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    Compounds and methods for enhanced delivery to disease targets
    3.
    发明申请
    Compounds and methods for enhanced delivery to disease targets 审中-公开
    用于增强输送到疾病目标的化合物和方法

    公开(公告)号：US20070009428A1

    公开(公告)日：2007-01-11

    申请号：US11175668

    申请日：2005-07-06

    申请人： Faisal Syud ,  Nichole Wood ,  Andrew Torres ,  Mark Baillie ,  Dinko Trotter ,  Cristina Hehir ,  Ming Zhao ,  Daniel Kramer

    发明人： Faisal Syud ,  Nichole Wood ,  Andrew Torres ,  Mark Baillie ,  Dinko Trotter ,  Cristina Hehir ,  Ming Zhao ,  Daniel Kramer

    IPC分类号： A61K51/00

    CPC分类号： A61K51/04 ,  A61K47/6899 ,  B82Y5/00

    摘要： A set of compounds that includes an active-agent labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a ligand coupled to an active agent. The pretargeting conjugate includes a protein conjugated to a targeting species having a targeting moiety capable of binding to an in-vivo target or a biomarker produced by or associated with the target. The protein is substantially free of a cofactor. Also disclosed are methods of administering the pretargeting species and the active-agent labeled species to a subject for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.

    摘要翻译： 公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。 活性剂标记的物质包括与活性剂偶联的配体。 预靶向缀合物包括与靶向物质缀合的蛋白质，其具有能够结合体内靶标的靶向部分或由靶产生或与靶标相关的生物标志物。 蛋白质基本上不含辅因子。 还公开了将预靶向物种和活性剂标记物种施用于受试者以诊断或治疗疾病状况或评估治疗疾病状况的有效性的方法。

    System for managing employee performance in a complex environment
    4.
    发明申请
    System for managing employee performance in a complex environment 审中-公开
    用于在复杂环境中管理员工绩效的系统

    公开(公告)号：US20060203991A1

    公开(公告)日：2006-09-14

    申请号：US11200840

    申请日：2005-08-10

    申请人： Daniel Kramer ,  Patrick Beasley ,  David Nti-Berko

    发明人： Daniel Kramer ,  Patrick Beasley ,  David Nti-Berko

    IPC分类号： H04M3/00

    CPC分类号： H04M3/5175

    摘要： Employee performance in a call center or similar complex work environment is managed by selecting a controlled number of performance criteria from among numerous possible performance criteria, establishing performance goals for the selected performance criteria, communicating the goals to the call center employees, monitoring the actual performance of the employees in relation to the performance goals, and reporting the performance of the employees in relation to the performance goals to the employees, management or both.

    摘要翻译： 呼叫中心或类似复杂工作环境中的员工绩效是通过从众多可能的绩效标准中选择受控数量的绩效标准来管理的，为所选绩效标准确定绩效目标，将目标传达给呼叫中心员工，监控实际绩效 员工的绩效目标，并向雇员，管理层或两者报告与员工绩效有关的绩效目标。

    Active electrode, bio-impedance based, tissue discrimination system and methods of use
    5.
    发明申请
    Active electrode, bio-impedance based, tissue discrimination system and methods of use 失效
    活性电极，基于生物阻抗，组织鉴别系统和使用方法

    公开(公告)号：US20060085049A1

    公开(公告)日：2006-04-20

    申请号：US11252568

    申请日：2005-10-19

    申请人： Phillip Cory ,  Joan Cory ,  Waldean Schulz ,  Daniel Kramer ,  Paul Ray

    发明人： Phillip Cory ,  Joan Cory ,  Waldean Schulz ,  Daniel Kramer ,  Paul Ray

    IPC分类号： A61N1/08 ,  A61B5/05

    CPC分类号： A61B5/4893 ,  A61B5/0536 ,  A61B5/4041 ,  A61B5/4519 ,  A61B2562/0209 ,  A61B2562/046

    摘要： Systems and methods for discriminating and locating tissues within a body involve applying a waveform signal to tissue between two electrodes and measuring the electrical characteristics of the signal transmitted through the tissue. At least one of the electrodes is constrained in area so that localized electrical characteristics of the tissue are measured. Such localized electrical characteristics are determined over a portion of a body of the subject by using an array of electrodes or electrodes that can be moved over the body. A controller may implement the process and perform calculations on the measured data to identify tissue types and locations within the measured area, and to present results in graphical form. Results may be combined with other tissue imaging technologies and with image-guided systems.

    摘要翻译： 用于区分和定位身体内的组织的系统和方法包括将波形信号施加到两个电极之间的组织并测量透过组织的信号的电特性。 电极中的至少一个被限制在区域中，使得测量组织的局部电特性。 通过使用能够在身体上移动的电极阵列或电极来确定这种局部电特性，使其在身体的一部分上被确定。 控制器可以实施该过程并且对所测量的数据执行计算以识别测量区域内的组织类型和位置，并以图形形式呈现结果。 结果可能与其他组织成像技术和图像引导系统相结合。

    Tissue dissociation device
    8.
    发明申请
    Tissue dissociation device 有权
    组织解离装置

    公开(公告)号：US20070148756A1

    公开(公告)日：2007-06-28

    申请号：US10572495

    申请日：2004-09-21

    申请人： Lawrence Bullen ,  Herbert Bresler ,  Daniel Kramer

    发明人： Lawrence Bullen ,  Herbert Bresler ,  Daniel Kramer

    IPC分类号： C12N1/02 ,  B02B5/02

    CPC分类号： C12M45/02

    摘要： A tissue dissociation device (10) includes a container (12) having a sterile interior for holding the tissue to be dissociated and a liquid medium. The device (10) also includes a dissociation element (54), inside the container (12), for engaging the tissue to cause dissociation of the tissue. The device (10) also includes a resistive element (81), inside the container (12), for resisting movement of the tissue in response to the engagement by the dissociation element (54). Relative motion between and the resulting resistance provided by the resistive element (81) allows the dissociation element (54) to effectively dissociate the tissue. A powered tissue dissociation device includes a power source operatively connected to the dissociation element (54) for causing the dissociation element (54) to move into engagement with the tissue

    摘要翻译： 组织解离装置（10）包括具有用于保持要解离的组织的无菌内部的容器（12）和液体介质。 装置（10）还包括在容器（12）内部的解离元件（54），用于接合组织以引起组织的解离。 装置（10）还包括在容器（12）内部的电阻元件（81），用于响应于解离元件（54）的接合而抵抗组织的移动。 由电阻元件（81）提供的相对运动和由此产生的电阻允许解离元件（54）有效地解离组织。 动力组织解离装置包括可操作地连接到解离元件（54）的电源，用于使解离元件（54）移动成与组织接合

    Pharmaceuticals for enhanced delivery to disease targets
    10.
    发明申请
    Pharmaceuticals for enhanced delivery to disease targets 审中-公开
    用于增强输送到疾病目标的药物

    公开(公告)号：US20050260131A1

    公开(公告)日：2005-11-24

    申请号：US10851359

    申请日：2004-05-20

    申请人： Mohan Amaratunga ,  Bahram Moasser ,  Faisal Syud ,  John Brogan ,  Daniel Kramer

    发明人： Mohan Amaratunga ,  Bahram Moasser ,  Faisal Syud ,  John Brogan ,  Daniel Kramer

    IPC分类号： C07H21/00 ,  C07K14/00 ,  A61K51/00 ,  A61K48/00 ,  A61K49/00 ,  C07K14/52 ,  C07K16/46

    CPC分类号： C07H21/00

    摘要： Pharmaceuticals for enhanced delivery to a disease target comprises a pair of compounds. The first compound comprises a first oligopeptide conjugated to a first moiety for coupling with a diagnostic or therapeutic active agent. The second compound comprises a second oligopeptide conjugated to a targeting species having a targeting moiety capable of binding to a target. The second oligopeptide has a sequence that is complementary to a sequence of the first oligopeptide. The first and second oligopeptides can be complementary PNA sequences. The pharmaceuticals are administered into a subject in methods for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.

    摘要翻译： 用于增强递送至疾病靶标的药物包含一对化合物。 第一化合物包含与第一部分缀合的第一寡肽，用于与诊断或治疗活性剂偶联。 第二化合物包含与具有能与靶标结合的靶向部分的靶向物质缀合的第二寡肽。 第二寡肽具有与第一寡肽的序列互补的序列。 第一和第二寡肽可以是互补的PNA序列。 药物在用于诊断或治疗疾病状况的方法或评估治疗疾病状况的有效性的方法中施用于受试者。