公开(公告)号：US20230414669A1

公开(公告)日：2023-12-28

申请号：US18463631

申请日：2023-09-08

Applicant: FUJIFILM Corporation ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Kentaro NAKAMURA ,  Shunsuke TOMINAGA ,  Ichiro SEKIYA ,  Mitsuru MIZUNO ,  Hisako KATANO ,  Nobutake OZEKI

IPC: A61K35/28 ,  C12N5/0775 ,  G01N1/40 ,  A61P19/02 ,  G06T7/60 ,  G06T7/00

CPC classification number: A61K35/28 ,  C12N5/0668 ,  G01N1/4044 ,  A61P19/02 ,  G06T7/60 ,  G06T7/0012 ,  G06T2207/30024

Abstract: There are provided a production method for a therapeutic agent for arthrosis, in which a population including a plurality of mesenchymal stem cells being cultured is imaged to acquire a cell image, the cell image is analyzed to derive density information on the mesenchymal stem cells in the cell image, colonies, which are formed by the mesenchymal stem cells in the population, are detected based on the density information, and the population is sorted based on at least one of an average colony size or a colony forming unit, which is derived from the detected colonies, and provided a therapeutic agent for arthrosis, which is produced by the production method for a therapeutic agent for arthrosis.

公开(公告)号：US20240299459A1

公开(公告)日：2024-09-12

申请号：US18590366

申请日：2024-02-28

Applicant: FUJIFILM Corporation ,  National University Corporation Tokyo Medical and Dental University

Inventor： Tsukasa KITAHASHI ,  Ryo KOGAWA ,  Kentaro NAKAMURA ,  Ichiro SEKIYA

IPC: A61K35/28 ,  A61P19/02 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61P19/02 ,  C12N5/0668

Abstract: An object of the present invention is to provide a therapeutic agent for arthrosis, which contains synovium-derived mesenchymal stem cells having a molecule essential for joint medical treatment, and a production method for the therapeutic agent for arthrosis. According to the present invention, there is provided a therapeutic agent for arthrosis, which contains synovium-derived mesenchymal stem cells having any one or more kinds of surface antigens of integrin β1 or platelet-derived growth factor receptor β.

公开(公告)号：US20210390764A1

公开(公告)日：2021-12-16

申请号：US17460291

申请日：2021-08-29

Applicant: FUJIFILM Corporation

Inventor： Ichiro SEKIYA ,  Nobutake OZEKI ,  Akinobu HYODO ,  Hayato AOKI ,  Kenji SUZUKI ,  Jun MASUMOTO

IPC: G06T15/10 ,  G06K9/20 ,  G06T7/00 ,  G06T7/11 ,  G06T7/62 ,  A61B5/00

Abstract: A joint image unfolding apparatus, a joint image unfolding method, and a non-transitory computer readable recording medium storing a joint image unfolding program are provided to make it possible to check information regarding the entire cartilage in a joint with high accuracy. An image obtaining unit (21) obtains a three-dimensional image of a joint having cartilage. An unfolding unit (23) unfolds the cartilage included in the three-dimensional image with reference to a specific reference axis in the joint to generate an unfolded image.

公开(公告)号：US20230132346A1

公开(公告)日：2023-04-27

申请号：US18146109

申请日：2022-12-23

Applicant: FUJIFILM Corporation ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Ichiro SEKIYA ,  Mitsuru MIZUNO ,  Hisako KATANO ,  Nobutake OZEKI ,  Kentaro NAKAMURA ,  Tomomi YOSHIDA

IPC: C12N5/0775 ,  C12N9/64 ,  A61P19/00

Abstract: An object of the present invention is to provide a production method for a synovium-derived mesenchymal stem cell, which makes it possible to obtain a sufficient amount of synovium-derived mesenchymal stem cells from the synovial tissue, a production method for a cell preparation for joint medical treatment using the production method for a synovium-derived mesenchymal stem cell, synovium-derived mesenchymal stem cell, and a cell preparation for a joint medical treatment. According to the present invention, there is provided a production method for a synovium-derived mesenchymal stem cell, which includes treating a synovial tissue with an enzyme for 2 hours or more; and washing a mixture after the enzyme treatment until a residual enzyme concentration in a supernatant is 0.5 ng/mL or less, to obtain a synovium-derived mesenchymal stem cell.

公开(公告)号：US20230130549A1

公开(公告)日：2023-04-27

申请号：US18145922

申请日：2022-12-23

Applicant: FUJIFILM Corporation ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

Inventor： Ichiro SEKIYA ,  Mitsuru MIZUNO ,  Hisako KATANO ,  Nobutake OZEKI ,  Kentaro NAKAMURA ,  Tomomi YOSHIDA

IPC: C12N5/0775

Abstract: An object of the present invention is to provide a production method for a synovium-derived mesenchymal stem cell, by which proliferation efficiency is improved so that a sufficient amount of synovium-derived mesenchymal stem cells can be obtained from a synovial tissue, a production method for a cell preparation for joint medical treatment using the production method for a synovium-derived mesenchymal stem cell, synovium-derived mesenchymal stem cell, and a cell preparation for a joint medical treatment. According to the present invention, there is provided a production method for a synovium-derived mesenchymal stem cell, which is a method of producing a synovium-derived mesenchymal stem cell from a synovial tissue, where the production method includes treating the synovial tissue with a mixed enzyme including one or more kinds of collagenases and one or more kinds of neutral proteases for 2 hours or more without causing the synovial tissue to undergo a disinfection step.