碳原子的直链或支链烷基; R4为1〜3个碳原子的直链或支链烷基; 或R 3和R 4彼此连接并与它们相连的氮原子形成哌啶子基，4-氨基 - 哌啶子基，4-（低级烷基氨基） - 哌啶子基，哌嗪基，4-（1至2个碳原子的烷基） ） - 哌嗪基或吗啉基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作抗抑郁药。