公开(公告)号：US12123814B1

公开(公告)日：2024-10-22

申请号：US16900019

申请日：2020-06-12

申请人： Pierce Biotechnology, Inc.

发明人： Barbara Kaboord ,  Joanna Geddes ,  Christopher Wojewodzki ,  Kay Opperman ,  Scott Meier

IPC分类号： C07K1/14 ,  C07K14/705 ,  C07K14/72 ,  G01N1/40 ,  C07H3/04 ,  C07J9/00 ,  C07J41/00

CPC分类号： G01N1/4044 ,  C07K1/145 ,  C07K14/705 ,  C07K14/723 ,  C07H3/04 ,  C07J9/00 ,  C07J41/0033 ,  G01N2001/4061

摘要： Formulations for extraction and stabilization of G-Protein Coupled Receptors (GPCRs), kits and methods for their use for extracting GPCRs from biological specimens (e.g., cells and tissues), and methods for making such formulations in bulk scale are described. GPCRs extracted from cells and tissues using the described formulations remain in a functional, solubilized form over extended time periods.

公开(公告)号：US12103910B1

公开(公告)日：2024-10-01

申请号：US18244938

申请日：2023-09-12

申请人： KING FAISAL UNIVERSITY

发明人： Hany Mohamed Abd El-Lateef Ahmed ,  Saadeldin Elsayed Ibrahim Shabaan ,  Mai Mustafa Khalaf Ali ,  Mohamed Gouda ,  Wael I. Mortada

IPC分类号： C07C391/02 ,  G01N1/40 ,  G01N33/18

CPC分类号： C07C391/02 ,  G01N1/4044 ,  G01N33/1813 ,  Y10T436/107497 ,  Y10T436/255

摘要： Novel organoselenium selective ligands are presented and designed to determine metal ions in a sample. These ligands are used as complexing agents in a dispersive liquid-liquid microextraction procedure of copper and zinc ions. The procedure has a shortened extraction time, minimal organic solvent types, and lower amounts of solvents, as well as easy operation and high enrichment efficiency.

公开(公告)号：US20240125720A1

公开(公告)日：2024-04-18

申请号：US18476786

申请日：2023-09-28

申请人： PETRÓLEO BRASILEIRO S.A. - PETROBRAS ,  UNIVERSIDADE FEDERAL DE GOIÁS

发明人： RODRIGO CABRAL DA SILVA ,  DANIELLE MITZE MULLER FRANCO ,  YGOR DOS SANTOS ROCHA ,  JOELMA PIMENTEL LOPES ,  GABRIEL HENRY MORAIS DUFRAYER ,  MÁRIO DUNCAN RANGEL ,  ROSANA CARDOSO LOPES PEREIRA ,  BONIEK GONTIJO VAZ ,  TAYNARA RODRIGUES COVAS ,  JUSSARA VALENTE ROQUE ,  ROSINEIDE COSTA SIMAS

IPC分类号： G01N24/14 ,  G01N1/40

CPC分类号： G01N24/14 ,  G01N1/4044

摘要： The invention teaches a method proposing two new indices for evaluating thermal evolution in oils from different basins and organofacies. The first index is based on the distribution ratio of high molecular weight sulfur compounds, belonging to the DBE 6 (benzothiophene) and DBE 9 (dibenzothiophene) series. The second index, called TEI, was created from the profile of aromatic hydrocarbons and molecules containing N, O and S. Both parameters were obtained from the direct characterization of the oils, by using the photoionization at atmospheric pressure (APPI) technique combined with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).

公开(公告)号：US11856945B2

公开(公告)日：2024-01-02

申请号：US16606482

申请日：2018-04-20

申请人： Srikanth Singamaneni ,  Congzhou Wang ,  Jeremiah J. Morrissey ,  Evan D. Kharasch

发明人： Srikanth Singamaneni ,  Congzhou Wang ,  Jeremiah J. Morrissey ,  Evan D. Kharasch

IPC分类号： G01N33/68 ,  G01N21/33 ,  G01N21/64 ,  G01N33/52 ,  C07C309/05 ,  C07C309/73 ,  A01N1/02 ,  G01N1/40

CPC分类号： A01N1/0231 ,  G01N1/4044

摘要： Methods and systems for preparing and preserving biological samples are disclosed herein. A method comprises contacting a preserving agent with a biological sample to form a mixture, wherein the preserving agent is selected from at least one of a metal-organic framework (MOF) encapsulant or a precursor forming a MOF encapsulant, and wherein the biological sample comprises at least one target analyte. A system comprises a preserving agent selected from at least one of a metal-organic framework (MOF) encapsulant or a precursor forming a MOF encapsulant; and a substrate configured to receive a drop cast mixture of the preserving agent and a biological sample, wherein the biological sample comprises at least one target analyte.

公开(公告)号：US11781952B2

公开(公告)日：2023-10-10

申请号：US18059166

申请日：2022-11-28

申请人： Bruker Daltonics GmbH & Co. KG

发明人： Martin Schürenberg ,  Sören-Oliver Deininger ,  Alice Ly

IPC分类号： G01N1/28 ,  G01N1/40 ,  G01N33/68 ,  H01J49/04

CPC分类号： G01N1/28 ,  G01N1/4044 ,  G01N33/6851 ,  H01J49/0418

摘要： The invention proposes preparing biological samples for spectrometry which contain cell structures and/or whole cells of human or animal origin (e.g. thin human and animal tissue sections) or prokaryotes (e.g. microorganisms), and which require constant relative humidity, in a temperature-controlled gas volume whose humidity is determined by a saturated substance solution, for example a suitable salt solution. The invention exploits a physico-chemical phenomenon called “deliquescence”, which manifests itself by keeping the relative humidity above the saturated substance solution constant with a high degree of precision when a specified temperature is maintained. Pure succinic acid exhibits deliquescence at approx. 99% relative humidity, for example. Since an enormous variety of deliquescent salts and other suitable substances are available, it is possible to find the suitable substance for almost any desired relative humidity, with adjustment of the temperature, where necessary.

公开(公告)号：US20230184640A1

公开(公告)日：2023-06-15

申请号：US18161378

申请日：2023-01-30

申请人： BIS SCIENCE LLC

发明人： Marc W. GUNDERSON ,  Paul DABNEY

IPC分类号： G01N1/34 ,  G01N1/40

CPC分类号： G01N1/34 ,  G01N1/4044

摘要： A method for differentially lysing a liquid sample or target material using an augmented oxidizing agent (AOA), which includes a quantity of electronically modified oxygen derivatives (EMODs). The method reduces or eliminates total dissolved solids (IDS), total suspended solids (TSS), Biologic Oxygen Demand (BOD), microbial concentration, biofilms and other content in the liquid target material known or suspected to contain animal fluids, blood and blood cells and suspected or known to contain eukaryotic cells, microbial cells, bacteria, viruses, spores, fungi, prions, organic matter, minerals, proteins or associated structures. The BOD, TDS and TSS can be lowered or eliminated as desired. This action is directly proportional to the quantity of EMODs in the AOS applied to the liquid target material.

公开(公告)号：US20190234890A1

公开(公告)日：2019-08-01

申请号：US16314221

申请日：2017-06-30

申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

发明人： Melvyn LINTERN

IPC分类号： G01N23/223 ,  G01N23/2202 ,  G01N1/38 ,  G01N1/40

CPC分类号： G01N23/223 ,  G01N1/38 ,  G01N1/4044 ,  G01N1/405 ,  G01N23/2202 ,  G01N2223/076 ,  G01N2223/301 ,  G01N2223/307 ,  G01N2223/616

摘要： A collector device for determining a metal in an exploration sample containing a concentration of the metal not directly detectable by X-ray fluorescence (XRF), comprises an adsorbent material capable of concentrating metal from a digestion mixture produced by digesting the exploration sample, which is configured for association with an analysis window of the XRF detector to facilitate determination of the amount of metal value in the exploration sample. A sample preparation vessel, method and system used to prepare exploration samples for analysis includes a vessel for receiving the exploration sample, a digestion tablet and a digestion medium; a closure to allow the vessel to be agitated to produce a digestion mixture comprising dissolved metal and the collector device. The closure and the collector device are coupled so that collector device is retrieved from the vessel by removing the closure. The digestion tablet includes a metal lixiviate and an alkali compound.

公开(公告)号：US20180348106A1

公开(公告)日：2018-12-06

申请号：US15770453

申请日：2016-02-27

申请人： Hewlett-Packard Development Company, L.P.

发明人： Viktor SHKOLNIKOV ,  Anita ROGACS

IPC分类号： G01N1/40 ,  B01L3/00 ,  G01N21/65

CPC分类号： G01N1/4044 ,  B01L3/5027 ,  B01L2200/0678 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0478 ,  B01L2400/0487 ,  G01N21/648 ,  G01N21/658 ,  G01N2001/4088

摘要： A sample preparation system includes a sample input, a first chamber fluidly coupled to the sample input and containing a sample preparation reagent, a second chamber containing a surface enhanced Raman spectroscopy (SERS) sensor structure and a third chamber containing a sensor preparation solution. The sample input, the first chamber and the second chamber are fluidly coupled to one another in a series and the third chamber is fluidly coupled to the third chamber outside of the series so as to sequentially direct a sample received by the sample input through the first chamber to the second chamber and out of the second chamber and so as to direct the sensor preparation solution into the second chamber following discharge of the sample out of the second chamber.

公开(公告)号：US20180001260A1

公开(公告)日：2018-01-04

申请号：US15689962

申请日：2017-08-29

申请人： Cooper Environmental Services LLC

发明人： John Arthur Cooper

IPC分类号： B01D53/83 ,  B01D53/96 ,  B01D53/64 ,  B01D53/68 ,  G01N1/40

CPC分类号： B01D53/83 ,  B01D53/64 ,  B01D53/68 ,  B01D53/96 ,  B01D2251/108 ,  B01D2257/2045 ,  G01N1/4044 ,  G01N1/405

摘要： A duct can be configured to receive a denuding gas flow. A solid denuding surface that is connected to a drive system can be configured to move the solid denuding surface within the duct while the solid denuding surface is continuously concentrating one or more gas-phase species from the denuding gas flow on the denuding surface. Also, a denuding gas flow can be passed along a denuding surface to concentrate one or more gas phase species from the denuding gas flow onto the denuding surface with a diffusion denuding action. The denuding surface can be moved while continuing to concentrate the one or more gas phase species from the denuding gas flow onto the denuding surface.

公开(公告)号：US09848853B2

公开(公告)日：2017-12-26

申请号：US15143925

申请日：2016-05-02

申请人： The Regents of the University of California

发明人： Samir Mitragotri ,  Sumit Paliwal ,  Makoto Ogura

IPC分类号： A61B10/00 ,  A61B10/02 ,  C12M1/42 ,  C12M1/00 ,  A61M37/00 ,  G01N1/28 ,  G01N1/40 ,  A61B18/04 ,  A61K31/522 ,  A61K38/28 ,  A61N7/00 ,  A61B10/04 ,  A61B18/20 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61N7/02 ,  G01N1/44

CPC分类号： A61B10/02 ,  A61B10/0045 ,  A61B10/0096 ,  A61B10/0283 ,  A61B10/04 ,  A61B18/04 ,  A61B18/20 ,  A61B2010/0208 ,  A61B2017/00761 ,  A61B2017/320004 ,  A61B2018/00452 ,  A61K31/522 ,  A61K38/28 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61N7/00 ,  A61N7/02 ,  A61N2007/0034 ,  C12M23/28 ,  C12M31/00 ,  C12M35/08 ,  G01N1/286 ,  G01N1/4044 ,  G01N1/44 ,  Y10T436/2575

摘要： Disclosed are kits for at least partly liquefying tissue. The kit may include a liquefaction promoting medium (LPM). The LPM may include a non-ionic surfactant; a zwitterionic surfactant; and an abrasive material. The kit may include instructions. The instructions may direct a user to treat a tissue of a living subject by: applying the LPM together with the abrasive material to the tissue of the living subject; and transmitting energy to the tissue of the living subject through the abrasive material in the presence of the LPM effective to cause at least partial dissolution of one or more components of the tissue of the living subject.