-
公开(公告)号：US20070009427A1
公开(公告)日：2007-01-11
申请号：US11175595
申请日：2005-07-06
申请人： Faisal Syud , Nichole Wood , Andrew Torres , Mark Baillie , Dinko Eduardo Trotter , Cristina Hehir , Ming Zhao , Daniel Kramer
发明人： Faisal Syud , Nichole Wood , Andrew Torres , Mark Baillie , Dinko Eduardo Trotter , Cristina Hehir , Ming Zhao , Daniel Kramer
IPC分类号： A61K51/00
CPC分类号： B82Y5/00 , A61K47/6899 , A61K51/04
摘要： A set of compounds that includes an active-agent labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a ligand coupled to an active agent. The pretargeting conjugate includes a protein conjugated to a targeting species having a targeting moiety capable of binding to an in-vivo target or a biomarker produced by or associated with the target. The protein and the ligand are covalently attached. Also disclosed are methods of administering the pretargeting species and the active-agent labeled species to a subject for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.
摘要翻译： 公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。 活性剂标记的物质包括与活性剂偶联的配体。 预靶向缀合物包括与靶向物质缀合的蛋白质，其具有能够结合体内靶标的靶向部分或由靶产生或与靶标相关的生物标志物。 蛋白质和配体共价连接。 还公开了将预靶向物种和活性剂标记物种施用于受试者以诊断或治疗疾病状况或评估治疗疾病状况的有效性的方法。
-
公开(公告)号：US20070009428A1
公开(公告)日：2007-01-11
申请号：US11175668
申请日：2005-07-06
申请人： Faisal Syud , Nichole Wood , Andrew Torres , Mark Baillie , Dinko Trotter , Cristina Hehir , Ming Zhao , Daniel Kramer
发明人： Faisal Syud , Nichole Wood , Andrew Torres , Mark Baillie , Dinko Trotter , Cristina Hehir , Ming Zhao , Daniel Kramer
IPC分类号： A61K51/00
CPC分类号： A61K51/04 , A61K47/6899 , B82Y5/00
摘要： A set of compounds that includes an active-agent labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a ligand coupled to an active agent. The pretargeting conjugate includes a protein conjugated to a targeting species having a targeting moiety capable of binding to an in-vivo target or a biomarker produced by or associated with the target. The protein is substantially free of a cofactor. Also disclosed are methods of administering the pretargeting species and the active-agent labeled species to a subject for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.
摘要翻译： 公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。 活性剂标记的物质包括与活性剂偶联的配体。 预靶向缀合物包括与靶向物质缀合的蛋白质，其具有能够结合体内靶标的靶向部分或由靶产生或与靶标相关的生物标志物。 蛋白质基本上不含辅因子。 还公开了将预靶向物种和活性剂标记物种施用于受试者以诊断或治疗疾病状况或评估治疗疾病状况的有效性的方法。
-
公开(公告)号：US20070009435A1
公开(公告)日：2007-01-11
申请号：US11175596
申请日：2005-07-06
申请人： Faisal Syud , Nichole Wood , Daniel Kramer , Mark Baillie , Dinko Eduardo Trotter , Anup Sood , Ming Zhao
发明人： Faisal Syud , Nichole Wood , Daniel Kramer , Mark Baillie , Dinko Eduardo Trotter , Anup Sood , Ming Zhao
IPC分类号： A61K51/00 , A61K48/00 , C07H21/02 , C07F9/6533
CPC分类号： C07F9/65586 , A61K49/0002 , A61K51/0491 , A61K51/0495 , C07F9/65616
摘要： A set of compounds that includes an active agent-labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a first oligomeric nucleotide or mimic thereof conjugated to a linker having a first moiety coupled with a diagnostic active agent. The pretargeting conjugate includes a second oligomeric nucleotide or mimic thereof conjugated to a targeting species having a targeting moiety capable of binding to a target or a marker produced by or associated with the target. The second oligomeric nucleotide or mimic thereof has a sequence that is at least partially complementary to a sequence of the first oligomeric nucleotide or mimic thereof. Also disclosed are methods of administering the pretargeting conjugate and active agent-labeled species to a subject for diagnosing a disease condition or assessing the effectiveness of a treatment of the disease condition.
摘要翻译： 公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。 活性剂标记的物质包括与具有与诊断活性剂偶联的第一部分的接头缀合的第一寡聚核苷酸或其模拟物。 预靶向缀合物包括与靶向物质缀合的第二寡聚核苷酸或其模拟物，所述靶向物质具有能够结合靶标的靶向部分或由靶产生或与靶标相关的标记。 第二寡聚核苷酸或其模拟物具有与第一寡核苷酸序列至少部分互补的序列或其模拟物。 还公开了将预靶向缀合物和活性剂标记物质施用于受试者以诊断疾病状况或评估治疗疾病状况的有效性的方法。
-
公开(公告)号：US20050260131A1
公开(公告)日：2005-11-24
申请号：US10851359
申请日：2004-05-20
申请人： Mohan Amaratunga , Bahram Moasser , Faisal Syud , John Brogan , Daniel Kramer
发明人： Mohan Amaratunga , Bahram Moasser , Faisal Syud , John Brogan , Daniel Kramer
CPC分类号： C07H21/00
摘要： Pharmaceuticals for enhanced delivery to a disease target comprises a pair of compounds. The first compound comprises a first oligopeptide conjugated to a first moiety for coupling with a diagnostic or therapeutic active agent. The second compound comprises a second oligopeptide conjugated to a targeting species having a targeting moiety capable of binding to a target. The second oligopeptide has a sequence that is complementary to a sequence of the first oligopeptide. The first and second oligopeptides can be complementary PNA sequences. The pharmaceuticals are administered into a subject in methods for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.
摘要翻译： 用于增强递送至疾病靶标的药物包含一对化合物。 第一化合物包含与第一部分缀合的第一寡肽，用于与诊断或治疗活性剂偶联。 第二化合物包含与具有能与靶标结合的靶向部分的靶向物质缀合的第二寡肽。 第二寡肽具有与第一寡肽的序列互补的序列。 第一和第二寡肽可以是互补的PNA序列。 药物在用于诊断或治疗疾病状况的方法或评估治疗疾病状况的有效性的方法中施用于受试者。
-
公开(公告)号：US20060058218A1
公开(公告)日：2006-03-16
申请号：US10937323
申请日：2004-09-10
申请人： Faisal Syud , John Brogan , Daniel Kramer
发明人： Faisal Syud , John Brogan , Daniel Kramer
CPC分类号： C07K1/13 , C07K1/1077
摘要： There is provided a technique for conjugating one or more complexing agents with a targeting moiety, such as natural amino acids, unnatural amino acids, peptides, peptide nucleic acids, nucleotides, and analogs and derivatives thereof. The one or more complexing agents are conjugated at one or more free amino groups of the targeting moiety while the moiety is attached to a solid substrate.
摘要翻译： 提供了一种用于将一种或多种络合剂与靶向部分（例如天然氨基酸，非天然氨基酸，肽，肽核酸，核苷酸及其类似物和衍生物）缀合的技术。 一种或多种络合剂在靶向部分的一个或多个游离氨基处缀合，而该部分连接到固体基质上。
-
6.发明授权Refrigerating systems with multiple evaporator fan and step control therefor 失效具有多个蒸发器风扇的制冷系统及其步进控制
公开(公告)号：US4137057A
公开(公告)日：1979-01-30
申请号：US765805
申请日：1977-02-04
申请人： Zenon Piet , Daniel Kramer
发明人： Zenon Piet , Daniel Kramer
CPC分类号： F25B49/02 , F25B2400/074 , F25B2600/0251 , F25B2600/112 , Y02B30/743
摘要： A refrigeration system for cooling air having an evaporator; a compressor; a control for establishing ON periods and OFF periods of the compressor; at least two motor-driven fans positioned to force air over the evaporator; and a control system for the evaporator fans to cause fewer of the fans to run during compressor OFF periods and more of the fans to run during compressor ON periods.
摘要翻译： 一种用于冷却具有蒸发器的空气的制冷系统; 压缩机 用于建立压缩机的接通时段和关闭周期的控制; 至少两个电动机风扇定位成迫使空气在蒸发器上方; 以及用于蒸发器风扇的控制系统，使得在压缩机关闭期间运行较少的风扇并且在压缩机接通期间更多的风扇运行。
-
公开(公告)号：US4102151A
公开(公告)日：1978-07-25
申请号：US790289
申请日：1977-04-25
申请人： Daniel Kramer , Israel Kramer , Harold Kramer , Lawrence Board , Ram Chopra , William Micai
发明人： Daniel Kramer , Israel Kramer , Harold Kramer , Lawrence Board , Ram Chopra , William Micai
CPC分类号： F25B31/004 , F25B41/04 , F25B47/022
摘要： A compression type refrigeration system including at least one frosting evaporator positioned to refrigerate air. The evaporator has a liquid refrigerant inlet to which is connected an expansion valve. The evaporator also has a hot gas inlet; a liquid line supplies liquid to the expansion valve; a branch in the liquid line controlled by a solenoid valve connects to the hot gas inlet. The condensing unit, which includes compressor, condenser, receiver and re-evaporator, are valve-controlled so that during refrigeration, discharge gas from the compressor flows through the condenser, receiver, liquid line and expansion valve seriatim, but during defrost, gas from the compressor bypasses the condenser and flows instead from the compressor through the receiver, liquid line and hot gas inlet of the evaporator seriatim.
-
公开(公告)号：US20160225054A1
公开(公告)日：2016-08-04
申请号：US15091727
申请日：2016-04-06
申请人： Brian Scott Johnson , Brian M. Johnson , Badrul M. Sarwar , Benny Soetarman , Rajyashree Mukherjee , Venkat Sundaranatha , Neelakantan Sundaresan , Randall Scott Shoup , Daniel Kramer , Jason M. Heidema , Musaab At-Taras , Alvaro Bolivar , Jean-David Ruvini
发明人： Brian Scott Johnson , Brian M. Johnson , Badrul M. Sarwar , Benny Soetarman , Rajyashree Mukherjee , Venkat Sundaranatha , Neelakantan Sundaresan , Randall Scott Shoup , Daniel Kramer , Jason M. Heidema , Musaab At-Taras , Alvaro Bolivar , Jean-David Ruvini
CPC分类号： G06Q30/0623 , G06F17/30525 , G06F17/30867 , G06Q30/02 , G06Q30/0603 , G06Q30/0621 , G06Q30/0631
摘要： A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.
-
公开(公告)号：US4068493A
公开(公告)日：1978-01-17
申请号：US663867
申请日：1976-03-04
申请人： William Micai , Daniel Kramer
发明人： William Micai , Daniel Kramer
IPC分类号： F25B43/00
CPC分类号： F25B43/006 , Y10T137/3006
摘要： A suction accumulator for refrigeration systems having a tank with an inlet fitting for conveying it to refrigerant vapor from the evaporator which is mixed with oil and at times with liquid refrigerant. The tank has an outlet fitting for conveying away the refrigerant vapor from which the oil and liquid refrigerant have been separated. An oil return conduit is located underneath the tank. One end of the oil return conduit is connected into the bottom of the tank; the other end to the outlet fitting of the accumulator. Located within this oil return conduit is a thermostatic expansion valve whose bulb is located on the oil return conduit between the tank and the expansion valve. This bulb senses low superheat when liquid refrigerant is in the tank and in the conduit, and causes the expansion valve to close when liquid refrigerant is present, preventing the flow of large amounts of the liquid refrigerant into the outlet conduit. When no liquid refrigerant, but only oil, is present, the bulb senses superheat and causes the expansion valve to open, allowing relatively free flow of the oil from the accumulator tank into the outlet conduit. Another discriminating device is a float whose specific gravity is such that it floats in liquid halocarbon but sinks in oil.
摘要翻译： 一种用于制冷系统的抽吸蓄能器，具有一个具有入口配件的罐，用于将其从蒸发器输送到制冷剂蒸汽，该蒸发器与油混合并且有时与液体制冷剂混合。 罐具有用于输送已经分离出油和液体制冷剂的制冷剂蒸汽的出口配件。 回油管位于罐体下方。 回油管的一端连接到罐的底部; 另一端到蓄能器的出口接头。 位于该回油管道内的是恒温膨胀阀，其灯泡位于罐和膨胀阀之间的回油管道上。 当液体制冷剂在罐中和管道中时，该灯泡感测到低过热，并且当存在液体制冷剂时导致膨胀阀关闭，从而防止大量液体制冷剂流入出口导管。 当没有液体制冷剂但仅存在油时，灯泡感测到过热并使膨胀阀打开，允许油从蓄液箱相对自由流入出口管道。 另一个鉴别装置是一种浮子，其比重使其漂浮在液体卤化碳中但沉入油中。
-
公开(公告)号：US20070192227A1
公开(公告)日：2007-08-16
申请号：US11540501
申请日：2006-09-29
IPC分类号： G06Q40/00
摘要： In the financial-services industry, there are online centers that help brokers to match sellers and buyers of stock based on indications of interest (IOIs). However, at least some of these centers are not only limited in the types of IOIs that they provide, but also in the ways how they allow IOI senders to control IOI usage. Accordingly, the present inventors devised, among other things, exemplary systems, methods, interfaces, and software that enhance the ability of such online centers, or financial-information systems, to facilitate trades. One exemplary system provides an IOI which is associated with an online negotiation capability. Some embodiments provide mechanisms for users, such as broker-dealers, to define different IOI response privileges for recipients of their IOIs. To reduce the market risks of failed negotiations, some embodiments provide automated features for comparing confidential information from traders and initiating online negotiations for stock transactions contingent on favorable comparisons.
摘要翻译： 在金融服务行业，有一些在线中心帮助经纪人根据利益指标（IOI）来匹配卖方和买方的股票。 但是，这些中心中至少有一些不仅仅限于它们提供的IOI类型，而且还限制了IOI发送方如何控制IOI的使用。 因此，本发明人尤其设计了增强这种在线中心或金融信息系统以促进交易的能力的示例性系统，方法，界面和软件。 一个示例性系统提供与在线协商能力相关联的IOI。 一些实施例为用户（例如经纪人 - 经销商）提供为其IOI的接收者定义不同的IOI响应特权的机制。 为了降低失败谈判的市场风险，一些实施例提供用于比较交易者的机密信息的自动化功能，并且根据有利的比较启动股票交易的在线谈判。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.031 秒)
