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公开(公告)号：US10253015B2
公开(公告)日：2019-04-09
申请号：US15964812
申请日：2018-04-27
Applicant: FORMA TM2, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D413/14 , C07D401/14 , C07D417/14 , C07D405/14 , A61K31/4704
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
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2.发明授权公开(公告)号：US10294206B2
公开(公告)日：2019-05-21
申请号：US15568051
申请日：2015-09-18
Applicant: FORMA TM2, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D215/227 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , A61P35/00
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：US20190210970A1
公开(公告)日：2019-07-11
申请号：US16235542
申请日：2018-12-28
Applicant: FORMA TM2, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC: C07D215/227 , A61K31/4709 , C07D471/04 , C07D401/12 , C07D405/12 , C07D409/12
CPC classification number: C07D215/227 , A61K31/4709 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
Abstract: The invention relates to methods of reducing the level of 2-hydroxyglutarate in cells by administration of an inhibitor of mutant isocitrate dehydrogenase-1.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20190202790A1
公开(公告)日：2019-07-04
申请号：US16351457
申请日：2019-03-12
Applicant: FORMA TM2, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC: C07D215/227 , C07D519/00 , A61P35/00 , C07D401/14 , C07D498/04 , C07D471/04 , C07D403/12 , C07D417/12 , C07D413/12 , C07D405/12 , C07D401/12 , C07D487/04
CPC classification number: C07D215/227 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：US20190210995A1
公开(公告)日：2019-07-11
申请号：US16235524
申请日：2018-12-28
Applicant: FORMA TM2, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D403/12 , C07D409/14 , C07D471/04 , C07D405/14 , C07D417/14 , C07D401/14 , C07D413/14
CPC classification number: C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The invention relates to methods of reducing the level of 2-hydroxyglutarate in cells by administration of an inhibitor of mutant isocitrate dehydrogenase-1.
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公开(公告)号：US10280150B2
公开(公告)日：2019-05-07
申请号：US15712446
申请日：2017-09-22
Applicant: FORMA TM2, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , A61K31/506 , C07D405/14 , C07D401/14 , C07D417/14 , C07D413/14 , C07D471/04 , C07D409/14 , C07D403/12
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：US20190135781A1
公开(公告)日：2019-05-09
申请号：US16235505
申请日：2018-12-28
Applicant: FORMA TM2, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D417/14 , C07D405/14 , C07D413/14 , C07D401/14
Abstract: The invention relates to methods of reducing the level of 2-hydroxyglutarate in cells by administration of an inhibitor of mutant isocitrate dehydrogenase-1.
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公开(公告)号：US10266495B2
公开(公告)日：2019-04-23
申请号：US15977512
申请日：2018-05-11
Applicant: FORMA TM2, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D215/227 , A61K31/4709 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R8 are described herein.
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